Reactome | MAP2K7(2-?) [cytosol]

MAP2K7(2-?) [cytosol]

Stable Identifier

R-HSA-5211389

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

MAP2K7 small LF fragment 1

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Locations in the PathwayBrowser for interactor UniProt:P45983 MAPK8

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Literature References

PubMed ID	Title	Journal	Year
11104681	Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor Mock, M, Napolitani, G, Montecucco, C, Bernardi, L, Vitale, G	Biochem. J.	2000

External Reference Information

External Reference

UniProt:O14733 MAP2K7

Gene Names

MAP2K7, JNKK2, MEK7, MKK7, PRKMK7, SKK4

Chain

initiator methionine:, chain:2-419

Reference Genes

COSMIC (genes):MAP2K7 MAP2K7

dbSNP Gene:5609 MAP2K7

ENSEMBL:ENSG00000076984 MAP2K7

Participates

as an output of

Anthrax lef cleaves target cell MAP2K7 (MEK7) (Homo sapiens)

Other forms of this molecule

MAP2K7(?-419) [cytosol]

MAP2K7 [cytosol]

p-S271,T275-MAP2K7 [cytosol]

Disease

Name	Identifier	Synonyms
anthrax disease	DOID:7427

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43318 MAP3K7	10	PolyUb-MAP3K7 [cytosol] (R-HSA-6782968) MAP3K7 [plasma membrane] (R-HSA-9012677) p-T187-MAP3K7 [cytosol] (R-HSA-206014) K63polyUb-34,158-TAK1 [cytosol] (R-HSA-5607643) K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol] (R-HSA-5607649) p-MAP3K7 [cytosol] (R-HSA-168163) MAP3K7 [endosome membrane] (R-HSA-450315) p-T184,T187-MAP3K7 [endosome membrane] (R-HSA-450332) MAP3K7 [cytosol] (R-HSA-168156) p-T184,T187-MAP3K7 [cytosol] (R-HSA-202527)	0.674	3
IntAct:EBI-9998887 (DTP3)-TYR,ARG,PHE			0.672	7
UniProt:O75293 GA45B			0.645	8
UniProt:Q9UQF2 JIP1			0.623	5
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.564	2
UniProt:P45983 MAPK8	3	MAPK8 [cytosol] (R-HSA-168141) p-T,Y-MAPK8 [cytosol] (R-HSA-194371) p-T,Y-MAPK8 [nucleoplasm] (R-HSA-216349)	0.483	4
UniProt:P27986 PIK3R1	16	PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) p-Y-PIK3R1 [cytosol] (R-HSA-9680647)	0.462	3

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