Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
MAP2K4(?-399) [cytosol]
Stable Identifier
R-HSA-5211396
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
MAP2K4 large LF fragment
Icon
Locations in the PathwayBrowser for interactor UniProt:P45983 MAPK8
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Bacterial Infection Pathways (Homo sapiens)
Uptake and actions of bacterial toxins (Homo sapiens)
Uptake and function of anthrax toxins (Homo sapiens)
Anthrax lef cleaves target cell MAP2K4 (MEK4) (Homo sapiens)
MAP2K4(?-399) [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
11104681
Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor
Mock, M
,
Napolitani, G
,
Montecucco, C
,
Bernardi, L
,
Vitale, G
Biochem. J.
2000
External Reference Information
External Reference
UniProt:P45985 MAP2K4
Gene Names
MAP2K4, JNKK1, MEK4, MKK4, PRKMK4, SEK1, SERK1, SKK1
Chain
initiator methionine:, chain:2-399
Reference Genes
BioGPS Gene:6416 MAP2K4
COSMIC (genes):MAP2K4 MAP2K4
CTD Gene:6416 MAP2K4
dbSNP Gene:6416 MAP2K4
ENSEMBL:ENSG00000065559 MAP2K4
HGNC:6844 MAP2K4
KEGG:hsa:6416 MAP2K4
Monarch:6416 MAP2K4
NCBI Gene:6416 MAP2K4
OMIM:601335 MAP2K4
UCSC:P45985 MAP2K4
Reference Transcript
RefSeq:NM_001281435.1 MAP2K4
RefSeq:NM_003010.3 MAP2K4
Other Identifiers
11732821_a_at
11732822_a_at
11732823_s_at
11732824_x_at
11754877_s_at
11756943_a_at
16831203
1712_s_at
1845_at
203265_PM_s_at
203265_s_at
203266_PM_s_at
203266_s_at
36910_at
3710682
3710683
3710691
3710695
3710699
3710706
3710711
3710713
3710714
3710715
3710716
3710717
3710723
3710724
3710725
3710726
3710732
3710734
3710735
3710736
3710737
4012521
4012553
4012554
4012556
4012560
4012561
6416
8005029
A_14_P202132
A_32_P6344
GE57743
GO:0000165
GO:0003824
GO:0004672
GO:0004674
GO:0004708
GO:0004713
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005829
GO:0006468
GO:0006915
GO:0007165
GO:0007254
GO:0008545
GO:0009611
GO:0012501
GO:0016740
GO:0030424
GO:0032839
GO:0034390
GO:0036481
GO:0038095
GO:0043065
GO:0043204
GO:0043226
GO:0043525
GO:0045740
GO:0046330
GO:0051770
GO:0060090
GO:0061049
GO:0071260
GO:0072709
GO:0090398
GO:0106310
GO:0140096
GO:2000672
HMNXSV003025465
Hs.75217.0.S2_3p_a_at
ILMN_2100689
ILMN_2100693
L36870_at
PH_hs_0029190
TC17000155.hg
TC17002052.hg
U17743_s_at
g4506888_3p_a_at
Participates
as an output of
Anthrax lef cleaves target cell MAP2K4 (MEK4) (Homo sapiens)
Other forms of this molecule
MAP2K4(1-?) [cytosol]
p-S257,T261-MAP2K4 [cytosol]
MAP2K4 [cytosol]
Disease
Name
Identifier
Synonyms
anthrax disease
DOID:7427
Cross References
RefSeq
NP_003001.1
,
NP_001268364.1
ZINC - World Drugs
MP2K4_HUMAN
Guide to Pharmacology - Targets
2065
ENSEMBL
ENSP00000410402
,
ENSP00000262445
,
ENST00000415385
,
ENST00000353533
OpenTargets
ENSG00000065559
ZINC - FDA approved
MP2K4_HUMAN
ZINC - Substances
MP2K4_HUMAN
ZINC - Biogenic
MP2K4_HUMAN
ZINC target
P45985
PRO
P45985
GlyGen
P45985
PDB
3VUT
,
3ALO
,
3ALN
ZINC - Investigational
MP2K4_HUMAN
IntEnz
2.7.12.2
HPA
ENSG00000065559-MAP2K4
Pharos - Targets
P45985
ZINC - Predictions - Purchasable
MP2K4_HUMAN
HMDB Protein
HMDBP01366
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P45983 MAPK8
3
MAPK8 [cytosol]
(R-HSA-168141)
p-T,Y-MAPK8 [cytosol]
(R-HSA-194371)
p-T,Y-MAPK8 [nucleoplasm]
(R-HSA-216349)
0.688
3
UniProt:Q13233 MAP3K1
2
MAP3K1 [cytosol]
(R-HSA-166866)
p-T1400,T1412-MAP3K1 [cytosol]
(R-HSA-2685607)
0.602
3
UniProt:P45984 MAPK9
3
MAPK9 [cytosol]
(R-HSA-450355)
p-T183,Y185-MAPK9 [cytosol]
(R-HSA-450293)
p-T183,Y185-MAPK9 [nucleoplasm]
(R-HSA-450319)
0.547
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text