Reactome | SHARPIN [cytosol]

SHARPIN [cytosol]

Stable Identifier

R-HSA-5212666

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Shank-associated RH domain-interacting protein, SIPL1, hSIPL1

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9H0F6 SHARPIN

Gene Names

SHARPIN, SIPL1, PSEC0216

Chain

chain:1-387

Reference Genes

COSMIC (genes):SHARPIN SHARPIN

ENSEMBL:ENSG00000179526 SHARPIN

HGNC:25321 SHARPIN

UCSC:Q9H0F6 SHARPIN

Other Identifiers

11724263_a_at

11744686_a_at

17082487

220973_PM_s_at

220973_s_at

3158115

3158116

3158117

3158118

3158119

3158120

3158121

3158122

3158123

3158124

3158125

3158126

3158128

3158129

3158130

3158131

3158132

3158134

3158135

3158136

3158137

3158138

3158139

3158140

3158141

3158142

3158143

3158144

3158145

3158146

44103_at

64307_s_at

72049_at

8153652

81858

A_23_P94942

A_24_P255798

A_33_P3213551

A_33_P3380567

GE83212

GO:0003824

GO:0004842

GO:0005515

GO:0005737

GO:0005829

GO:0007005

GO:0007249

GO:0008270

GO:0008544

GO:0010803

GO:0016567

GO:0016740

GO:0030163

GO:0030262

GO:0030674

GO:0031424

GO:0031593

GO:0042742

GO:0043123

GO:0043124

GO:0043130

GO:0043161

GO:0045202

GO:0046872

GO:0048856

GO:0050728

GO:0060090

GO:0071797

GO:0097039

GO:0098542

GO:0140096

GO:2000348

HMNXSV003012451

ILMN_1794780

PH_hs_0028139

PH_hs_0039581

TC08001742.hg

TC08002572.hg

g13569949_3p_s_at

Participates

as a component of

as an input of

SHARPIN binds SHANK proteins (Homo sapiens)

Inferred To

Ghost homologue of SHARPIN [cytosol] (Bos taurus)

Ghost homologue of SHARPIN [cytosol] (Canis familiaris)

Ghost homologue of SHARPIN [cytosol] (Gallus gallus)

Ghost homologue of SHARPIN [cytosol] (Mus musculus)

Ghost homologue of SHARPIN [cytosol] (Rattus norvegicus)

Ghost homologue of SHARPIN [cytosol] (Sus scrofa)

Cross References

ENSEMBL

ENST00000398712, ENSP00000381698, ENSG00000179526, ENSP00000352551, ENST00000359551

OpenTargets

ENSG00000179526

HPA

ENSG00000179526-SHARPIN

PRO

Q9H0F6

Pharos - Targets

Q9H0F6

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96EP0 RNF31	1	RNF31 [cytosol] (R-HSA-5212660)	0.958	36
UniProt:Q9BYM8 RBCK1	1	RBCK1 [cytosol] (R-HSA-976018)	0.905	29
UniProt:Q9Y6K9 IKBKG	12	IKBKG [cytosol] (R-HSA-168108) Ub-285-IKBKG [cytosol] (R-HSA-741397) K63polyUb-IKBKG [cytosol] (R-HSA-202530) IKBKG [nucleoplasm] (R-HSA-4755413) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG D406V [cytosol] (R-HSA-5262943)	0.818	14
UniProt:P01375 TNF	5	TNF(1-233) [plasma membrane] (R-HSA-66220) TNF(77-233) [extracellular region] (R-HSA-976821) TNF(1-76) [plasma membrane] (R-HSA-8863120) TNF(1-34) [plasma membrane] (R-HSA-8863367) TNF(52-76) [extracellular region] (R-HSA-8863375)	0.788	11
IntAct:EBI-4399559 UBIQ			0.737	6
UniProt:P17301 ITGA2	1	ITGA2 [plasma membrane] (R-HSA-57562)	0.664	5
UniProt:P08648 ITGA5	3	ITGA5(42-894) [plasma membrane] (R-HSA-202735) p-S-ITGA5 [plasma membrane] (R-HSA-9857662) ITGA5 [plasma membrane] (R-HSA-9857636)	0.602	4
UniProt:P21580 TNFAIP3	1	TNFAIP3 [cytosol] (R-HSA-688989)	0.597	3
UniProt:Q13490 BIRC2	5	BIRC2 [cytosol] (R-HSA-50847) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2(373-618) [cytosol] (R-HSA-202931) BIRC2(1-372) [cytosol] (R-HSA-202913) K63polyUb-BIRC2 [cytosol] (R-HSA-5668512)	0.564	7
UniProt:P07098 LIPF	1	LIPF [extracellular region] (R-HSA-6789323)	0.527	2
UniProt:P36941 LTBR	1	LTBR [plasma membrane] (R-HSA-5668750)	0.527	2
UniProt:Q9UJ41 RABGEF1	2	RABGEF1 [early endosome membrane] (R-HSA-2029032) RABGEF1 [cytosol] (R-HSA-8875419)	0.527	2
UniProt:Q15848 ADIPOQ	1	ADIPOQ [extracellular region] (R-HSA-1183052)	0.527	2

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