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p-S418-CYLD [cytosol]
Stable Identifier
R-HSA-5212667
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Probable ubiquitin carboxyl-terminal hydrolase CYLD, CYLD_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
TNF signaling (Homo sapiens)
Regulation of TNFR1 signaling (Homo sapiens)
CHUK, IKBKB phosphorylate CYLD at S418 (Homo sapiens)
p-S418-CYLD [cytosol] (Homo sapiens)
CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Homo sapiens)
p-S418-CYLD [cytosol] (Homo sapiens)
CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Homo sapiens)
p-S418-CYLD [cytosol] (Homo sapiens)
K63polyUb-RIPK1 is deubiquitinated (Homo sapiens)
p-S418-CYLD [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NQC7 CYLD
Gene Names
CYLD, CYLD1, KIAA0849, HSPC057
Chain
chain:1-956
Reference Genes
BioGPS Gene:1540 CYLD
COSMIC (genes):CYLD CYLD
CTD Gene:1540 CYLD
dbSNP Gene:1540 CYLD
ENSEMBL:ENSG00000083799 CYLD
ENSEMBL_homo_sapiens_GENE:ENSG00000083799.18 CYLD
HGNC:2584 CYLD
KEGG Gene (Homo sapiens):1540 CYLD
Monarch:1540 CYLD
NCBI Gene:1540 CYLD
OMIM:605018 CYLD
UCSC:Q9NQC7 CYLD
Reference Transcript
RefSeq:XM_017022979.1 CYLD
RefSeq:NM_001042412.1 CYLD
RefSeq:XM_005255812.2 CYLD
RefSeq:XM_011522907.2 CYLD
RefSeq:NM_001042355.1 CYLD
RefSeq:XM_017022978.1 CYLD
RefSeq:XM_017022980.1 CYLD
RefSeq:NM_015247.2 CYLD
RefSeq:XM_006721149.1 CYLD
RefSeq:XM_017022977.1 CYLD
Other Identifiers
11723093_a_at
11723094_a_at
11723095_a_at
11723096_a_at
1540
16818842
213295_3p_at
213295_PM_at
213295_at
214272_PM_at
214272_at
221903_PM_s_at
221903_s_at
221905_PM_at
221905_at
3660214
3660215
3660216
3660217
3660218
3660219
3660220
3660221
3660222
3660223
3660225
3660226
3660227
3660232
3660233
3660234
3660238
3660240
3660243
3660245
3660246
3660247
3660251
3660252
3660253
3660254
3660255
3660256
3660257
3660258
3660259
3660266
3660268
39582_PM_at
39582_at
7995552
A_14_P100177
A_23_P65996
A_24_P48078
A_33_P3251771
GE56265
GE81995
GO:0000278
GO:0002376
GO:0003824
GO:0004843
GO:0005515
GO:0005737
GO:0005813
GO:0005815
GO:0005819
GO:0005829
GO:0005856
GO:0005874
GO:0005881
GO:0005886
GO:0005929
GO:0006351
GO:0006355
GO:0006508
GO:0006954
GO:0007010
GO:0007049
GO:0007155
GO:0007346
GO:0008233
GO:0008234
GO:0008270
GO:0009898
GO:0010803
GO:0012501
GO:0016020
GO:0016055
GO:0016579
GO:0016787
GO:0019901
GO:0023052
GO:0030154
GO:0030496
GO:0032088
GO:0032480
GO:0036064
GO:0036211
GO:0042995
GO:0043226
GO:0043369
GO:0044782
GO:0045087
GO:0045577
GO:0045582
GO:0046329
GO:0046872
GO:0048471
GO:0048856
GO:0048872
GO:0050727
GO:0050728
GO:0050862
GO:0060544
GO:0061578
GO:0061815
GO:0065003
GO:0070064
GO:0070266
GO:0070423
GO:0070507
GO:0090090
GO:0097542
GO:0098542
GO:0140096
GO:1901026
GO:1901223
GO:1902017
GO:1903753
GO:1903829
GO:1990108
GO:1990380
GO:2000493
GO:2001238
GO:2001242
HMNXSV003001489
HMNXSV003036309
Hs.18827.0.S1_3p_s_at
Hs.18827.0.S2_3p_a_at
Hs.18827.0.S2_3p_x_at
Hs.18827.1.A1_3p_at
Hs.26295.0.S1_3p_at
Hs.26295.0.S1_3p_s_at
ILMN_1775508
ILMN_1896830
ILMN_2287941
PH_hs_0024407
TC16000443.hg
TC16001550.hg
p20022
Participates
as an output of
CHUK, IKBKB phosphorylate CYLD at S418 (Homo sapiens)
This entity regulates
Negatively
CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex
(Homo sapiens)
CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex
(Homo sapiens)
K63polyUb-RIPK1 is deubiquitinated
(Homo sapiens)
Other forms of this molecule
K48polyUb-K338, K530-CYLD [cytosol]
CYLD [cytosol]
Inferred To
phospho-RPS3A [cytosol]
(Plasmodium falciparum)
phospho-cyld [cytosol]
(Danio rerio)
phospho-rps102 [cytosol]
(Schizosaccharomyces pombe)
Homologues of p-S418-CYLD [cytosol]
(Saccharomyces cerevisiae)
Homologues of p-S418-CYLD [cytosol]
(Schizosaccharomyces pombe)
phospho-p-S418-CYLD [cytosol]
(Bos taurus)
phospho-p-S418-CYLD [cytosol]
(Gallus gallus)
phospho-p-S418-CYLD [cytosol]
(Mus musculus)
phospho-p-S418-CYLD [cytosol]
(Rattus norvegicus)
phospho-RPS1B [cytosol]
(Saccharomyces cerevisiae)
phospho-CYLD [cytosol]
(Canis familiaris)
phospho-CYLD [cytosol]
(Drosophila melanogaster)
phospho-CYLD [cytosol]
(Sus scrofa)
phospho-RPS1A [cytosol]
(Saccharomyces cerevisiae)
phospho-rps101 [cytosol]
(Schizosaccharomyces pombe)
phospho-rps3a [cytosol]
(Dictyostelium discoideum)
phospho-cyld-1 [cytosol]
(Caenorhabditis elegans)
Modified Residues
Name
O-phospho-L-serine at 418
Coordinate
418
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001035814.1
,
XP_016878467.1
,
XP_016878468.1
,
NP_056062.1
,
XP_016878466.1
,
XP_016878469.1
,
XP_006721212.1
,
XP_005255869.1
,
NP_001035877.1
,
XP_011521209.1
OpenTargets
ENSG00000083799
HPA
ENSG00000083799-CYLD
GeneCards
Q9NQC7
Ensembl
ENSP00000392025
,
ENST00000311559
,
ENST00000564326
,
ENST00000569418
,
ENST00000427738
,
ENST00000398568
,
ENSP00000457576
,
ENSP00000454515
,
ENSP00000308928
,
ENSG00000083799
,
ENSP00000381574
PRO
Q9NQC7
Pharos - Targets
Q9NQC7
Orphanet
15832
HMDB Protein
HMDBP02433
PDB
1IXD
,
1WHL
,
7OWC
,
7OWD
,
1WHM
,
2VHF
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.745
5
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.643
3
UniProt:Q71U36 TUBA1A
9
AcK-TUBA1A [cytosol]
(R-HSA-5618312)
Ac K40 TUBA1A [axonemal microtubule]
(R-HSA-5624852)
TUBA1A folding intermediate [cytosol]
(R-HSA-392805)
TUBA1A unfolded [cytosol]
(R-HSA-392767)
L-isoglutamyl polyglycyl-TUBA1A [cytosol]
(R-HSA-8867428)
Polyglutamyl-TUBA1A [cytosol]
(R-HSA-8867408)
TUBA1A(1-450) [cytosol]
(R-HSA-8955577)
TUBA1A [cytosol]
(R-HSA-191689)
TUBA1A [axonemal microtubule]
(R-HSA-5610433)
0.576
6
UniProt:Q9UBN7 HDAC6
4
HDAC6 [nucleoplasm]
(R-HSA-351589)
HDAC6 [late endosome lumen]
(R-HSA-9659980)
HDAC6 [cytosol]
(R-HSA-5324660)
HDAC6 [lysosomal lumen]
(R-HSA-9660002)
0.576
4
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.569
3
UniProt:Q9UM82 SPATA2
1
SPATA2 [cytosol]
(R-HSA-9796351)
0.564
3
UniProt:Q9Y6K9 IKBKG
12
IKBKG D406V [cytosol]
(R-HSA-5262943)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG *420Wext*447 [cytosol]
(R-HSA-5262978)
monoSUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG [nucleoplasm]
(R-HSA-4755413)
K63polyUb-IKBKG [cytosol]
(R-HSA-202530)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
IKBKG [cytosol]
(R-HSA-168108)
0.547
2
UniProt:Q96PV0 SYNGAP1
1
SYNGAP1 [cytosol]
(R-HSA-5658217)
0.527
5
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.527
2
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.527
2
UniProt:O95786 RIGI
4
PolyUb-DDX58 [cytosol]
(R-HSA-6782770)
K48polyUb-DDX58 [cytosol]
(R-HSA-3080568)
K63polyUb-DDX58 [cytosol]
(R-HSA-918191)
DDX58 [cytosol]
(R-HSA-168917)
0.524
2
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