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p-Y389,400-RUFY1 [early endosome membrane]
Stable Identifier
R-HSA-5215951
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
early endosome membrane
Synonyms
RUN and FYVE domain-containing protein 1, RUFY1_HUMAN
Locations in the PathwayBrowser for interactor UniProt:O75928 PIAS2
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Phospholipid metabolism (Homo sapiens)
PI Metabolism (Homo sapiens)
Synthesis of PIPs at the plasma membrane (Homo sapiens)
p-Y389,400-RUFY1 binds PI3P (Homo sapiens)
p-Y389,400-RUFY1 [early endosome membrane] (Homo sapiens)
p-Y389,400-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP (Homo sapiens)
p-Y389,400-RUFY1 [early endosome membrane] (Homo sapiens)
p-Y389,400-RUFY1 translocates from cytosol to early endosome membrane (Homo sapiens)
p-Y389,400-RUFY1 [early endosome membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96T51 RUFY1
Gene Names
RUFY1, RABIP4, ZFYVE12
Chain
chain:1-708
Reference Genes
BioGPS Gene:80230 RUFY1
COSMIC (genes):RUFY1 RUFY1
CTD Gene:80230 RUFY1
dbSNP Gene:80230 RUFY1
ENSEMBL:ENSG00000176783 RUFY1
HGNC:19760 RUFY1
Monarch:80230 RUFY1
NCBI Gene:80230 RUFY1
OMIM:610327 RUFY1
UCSC:Q96T51 RUFY1
Reference Transcript
RefSeq:NM_001040451.2 RUFY1
RefSeq:NM_001040452.2 RUFY1
RefSeq:XM_017009895.1 RUFY1
RefSeq:NM_025158.4 RUFY1
Other Identifiers
11720698_a_at
11740024_a_at
16993349
218243_PM_at
218243_at
233380_PM_s_at
233380_s_at
233381_PM_at
233381_at
2844083
2844084
2844086
2844087
2844088
2844089
2844090
2844091
2844094
2844095
2844096
2844102
2844104
2844106
2844107
2844108
2844110
2844111
2844113
2844114
2844115
2844116
2844117
2844118
2844121
2844122
2844123
2844124
2844125
2844126
2844127
2844128
2844129
2844130
2844131
53155_at
69344_r_at
80230
8110499
A_14_P126748
A_23_P73457
A_33_P3253799
GE62241
GE83876
GO:0005515
GO:0005737
GO:0005768
GO:0005829
GO:0006897
GO:0007264
GO:0008289
GO:0015031
GO:0016020
GO:0016192
GO:0016607
GO:0017124
GO:0030100
GO:0030674
GO:0031410
GO:0031901
GO:0034058
GO:0034498
GO:0042169
GO:0042802
GO:0043226
GO:0043231
GO:0046872
GO:0060090
GO:0061024
HMNXSV003011004
HMNXSV003036726
Hs.306769.0.A1_3p_at
ILMN_2277025
ILMN_2310968
PH_hs_0023658
TC05001046.hg
g13376756_3p_at
Participates
as a component of
p-Y389,400-RUFY1:PI3P [early endosome membrane] (Homo sapiens)
p-Y389,400-RUFY1:p-Y389,400-RUFY1:RAB4A:GTP:RAB5:GTP:RAB14:GTP [early endosome membrane] (Homo sapiens)
as an input of
p-Y389,400-RUFY1 binds PI3P (Homo sapiens)
p-Y389,400-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP (Homo sapiens)
as an output of
p-Y389,400-RUFY1 translocates from cytosol to early endosome membrane (Homo sapiens)
Other forms of this molecule
p-Y389,400-RUFY1 [cytosol]
RUFY1 [cytosol]
Inferred To
phospho-rufy1 [early endosome membrane]
(Xenopus tropicalis)
phospho-p-Y389,400-RUFY1 [early endosome membrane]
(Gallus gallus)
phospho-p-Y389,400-RUFY1 [early endosome membrane]
(Mus musculus)
phospho-RUFY1 [early endosome membrane]
(Bos taurus)
phospho-RUFY1 [early endosome membrane]
(Canis familiaris)
phospho-RUFY1 [early endosome membrane]
(Sus scrofa)
phospho-CG14261 [early endosome membrane]
(Drosophila melanogaster)
phospho-Rufy1 [early endosome membrane]
(Rattus norvegicus)
Modified Residues
Name
O4'-phospho-L-tyrosine at 389
Coordinate
389
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 400
Coordinate
400
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
ENSEMBL
ENST00000639909
,
ENST00000437570
,
ENST00000639102
,
ENST00000319449
,
ENST00000393438
,
ENSP00000377087
,
ENSP00000491803
,
ENSP00000492748
,
ENST00000639436
,
ENSP00000491925
,
ENSP00000390025
,
ENSP00000325594
OpenTargets
ENSG00000176783
HPA
ENSG00000176783-RUFY1
PRO
Q96T51
Pharos - Targets
Q96T51
GlyGen
Q96T51
HMDB Protein
HMDBP08571
PDB
2YQM
,
2YW8
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q68CQ4 UTP25
1
DIEXF [nucleoplasm]
(R-HSA-6790689)
0.742
5
UniProt:Q96DA2 RAB39B
3
GGC-RAB39B [Golgi membrane]
(R-HSA-8877796)
GGC-RAB39B [cytosol]
(R-HSA-8874006)
RAB39B [cytosol]
(R-HSA-8873679)
0.666
4
UniProt:O75928 PIAS2
1
PIAS2 [nucleoplasm]
(R-HSA-2993787)
0.581
3
UniProt:Q96QF0 RAB3IP
1
RAB3IP [cytosol]
(R-HSA-5617610)
0.556
3
UniProt:Q9BRA2 TXD17
0.556
3
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