Reactome | COG3 [Golgi membrane]

COG3 [Golgi membrane]

Stable Identifier

R-HSA-5216030

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi membrane

Synonyms

Conserved oligomeric Golgi complex subunit 3, COG3_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPI-mediated anterograde transport (Homo sapiens)
        
        COPI vesicle uncoating (Homo sapiens)
        
        COG complex [Golgi membrane] (Homo sapiens)
        
        COG3 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        COG complex [Golgi membrane] (Homo sapiens)
        
        COG3 [Golgi membrane] (Homo sapiens)
        
        Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
        
        COG complex [Golgi membrane] (Homo sapiens)
        
        COG3 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        COG complex [Golgi membrane] (Homo sapiens)
        
        COG3 [Golgi membrane] (Homo sapiens)
        
        cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        COG complex [Golgi membrane] (Homo sapiens)
        
        COG3 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        COG complex [Golgi membrane] (Homo sapiens)
        
        COG3 [Golgi membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96JB2 COG3

Gene Names

COG3, SEC34

Chain

initiator methionine:, chain:2-828

Reference Genes

BioGPS Gene:83548 COG3

COSMIC (genes):COG3 COG3

CTD Gene:83548 COG3

dbSNP Gene:83548 COG3

ENSEMBL:ENSG00000136152 COG3

HGNC:18619 COG3

KEGG:hsa:83548 COG3

Monarch:83548 COG3

NCBI Gene:83548 COG3

OMIM:606975 COG3

UCSC:Q96JB2 COG3

Reference Transcript

RefSeq:NM_031431.3 COG3

Other Identifiers

11745418_a_at

11748993_a_at

11749384_a_at

11755159_a_at

1554339_PM_a_at

1554339_a_at

16774551

223450_PM_s_at

223450_s_at

238228_PM_at

238228_at

3488254

3488255

3488256

3488257

3488258

3488259

3488260

3488261

3488262

3488263

3488265

3488266

3488267

3488268

3488269

3488270

3488271

3488273

3488274

3488275

3488277

3488278

3488279

3488281

3488282

3488285

3488287

3488290

3488292

3488293

3488294

3488295

3488301

3488303

3488305

3488307

3488309

3488310

3488311

3488315

3488316

3488317

3488318

75479_at

7968931

83548

86759_at

91712_at

A_14_P119032

A_14_P123918

A_24_P296070

A_24_P42613

GE54879

GE85226

GO:0000139

GO:0000301

GO:0005515

GO:0005794

GO:0005801

GO:0005829

GO:0005886

GO:0006486

GO:0006886

GO:0006888

GO:0006890

GO:0006891

GO:0007030

GO:0015031

GO:0016020

GO:0016192

GO:0017119

GO:0032580

GO:0032588

GO:0033365

GO:0043226

GO:0050821

GO:0070085

HMNXSV003030107

HMNXSV003034694

Hs.105414.0.A1_3p_at

Hs2.13392.2.A1_3p_s_at

ILMN_1776154

ILMN_2129715

PH_hs_0022268

TC13000176.hg

g12744920_3p_a_at

Participates

as a component of

COG complex [Golgi membrane] (Homo sapiens)

Other forms of this molecule

COG3 [trans-Golgi network membrane]

Inferred To

cogc-3 [Golgi membrane] (Caenorhabditis elegans)

Cog3 [Golgi membrane] (Drosophila melanogaster)

Cog3 [Golgi membrane] (Mus musculus)

Cog3 [Golgi membrane] (Rattus norvegicus)

cog3 [Golgi membrane] (Dictyostelium discoideum)

cog3 [Golgi membrane] (Schizosaccharomyces pombe)

COG3 [Golgi membrane] (Bos taurus)

COG3 [Golgi membrane] (Canis familiaris)

COG3 [Golgi membrane] (Gallus gallus)

COG3 [Golgi membrane] (Sus scrofa)

Ghost homologue of COG3 [Golgi membrane] (Xenopus tropicalis)

Cross References

ENSEMBL

ENSP00000258654, ENST00000349995, ENST00000617493, ENSP00000481332

OpenTargets

ENSG00000136152

HPA

ENSG00000136152-COG3

PRO

Q96JB2

Pharos - Targets

Q96JB2

GlyGen

Q96JB2

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC7 7a	5	7a [endolysosome membrane] (R-COV-9755945) 7a [endoplasmic reticulum membrane] (R-COV-9727308) 7a [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694750) 7a [endocytic vesicle membrane] (R-COV-9694645) 7a [virion membrane] (R-COV-9694648)	0.547	2
UniProt:Q15814 TBCC	1	TBCC [cytosol] (R-HSA-379537)	0.527	2
UniProt:Q9NZQ7 CD274	1	CD274 [plasma membrane] (R-HSA-3211776)	0.527	2
UniProt:Q8WVM8 SCFD1	1	SCFD1 [cytosol] (R-HSA-5688147)	0.462	2

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