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MRS2 [mitochondrial inner membrane]
Stable Identifier
R-HSA-5216072
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
Synonyms
Magnesium transporter MRS2 homolog, mitochondrial, MRS2_HUMAN
Locations in the PathwayBrowser for interactor UniProt:P08247 SYP
Expand all
Transport of small molecules (Homo sapiens)
Miscellaneous transport and binding events (Homo sapiens)
MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Homo sapiens)
MRS2 [mitochondrial inner membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9HD23 MRS2
Gene Names
MRS2, HPT, MRS2L
Chain
transit peptide:1-49, chain:50-443
Reference Genes
BioGPS Gene:57380 MRS2
COSMIC (genes):MRS2 MRS2
CTD Gene:57380 MRS2
dbSNP Gene:57380 MRS2
ENSEMBL:ENSG00000124532 MRS2
ENSEMBL_homo_sapiens_GENE:ENSG00000124532.15 MRS2
HGNC:13785 MRS2
KEGG Gene (Homo sapiens):57380 MRS2
Monarch:57380 MRS2
NCBI Gene:57380 MRS2
OMIM:619307 MRS2
UCSC:Q9HD23 MRS2
Reference Transcript
RefSeq:NM_001286264.1 MRS2
RefSeq:NM_020662.3 MRS2
RefSeq:NM_001286265.1 MRS2
RefSeq:NM_001286266.1 MRS2
Other Identifiers
11725681_s_at
11725682_x_at
11725683_at
11745838_a_at
11752747_a_at
11752748_x_at
11759577_at
17005348
218536_PM_at
218536_at
218538_PM_s_at
218538_s_at
228542_PM_at
228542_at
2898453
2898454
2898455
2898456
2898459
2898462
2898463
2898464
2898465
2898470
2898471
2898472
2898473
2898474
2898479
2898480
2898481
2898482
2898483
2898484
2898485
2898486
2898487
2898488
2898490
2898492
34687_at
57056_s_at
57380
76369_at
76371_g_at
8117194
92044_at
92045_g_at
A_14_P111162
A_23_P111373
A_33_P3255814
A_33_P3372281
GE54473
GE80457
GO:0005215
GO:0005515
GO:0005739
GO:0005743
GO:0006089
GO:0006811
GO:0015095
GO:0016020
GO:0043226
GO:0045016
GO:0055085
HMNXSV003021031
HMNXSV003053298
Hs.30057.0.S2_3p_at
Hs.30057.2.S1_3p_at
ILMN_1778677
PH_hs_0022611
TC06000144.hg
g10190701_3p_a_at
Inferred To
MRS2 [mitochondrial inner membrane]
(Bos taurus)
MRS2 [mitochondrial inner membrane]
(Canis familiaris)
MRS2 [mitochondrial inner membrane]
(Dictyostelium discoideum)
MRS2 [mitochondrial inner membrane]
(Gallus gallus)
MRS2 [mitochondrial inner membrane]
(Plasmodium falciparum)
MRS2 [mitochondrial inner membrane]
(Sus scrofa)
Mrs2 [mitochondrial inner membrane]
(Mus musculus)
Mrs2 [mitochondrial inner membrane]
(Rattus norvegicus)
mrs2 [mitochondrial inner membrane]
(Schizosaccharomyces pombe)
mrs2 [mitochondrial inner membrane]
(Xenopus tropicalis)
MFM1 [mitochondrial inner membrane]
(Saccharomyces cerevisiae)
Homologues of MRS2 [mitochondrial inner membrane]
(Plasmodium falciparum)
Cross References
RefSeq
NP_001273195.1
,
NP_001273193.1
,
NP_065713.1
,
NP_001273194.1
OpenTargets
ENSG00000124532
HPA
ENSG00000124532-MRS2
GeneCards
Q9HD23
Ensembl
ENSP00000399585
,
ENST00000378353
,
ENST00000378386
,
ENST00000443868
,
ENSG00000124532
,
ENSP00000367637
,
ENSP00000367604
PRO
Q9HD23
Pharos - Targets
Q9HD23
HMDB Protein
HMDBP08762
PDB
8TUP
,
8IP5
,
8IP3
,
8IP6
,
8TUL
,
8IP4
Interactors (22)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9H8X2 IPPK
2
IPPK [cytosol]
(R-HSA-1604598)
IPPK [nucleoplasm]
(R-HSA-2023949)
0.527
2
UniProt:Q9NWT8 AURKAIP1
1
AURKAIP1 [mitochondrial inner membrane]
(R-HSA-5368203)
0.527
2
UniProt:Q9P0J7 KCMF1
2
KCMF1 [extracellular region]
(R-HSA-6806467)
KCMF1 [ficolin-1-rich granule lumen]
(R-HSA-6801525)
0.527
2
UniProt:Q9H0U9 TSYL1
0.527
2
UniProt:Q92633 LPAR1
1
LPAR1 [plasma membrane]
(R-HSA-419354)
0.527
2
UniProt:Q8N5V2 NGEF
2
NGEF [cytosol]
(R-HSA-3006800)
p-Y179-NGEF [cytosol]
(R-HSA-3928441)
0.527
3
UniProt:Q96JJ6 JPH4
0.527
2
UniProt:Q99689 FEZ1
0.527
2
UniProt:Q9Y6E2 5MP1
0.527
3
UniProt:Q9BV97 ZNF747
1
ZNF747 [nucleoplasm]
(R-HSA-2586596)
0.527
3
UniProt:Q8TCT7 SPPL2B
1
SPPL2B [plasma membrane]
(R-HSA-8863116)
0.527
3
UniProt:Q9NZE8 MRPL35
1
MRPL35 [mitochondrial inner membrane]
(R-HSA-5368235)
0.527
2
UniProt:P28335 HTR2C
1
HTR2C [plasma membrane]
(R-HSA-390965)
0.527
2
UniProt:P08247 SYP
1
SYP [clathrin-sculpted glutamate transport vesicle membrane]
(R-HSA-5215991)
0.527
3
UniProt:Q6ZT07 TBCD9
0.527
2
UniProt:Q9H244 P2RY12
1
P2RY12 [plasma membrane]
(R-HSA-391959)
0.527
2
UniProt:Q5SY16 NOL9
1
NOL9 [nucleoplasm]
(R-HSA-6791216)
0.527
2
UniProt:O60443 GSDME
18
GSDME(1-270) G199E [cytosol]
(R-HSA-9710427)
GSDME(1-270) R48I [cytosol]
(R-HSA-9710474)
GSDME(1-270) I137T [cytosol]
(R-HSA-9710473)
GSDME W46* [cytosol]
(R-HSA-9711042)
GSDME(1-270) D18V [cytosol]
(R-HSA-9710466)
GSDME(1-270) D14Y [cytosol]
(R-HSA-9710450)
GSDME(1-270) P212L [cytosol]
(R-HSA-9710487)
GSDME(1-270) W44C [cytosol]
(R-HSA-9710470)
GSDME(1-270) I217N [cytosol]
(R-HSA-9710437)
GSDME E210* [cytosol]
(R-HSA-9710420)
GSDME(1-270) [cytosol]
(R-HSA-9647689)
GSDME [cytosol]
(R-HSA-9647620)
GSDME (271-496) [cytosol]
(R-HSA-9647615)
GSDME(1-270) E177V [cytosol]
(R-HSA-9710403)
GSDME(1-270) T196M [cytosol]
(R-HSA-9710429)
GSDME(1-270) G17D [cytosol]
(R-HSA-9710478)
GSDME(1-270) E134A [cytosol]
(R-HSA-9710410)
GSDME(1-270) N24D [cytosol]
(R-HSA-9710404)
0.527
2
UniProt:Q9H2A9 CHST8
1
CHST8 [Golgi membrane]
(R-HSA-6786024)
0.527
3
UniProt:P04004 VTN
1
VTN [extracellular region]
(R-HSA-215971)
0.527
2
UniProt:Q6ZMH5 SLC39A5
1
SLC39A5 [plasma membrane]
(R-HSA-442360)
0.527
2
UniProt:P04618 rev
3
REV (P04618) protein [extracellular region]
(R-HIV-174998)
REV (P04618) protein [nucleoplasm]
(R-HIV-175380)
REV (P04618) protein [cytosol]
(R-HIV-173267)
0.462
2
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