Reactome | COG2 [Golgi membrane]

COG2 [Golgi membrane]

Stable Identifier

R-HSA-5216080

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi membrane

Synonyms

Conserved oligomeric Golgi complex subunit 2, COG2_HUMAN

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPI-mediated anterograde transport (Homo sapiens)
        
        COPI vesicle uncoating (Homo sapiens)
        
        COG complex [Golgi membrane] (Homo sapiens)
        
        COG2 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        COG complex [Golgi membrane] (Homo sapiens)
        
        COG2 [Golgi membrane] (Homo sapiens)
        
        Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
        
        COG complex [Golgi membrane] (Homo sapiens)
        
        COG2 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        COG complex [Golgi membrane] (Homo sapiens)
        
        COG2 [Golgi membrane] (Homo sapiens)
        
        cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        COG complex [Golgi membrane] (Homo sapiens)
        
        COG2 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        COG complex [Golgi membrane] (Homo sapiens)
        
        COG2 [Golgi membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q14746 COG2

Gene Names

COG2, LDLC

Chain

chain:1-738

Reference Genes

BioGPS Gene:22796 COG2

COSMIC (genes):COG2 COG2

CTD Gene:22796 COG2

dbSNP Gene:22796 COG2

ENSEMBL:ENSG00000135775 COG2

HGNC:6546 COG2

KEGG:hsa:22796 COG2

Monarch:22796 COG2

NCBI Gene:22796 COG2

OMIM:606974 COG2

UCSC:Q14746 COG2

Reference Transcript

Other Identifiers

11743607_a_at

11747061_a_at

16678611

203073_PM_at

203073_at

22796

2384957

2384958

2384961

2384962

2384963

2384964

2384965

2384966

2384967

2384968

2384969

2384970

2384971

2384972

2384973

2384974

2384975

2384976

2384977

2384978

2384979

2384980

2384981

2384982

2384983

2384984

2384985

2384986

2384987

2384988

2384989

2384990

2384991

2384992

2384993

2384994

2384995

2384996

2384997

243608_PM_at

243608_at

38390_at

7910446

87574_at

A_14_P134639

A_23_P160809

A_23_P402437

A_24_P310946

GE60396

GE692590

GO:0000139

GO:0000301

GO:0005515

GO:0005794

GO:0005795

GO:0006891

GO:0007030

GO:0015031

GO:0016020

GO:0016192

GO:0017119

GO:0032588

GO:0043226

GO:0044877

GO:0070085

HMNXSV003047866

Hs.226925.0.A1_3p_at

ILMN_1776993

PH_hs_0004719

PH_hs_0037997

TC01001909.hg

Z34975_at

g6678675_3p_at

Participates

as a component of

COG complex [Golgi membrane] (Homo sapiens)

Other forms of this molecule

COG2 [trans-Golgi network membrane]

Inferred To

COG2 [Golgi membrane] (Bos taurus)

COG2 [Golgi membrane] (Canis familiaris)

COG2 [Golgi membrane] (Gallus gallus)

COG2 [Golgi membrane] (Sus scrofa)

Cog2 [Golgi membrane] (Drosophila melanogaster)

Cog2 [Golgi membrane] (Mus musculus)

Cog2 [Golgi membrane] (Rattus norvegicus)

Ghost homologue of COG2 [Golgi membrane] (Schizosaccharomyces pombe)

cog2 [Golgi membrane] (Dictyostelium discoideum)

cog2 [Golgi membrane] (Xenopus tropicalis)

cogc-2 [Golgi membrane] (Caenorhabditis elegans)

Cross References

ENSEMBL

ENST00000366669, ENST00000366668, ENSG00000135775, ENSP00000355629, ENSP00000355628

OpenTargets

ENSG00000135775

GeneCards

COG2

HPA

ENSG00000135775-COG2

PRO

Q14746

Pharos - Targets

Q14746

Orphanet

COG2

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P09917 ALOX5	6	p-S272-ALOX5 [nuclear envelope] (R-HSA-2318765) ALOX5 [cytosol] (R-HSA-429010) ALOX5 [ficolin-1-rich granule lumen] (R-HSA-6801302) ALOX5 [extracellular region] (R-HSA-6806468) ALOX5 [secretory granule lumen] (R-HSA-6801306) p-S272-ALOX5 [cytosol] (R-HSA-265276)	0.527	2
UniProt:P35414 APLNR	1	APLNR [plasma membrane] (R-HSA-374259)	0.527	2
UniProt:P08173 CHRM4	1	CHRM4 [plasma membrane] (R-HSA-390693)	0.527	2
UniProt:Q9NZQ7 CD274	1	CD274 [plasma membrane] (R-HSA-3211776)	0.527	2