Reactome | PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3)

PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3)

Stable Identifier

R-HSA-5216234

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A

ReviewStatus

5/5

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PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3)

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PRMT5 can methylate histone H2A at arginine-4 (H2AR3) (Pal et al. 2004). The histone-binding protein cooperator of PRMT5 (COPRS) guides PRMT5:WDR77 to methylate histone H4 arginine-4 (H4R3) rather than histone H3 arginine-9 (H3R8) (Lacroix et al. 2008) and may also be responsible for guiding PRMT5:WDR77 to methylate histone H2A arginine-4 (H2AR3).

Literature References

PubMed ID	Title	Journal	Year
18404153	The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5 Lacroix, M, El Messaoudi, S, Rodier, G, Le Cam, A, Sardet, C, Fabbrizio, E	EMBO Rep.	2008
15485929	Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes Pal, S, Vishwanath, SN, Erdjument-Bromage, H, Tempst, P, Sif, S	Mol. Cell. Biol.	2004