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p-Y31,Y118-PXN [cytosol]
Stable Identifier
R-HSA-5218693
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-Y31,Y118-Paxillin
Locations in the PathwayBrowser for interactor UniProt:Q14161 GIT2
Expand all
Signal Transduction (Homo sapiens)
Signaling by Non-Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PTK6 (Homo sapiens)
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Homo sapiens)
PTK6 phosphorylates PXN (Homo sapiens)
p-Y31,Y118-PXN [cytosol] (Homo sapiens)
Phosphorylated PXN recruits the CRK complex (Homo sapiens)
p-Y31,Y118-PXN [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P49023 PXN
Gene Names
PXN
Chain
initiator methionine:, chain:1-591
Reference Genes
BioGPS Gene:5829 PXN
COSMIC (genes):PXN PXN
CTD Gene:5829 PXN
dbSNP Gene:5829 PXN
ENSEMBL:ENSG00000089159 PXN
ENSEMBL_homo_sapiens_GENE:ENSG00000089159.17 PXN
HGNC:9718 PXN
KEGG Gene (Homo sapiens):5829 PXN
Monarch:5829 PXN
NCBI Gene:5829 PXN
OMIM:602505 PXN
UCSC:P49023 PXN
Reference Transcript
RefSeq:XM_017019743.1 PXN
RefSeq:NM_002859.3 PXN
RefSeq:NM_001080855.2 PXN
RefSeq:NM_025157.4 PXN
RefSeq:NM_001243756.1 PXN
Other Identifiers
11717617_a_at
11717618_s_at
11736017_s_at
11736018_x_at
11748796_a_at
11749054_x_at
11752827_a_at
11752828_x_at
16771242
201087_PM_at
201087_at
211823_PM_s_at
211823_s_at
3474373
3474374
3474375
3474376
3474377
3474378
3474379
3474380
3474384
3474385
3474386
3474387
3474388
3474390
3474402
3474403
3474404
3474405
3474406
3474407
3474416
3474417
38644_at
5829
7967002
A_24_P184555
A_33_P3380098
GE58953
GO:0001725
GO:0005515
GO:0005737
GO:0005829
GO:0005856
GO:0005875
GO:0005886
GO:0005911
GO:0005925
GO:0005938
GO:0007010
GO:0007155
GO:0007165
GO:0007172
GO:0007179
GO:0008013
GO:0008092
GO:0016477
GO:0017166
GO:0019903
GO:0023052
GO:0030027
GO:0034446
GO:0034614
GO:0038191
GO:0043226
GO:0043542
GO:0046872
GO:0048870
GO:0051496
GO:0060396
GO:0065003
GO:0070161
HMNXSV003050935
TC12002037.hg
U14588_at
g1912054_3p_a_at
g4506344_3p_at
Participates
as a component of
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
as an output of
PTK6 phosphorylates PXN (Homo sapiens)
as an input of
Phosphorylated PXN recruits the CRK complex (Homo sapiens)
Other forms of this molecule
p-Y-PXN [plasma membrane]
PXN [plasma membrane]
PXN [cytosol]
Inferred To
phospho-Pxn [cytosol]
(Mus musculus)
phospho-Pxn [cytosol]
(Rattus norvegicus)
Ghost homologue of p-Y31,Y118-PXN [cytosol]
(Caenorhabditis elegans)
Ghost homologue of p-Y31,Y118-PXN [cytosol]
(Xenopus tropicalis)
phospho-limB [cytosol]
(Dictyostelium discoideum)
phospho-Pax [cytosol]
(Drosophila melanogaster)
phospho-pxna [cytosol]
(Danio rerio)
phospho-p-Y31,Y118-PXN [cytosol]
(Gallus gallus)
phospho-PXN [cytosol]
(Bos taurus)
phospho-PXN [cytosol]
(Canis familiaris)
phospho-PXN [cytosol]
(Sus scrofa)
Modified Residues
Name
O4'-phospho-L-tyrosine at 31
Coordinate
31
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 118
Coordinate
118
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_079433.3
,
NP_001230685.1
,
NP_002850.2
,
NP_001074324.1
,
XP_016875232.1
OpenTargets
ENSG00000089159
HPA
ENSG00000089159-PXN
GeneCards
P49023
Ensembl
ENSG00000089159
,
ENSP00000395536
,
ENST00000424649
,
ENST00000228307
,
ENSP00000228307
,
ENST00000267257
,
ENST00000458477
,
ENSP00000267257
,
ENSP00000391283
PRO
P49023
Pharos - Targets
P49023
PDB
7QB0
,
4XH2
,
4R32
,
1OW7
,
2VZI
,
4EDN
,
6IUI
,
3RQG
,
6U4M
,
3RQF
,
6PW8
,
1OW8
,
4XGZ
,
2K2R
,
6U4N
,
2VZD
,
5UWH
,
3GM1
,
1OW6
,
2VZG
,
3RQE
,
2O9V
,
3PY7
,
3U3F
Interactors (25)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q05397 PTK2
11
pY-PTK2 [cytosol]
(R-HSA-9632393)
p-Y194,Y397,Y576,Y577-PTK2 [cytosol]
(R-HSA-8874613)
p-Y194,Y397-PTK2 [cytosol]
(R-HSA-8874600)
p-5Y-PTK2 [cytosol]
(R-HSA-5218711)
p-5Y,S732-PTK2 [cytosol]
(R-HSA-5229006)
p-6Y,S732-PTK2 [cytosol]
(R-HSA-5218694)
PTK2(773-1052) [cytosol]
(R-HSA-202829)
PTK2(1-772) [cytosol]
(R-HSA-202827)
PTK2 [cytosol]
(R-HSA-201621)
p-Y397-PTK2 [cytosol]
(R-HSA-354068)
p-6Y-PTK2 [cytosol]
(R-HSA-354128)
0.942
19
UniProt:Q05209 PTPN12
2
PTPN12 [cytosol]
(R-HSA-432933)
PTPN12 [nucleoplasm]
(R-HSA-9008905)
0.762
4
UniProt:P06931 VE6
0.744
4
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.706
12
UniProt:P13612 ITGA4
1
ITGA4 [plasma membrane]
(R-HSA-198007)
0.688
5
UniProt:Q14161 GIT2
1
GIT2 [cytosol]
(R-HSA-446034)
0.688
4
UniProt:Q13418 ILK
1
ILK [cytosol]
(R-HSA-432864)
0.669
4
UniProt:P41240 CSK
2
CSK [plasma membrane]
(R-HSA-180499)
CSK [cytosol]
(R-HSA-203776)
0.623
4
UniProt:Q62417-2 SORBS1
0.61
8
UniProt:Q06124 PTPN11
4
p-Y542-PTPN11 [cytosol]
(R-HSA-1369081)
PTPN11 [nucleoplasm]
(R-HSA-8937745)
PTPN11 [cytosol]
(R-HSA-162563)
p-Y542,Y580-PTPN11 [cytosol]
(R-HSA-162573)
0.604
3
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
0.602
4
UniProt:Q99942 RNF5
1
RNF5 [endoplasmic reticulum membrane]
(R-HSA-975990)
0.591
6
UniProt:Q9Y2X7 GIT1
2
GIT1 [cytosol]
(R-HSA-430326)
p-Y383-GIT1 [cytosol]
(R-HSA-3928463)
0.564
3
UniProt:Q96FJ2 DYNLL2
4
DYNLL2 [cytosol]
(R-HSA-2029024)
DYNLL2 [plasma membrane]
(R-HSA-140527)
DYNLL2 [cilium]
(R-HSA-5624865)
DYNLL2 [ciliary tip]
(R-HSA-5625337)
0.527
2
UniProt:Q96B26 EXOSC8
2
EXOSC8 [nucleoplasm]
(R-HSA-6791571)
EXOSC8 [cytosol]
(R-HSA-429912)
0.527
2
UniProt:Q14289 PTK2B
3
p-Y-PTK2B [cytosol]
(R-HSA-508515)
PTK2B [cytosol]
(R-HSA-390932)
PTK2B [cytosol]
(R-HSA-5218721)
0.527
2
UniProt:P63167 DYNLL1
6
DYNLL1 [ciliary tip]
(R-HSA-5625335)
DYNLL1 [cilium]
(R-HSA-5624863)
DYNLL1 [ficolin-1-rich granule membrane]
(R-HSA-6801518)
DYNLL1 [tertiary granule membrane]
(R-HSA-6801482)
DYNLL1 [plasma membrane]
(R-HSA-54017)
DYNLL1 [cytosol]
(R-HSA-387105)
0.527
2
UniProt:P12931 SRC
6
p-Y419-SRC [nucleoplasm]
(R-HSA-8937690)
SRC [cytosol]
(R-HSA-9628701)
p-Y419-SRC [cytosol]
(R-HSA-8964276)
MyrG-SRC [plasma membrane]
(R-HSA-8876922)
MyrG,p-Y530-SRC [plasma membrane]
(R-HSA-377598)
MyrG-p-Y419-SRC [plasma membrane]
(R-HSA-1810408)
0.527
2
UniProt:Q14155 ARHGEF7
1
ARHGEF7 [cytosol]
(R-HSA-430346)
0.527
3
UniProt:Q09463
2
rnf-5 [endoplasmic reticulum membrane]
(R-CEL-8861819)
rnf-5 [endoplasmic reticulum membrane]
(R-CEL-975990)
0.524
2
UniProt:Q13480 GAB1
4
GAB1 [cytosol]
(R-HSA-179795)
p-5Y-GAB1 [cytosol]
(R-HSA-180344)
p-Y627,Y659-GAB1 [cytosol]
(R-HSA-180496)
p-Y-GAB1 [cytosol]
(R-HSA-8855306)
0.499
2
UniProt:P02751 FN1
10
FN1(32-2386) [platelet alpha granule lumen]
(R-HSA-114620)
FN1(32-271) [extracellular region]
(R-HSA-3787935)
FN1(272-2386) [extracellular region]
(R-HSA-3788024)
FN1(32-?) [extracellular region]
(R-HSA-2533850)
FN1(?-2386) [extracellular region]
(R-HSA-2533841)
FN1(32-1201)-p-7Y-ALK(1022-1620) fusion [plasma membrane]
(R-HSA-9713462)
FN1(32-1201)-ALK(1022-1620) fusion [plasma membrane]
(R-HSA-9713459)
p-FN1 [endoplasmic reticulum lumen]
(R-HSA-8956937)
FN1 [endoplasmic reticulum lumen]
(R-HSA-8956708)
FN1(32-2386) [extracellular region]
(R-HSA-54851)
0.491
2
UniProt:O13016 PTN1
0.489
2
UniProt:P34152 Ptk2
13
phospho-pY-PTK2 [cytosol]
(R-MMU-9632393)
phospho-p-6Y-PTK2 [cytosol]
(R-MMU-354128)
phospho-p-Y397-PTK2 [cytosol]
(R-MMU-354068)
PTK2 [cytosol]
(R-MMU-201621)
PTK2(1-772) [cytosol]
(R-MMU-202827)
PTK2(773-1052) [cytosol]
(R-MMU-202829)
phospho-p-6Y,S732-PTK2 [cytosol]
(R-MMU-5218694)
phospho-p-5Y,S732-PTK2 [cytosol]
(R-MMU-5229006)
phospho-p-5Y-PTK2 [cytosol]
(R-MMU-5218711)
Fak1 [cytosol]
(R-MMU-3928448)
p-Y428-FAK1 [cytosol]
(R-MMU-3928397)
phospho-p-Y194,Y397-PTK2 [cytosol]
(R-MMU-8874600)
phospho-p-Y194,Y397,Y576,Y577-PTK2 [cytosol]
(R-MMU-8874613)
0.463
2
UniProt:P16671 CD36
5
CD36 [platelet alpha granule membrane]
(R-HSA-114687)
4xPalmC-CD36 [specific granule membrane]
(R-HSA-6806151)
CD36 [phagocytic vesicle]
(R-HSA-1236835)
4xPalmC-CD36 [endocytic vesicle membrane]
(R-HSA-2239449)
4xPalmC-CD36 [plasma membrane]
(R-HSA-51645)
0.462
2
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