Reactome | p-S15,S78,S82-HSP27 [cytosol]

p-S15,S78,S82-HSP27 [cytosol]

Stable Identifier

R-HSA-5218697

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

HSPB1, Heat shock protein beta-1, HSPB1_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q6P1L5 F117B

Expand all

External Reference Information

External Reference

UniProt:P04792 HSBP1

Gene Names

HSBP1, HSPB1, HSP27, HSP28

Chain

chain:1-205

Reference Genes

BioGPS Gene:3315 HSBP1

COSMIC (genes):HSBP1 HSBP1

CTD Gene:3315 HSBP1

dbSNP Gene:3315 HSBP1

ENSEMBL:ENSG00000106211 HSBP1

ENSEMBL_homo_sapiens_GENE:ENSG00000106211.10 HSBP1

HGNC:5246 HSBP1

KEGG Gene (Homo sapiens):3315 HSBP1

Monarch:3315 HSBP1

NCBI Gene:3315 HSBP1

OMIM:602195 HSBP1

Reference Transcript

RefSeq:NM_001540.3 HSBP1

Other Identifiers

11756054_x_at

17047504

17125292

17125294

201841_3p_s_at

201841_PM_s_at

201841_s_at

3009402

3009403

3009404

3009405

3009406

3009407

3009410

3009412

3009413

3009414

3009415

3209482

3315

36785_at

4008010

63673_at

8133721

A_23_P257704

A_24_P86537

GE79739

GO:0000502

GO:0001533

GO:0001932

GO:0003723

GO:0005080

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005819

GO:0005829

GO:0005856

GO:0005886

GO:0005925

GO:0006446

GO:0006457

GO:0006469

GO:0006886

GO:0006914

GO:0006986

GO:0007018

GO:0007155

GO:0008426

GO:0009408

GO:0009615

GO:0010506

GO:0012501

GO:0019901

GO:0023052

GO:0030018

GO:0032731

GO:0032760

GO:0035556

GO:0035924

GO:0036211

GO:0038033

GO:0042026

GO:0042060

GO:0042802

GO:0042803

GO:0043066

GO:0043122

GO:0043130

GO:0043226

GO:0043292

GO:0043536

GO:0044183

GO:0045766

GO:0048856

GO:0048870

GO:0051082

GO:0061077

GO:0061629

GO:0070062

GO:0070527

GO:0098772

GO:0099641

GO:1902176

GO:1904115

GO:2001028

GO:2001234

HMNXSV003032430

ILMN_1674236

PH_hs_0028972

TC07000485.hg

TC09002591.hg

Z23090_at

g4996892_3p_a_at

g4996892_3p_x_at

Participates

as an output of

p-MAPK2/3 phosphorylates HSP27 (Homo sapiens)

Other forms of this molecule

HSPB1 [cytosol]

p-S78,S82 HSPB1 [cytosol]

Inferred To

phospho-hsp-17 [cytosol] (Caenorhabditis elegans)

phospho-hsp-12.3 [cytosol] (Caenorhabditis elegans)

phospho-Hsp23 [cytosol] (Drosophila melanogaster)

phospho-Dmel\CG13133 [cytosol] (Drosophila melanogaster)

phospho-hsp-12.1 [cytosol] (Caenorhabditis elegans)

Homologues of p-S15,S78,S82-HSP27 [cytosol] (Caenorhabditis elegans)

Homologues of p-S15,S78,S82-HSP27 [cytosol] (Drosophila melanogaster)

phospho-Hsp26 [cytosol] (Drosophila melanogaster)

phospho-hsp-12.6 [cytosol] (Caenorhabditis elegans)

phospho-Hsp27 [cytosol] (Canis familiaris)

phospho-Hsp27 [cytosol] (Drosophila melanogaster)

phospho-hsp-16.2 [cytosol] (Caenorhabditis elegans)

phospho-Hsp67Bc [cytosol] (Drosophila melanogaster)

phospho-l(2)efl [cytosol] (Drosophila melanogaster)

phospho-Dmel\CG7409 [cytosol] (Drosophila melanogaster)

phospho-hsp-16.11 [cytosol] (Caenorhabditis elegans)

phospho-BEST:GH12586 [cytosol] (Drosophila melanogaster)

phospho-hsp-16.41 [cytosol] (Caenorhabditis elegans)

phospho-hsp-12.2 [cytosol] (Caenorhabditis elegans)

phospho-hspb1 [cytosol] (Danio rerio)

phospho-hspb1 [cytosol] (Xenopus tropicalis)

phospho-sip-1 [cytosol] (Caenorhabditis elegans)

phospho-hsp-43 [cytosol] (Caenorhabditis elegans)

phospho-HSPB1 [cytosol] (Bos taurus)

phospho-HSPB1 [cytosol] (Sus scrofa)

phospho-Hsp67Ba [cytosol] (Drosophila melanogaster)

phospho-hsp-16.48 [cytosol] (Caenorhabditis elegans)

phospho-Hsp22 [cytosol] (Drosophila melanogaster)

phospho-p-S15,S78,S82-HSP27 [cytosol] (Caenorhabditis elegans)

phospho-p-S15,S78,S82-HSP27 [cytosol] (Gallus gallus)

phospho-Hspb1 [cytosol] (Mus musculus)

phospho-Hspb1 [cytosol] (Rattus norvegicus)

Modified Residues

Name

O-phospho-L-serine at 15

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 78

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 82

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_001531.1

OpenTargets

ENSG00000230989

ZINC - Substances

HSPB1_HUMAN

ZINC target

P04792

PRO

P04792

PDB

2N3J, 3Q9Q, 6DV5, 6GJH, 4MJH, 3Q9P

ZINC - Investigational

HSPB1_HUMAN

HPA

ENSG00000106211-HSPB1

GeneCards

P04792

Ensembl

ENSP00000248553, ENSG00000106211, ENST00000248553

Pharos - Targets

P04792

ZINC - Predictions - Purchasable

HSPB1_HUMAN

Orphanet

16230

Interactors (237)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02511 CRYAB	1	CRYAB [nucleoplasm] (R-HSA-6806336)	0.876	8
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.831	12
UniProt:O95817 BAG3	1	BAG3 [cytosol] (R-HSA-5255451)	0.822	7
UniProt:P02489 CRYAA			0.815	7
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.706	21
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.678	4
UniProt:P08865 RPSA	2	RPSA [nucleoplasm] (R-HSA-6798722) RPSA [cytosol] (R-HSA-72389)	0.666	4
UniProt:Q9BRX2 PELO			0.666	4
UniProt:Q9BRX9 WDR83	1	WDR83 [endosome membrane] (R-HSA-5672942)	0.666	4
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.666	4
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.665	3
UniProt:Q9UER7 DAXX	13	monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX S138* [nucleoplasm] (R-HSA-9673081) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A36Qfs*108 [nucleoplasm] (R-HSA-9673105) DAXX [nucleoplasm] (R-HSA-3222068)	0.618	4
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.615	3
UniProt:Q9HBQ8 GGA2B			0.61	4
UniProt:P02562 MYSS			0.576	5
UniProt:P02602 MYL1			0.576	5
UniProt:Q16644 MAPKAPK3	4	MAPKAPK3 [cytosol] (R-HSA-187764) MAPKAPK3 [nucleoplasm] (R-HSA-450218) p-S,2T-MAPKAPK3 [nucleoplasm] (R-HSA-450359) p-S,2T-MAPKAPK3 [cytosol] (R-HSA-187723)	0.571	3
UniProt:P49137 MAPKAPK2	5	MAPKAPK2 [cytosol] (R-HSA-187743) p-T222,S272-MAPKAPK2 [nucleoplasm] (R-HSA-199936) p-S272,T222,T334-MAPKAPK2 [cytosol] (R-HSA-187760) p-T222,S272,T334-MAPKAPK2 [nucleoplasm] (R-HSA-450268) MAPKAPK2 [nucleoplasm] (R-HSA-450235)	0.571	3
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.564	2
UniProt:Q8IUI8 CRLF3			0.556	3
UniProt:Q96MN9-2 Q96MN92			0.556	3
UniProt:Q86V28 Q86V28			0.556	3
UniProt:Q96K21 ANCHR			0.556	3
UniProt:Q6PJW8-3 Q6PJW83			0.556	3
UniProt:Q9NSD5-3 Q9NSD53			0.556	3
UniProt:APLN D3DTF8			0.556	3
UniProt:Q9NTN9-3 SEMA4G			0.556	3
UniProt:Q6NTF9-3 Q6NTF93			0.556	3
UniProt:Q96D59 RN183			0.556	3
UniProt:Q8IZU1 FAM9A			0.556	3
UniProt:P11908 PRPS2	1	PRPS2 [cytosol] (R-HSA-58224)	0.556	3
UniProt:Q86TN1 Q86TN1			0.556	3
UniProt:Q9Y5P3 RAI2			0.556	3
UniProt:O15534 PER1	4	p-S-PER1 [cytosol] (R-HSA-400310) p-S-PER1 [nucleoplasm] (R-HSA-3325590) PER1 [cytosol] (R-HSA-400373) Ub-p-S-PER1 [cytosol] (R-HSA-517831)	0.556	3
UniProt:Q8N8A2-2 Q8N8A22			0.556	3
UniProt:Q99608 NDN	1	NDN [nucleoplasm] (R-HSA-6789966)	0.556	3
IntAct:EBI-25859406 CCSB			0.556	3
UniProt:Q14693 LPIN1	3	p-S106-LPIN1 [nucleoplasm] (R-HSA-4419936) LPIN1 [nuclear envelope] (R-HSA-4419927) LPIN1 [endoplasmic reticulum membrane] (R-HSA-549157)	0.556	3
UniProt:Q9H0W9-4 C11ORF54			0.556	3
UniProt:Q8N594 MPND			0.556	3
UniProt:P58304 VSX2			0.556	3
UniProt:Q14847-2 LASP1			0.556	3
UniProt:P08195-4 SLC3A2			0.556	3
UniProt:P0C870 JMJD7	1	JMJD7 [cytosol] (R-HSA-9629577)	0.556	3
UniProt:Q49AJ0-4 Q49AJ04			0.556	3
UniProt:Q96LB9 PGLYRP3	1	PGLYRP3 [extracellular region] (R-HSA-6799958)	0.556	3
UniProt:Q6P587-2 FAHD1			0.556	3
UniProt:Q96FW1 OTUB1	2	OTUB1 [cytosol] (R-HSA-933411) OTUB1 [nucleoplasm] (R-HSA-6783242)	0.556	3
UniProt:Q8N6K7-2 SAMD3			0.556	3
UniProt:Q6UXG2-3 ELAPOR1			0.556	3
UniProt:P08758 ANXA5	2	ANXA5 [extracellular region] (R-HSA-8862986) ANXA5 [cytosol] (R-HSA-8862945)	0.556	3
UniProt:P57682 KLF3			0.556	3
UniProt:Q7L8T7 Q7L8T7			0.556	3
UniProt:O00148 DDX39A	1	DDX39A [nucleoplasm] (R-HSA-8852237)	0.556	3
UniProt:P36406 TRI23			0.556	3
UniProt:Q86WV8 Q86WV8			0.556	3
UniProt:Q9NSI6-4 BRWD1			0.556	3
UniProt:Q9NXC2 GFOD1	1	GFOD1 [plasma membrane] (R-HSA-9714882)	0.556	3
IntAct:EBI-25840120 CCSB			0.556	3
UniProt:Q99932-2 SPAG8			0.556	3
UniProt:Q92688 AN32B			0.556	3
UniProt:Q8NBM4-4 Q8NBM44			0.556	3
UniProt:P51608 MECP2			0.556	3
IntAct:EBI-25836220 CCSB			0.556	3
UniProt:Q9Y2M5 KLHL20	1	KLHL20 [cytosol] (R-HSA-976032)	0.556	3
UniProt:A2RU56 A2RU56			0.556	3
UniProt:Q96N77-2 ZNF641			0.556	3
UniProt:Q5VWN6 TASO2			0.556	3
UniProt:A0A1B0GWI1 A0A1B0GWI1			0.556	3
UniProt:Q9BUF5 TUBB6	6	TUBB6 [cytosol] (R-HSA-191698) TUBB6 [axonemal microtubule] (R-HSA-5610438) Polyglutamyl-TUBB6 [cytosol] (R-HSA-8867399) Polyglycyl-TUBB6 [cytosol] (R-HSA-8867396) TUBB6 unfolded [cytosol] (R-HSA-392780) TUBB6 folding intermediate [cytosol] (R-HSA-392787)	0.556	3
UniProt:Q969T4 UBE2E3	4	UBE2E3 [cytosol] (R-HSA-947633) UBE2E3 [nucleoplasm] (R-HSA-8852108) Ub-C145-UBE2E3 [nucleoplasm] (R-HSA-8864208) Ub-C145-UBE2E3 [cytosol] (R-HSA-8864162)	0.556	3
UniProt:Q9UKP3-2 Q9UKP32			0.556	3
UniProt:Q8NBF2-2 NHLRC2			0.556	3
UniProt:Q9BS34 ZNF670	1	ZNF670 [nucleoplasm] (R-HSA-2248887)	0.556	3
UniProt:Q96FT7-4 ASIC4			0.556	3
UniProt:Q66K80 RUAS1			0.556	3
UniProt:Q96GL9 F163A			0.556	3
UniProt:Q99614 TTC1			0.556	3
UniProt:Q5TAQ9-2 Q5TAQ92			0.556	3
UniProt:O00757 FBP2	1	FBP2 [cytosol] (R-HSA-71500)	0.556	3
IntAct:EBI-25835277 CCSB			0.556	3
UniProt:Q9NP61 ARFGAP3	1	ARFGAP3 [cytosol] (R-HSA-6807740)	0.556	3
UniProt:Q53NU3 Q53NU3			0.556	3
UniProt:Q96A09 TET5B			0.556	3
UniProt:Q8NA54 IQUB			0.556	3
UniProt:Q96SI1-2 KCTD15			0.556	3
UniProt:Q9NZJ9 NUDT4	1	NUDT4 [cytosol] (R-HSA-1604676)	0.556	3
UniProt:Q96JB6 LOXL4	3	LOXL4(25-?) [extracellular region] (R-HSA-2022087) LOXL4 [extracellular region] (R-HSA-2022127) LOXL4(?-756) [extracellular region] (R-HSA-2022098)	0.556	3
UniProt:A0A0A0MR05 A0A0A0MR05			0.556	3
UniProt:Q6XD76 ASCL4			0.556	3
IntAct:EBI-25831465 CCSB			0.556	3
UniProt:Q3SY46 KRTAP13-3	1	KRTAP13-3 [cytosol] (R-HSA-6810267)	0.556	3
UniProt:O95872 GPAN1			0.556	3
UniProt:Q7L591-3 DOK3			0.556	3
IntAct:EBI-25857950 CCSB			0.556	3
UniProt:Q17RD7-3 Q17RD73			0.556	3
UniProt:Q13569 TDG	3	polySUMO2,3-K330-TDG [nucleoplasm] (R-HSA-4551628) monoSUMO1-K330-TDG [nucleoplasm] (R-HSA-4551718) TDG [nucleoplasm] (R-HSA-65812)	0.556	3
UniProt:Q9NXX0 Q9NXX0			0.556	3
UniProt:Q8TC84 FANK1			0.556	3
UniProt:Q8IXS7 Q8IXS7			0.556	3
UniProt:A0AVI4-2 A0AVI42			0.556	3
UniProt:Q2QGD7 ZXDC			0.556	3
UniProt:P15313 ATP6V1B1	1	ATP6V1B1 [cytosol] (R-HSA-912604)	0.556	3
UniProt:Q58EX7-2 Q58EX72			0.556	3
UniProt:Q96LL4 CH048			0.556	3
UniProt:Q8IYI0 SHLD1			0.556	3
UniProt:B7Z3E8 B7Z3E8			0.556	3
UniProt:Q5BJF6-2 ODF2			0.556	3
UniProt:O94778 AQP8	2	AQP8 [plasma membrane] (R-HSA-431756) AQP8 [mitochondrial inner membrane] (R-HSA-3779402)	0.556	3
UniProt:P45880 VDAC2	6	p-S65-Ub:VDAC2 [mitochondrial outer membrane] (R-HSA-9834982) K63polyUb-VDAC2 [mitochondrial outer membrane] (R-HSA-9843314) K48polyUb-VDAC2 [mitochondrial outer membrane] (R-HSA-9843321) Ub-VDAC2 [mitochondrial outer membrane] (R-HSA-9835025) VDAC2 [mitochondrial outer membrane] (R-HSA-5696880) PolyUb-VDAC2 [mitochondrial outer membrane] (R-HSA-6783185)	0.556	3
UniProt:Q6ZU52 K0408			0.556	3
IntAct:EBI-25870739 RZPDO834G0119D			0.556	3
UniProt:Q8TDP1 RNH2C			0.556	3
UniProt:Q3SYF9 KRTAP19-7	1	KRTAP19-7 [cytosol] (R-HSA-6810305)	0.556	3
UniProt:Q8WZ19 KCTD13	1	KCTD13 [cytosol] (R-HSA-9696533)	0.556	3
UniProt:P01040 CSTA	2	CSTA [cornified envelope] (R-HSA-8934840) CSTA [cytosol] (R-HSA-6814194)	0.556	3
UniProt:Q8WUY3 PRUN2			0.556	3
UniProt:Q8N6F8 MET27			0.556	3
UniProt:Q9Y3D0 CIAO2B	1	FAM96B [cytosol] (R-HSA-2161124)	0.556	3
UniProt:P28062-2 PSMB8			0.556	3
UniProt:O43741 PRKAB2	2	PRKAB2 [cytosol] (R-HSA-200413) PRKAB2 [nucleoplasm] (R-HSA-164096)	0.556	3
UniProt:Q6UY14-3 ADAMTSL4			0.556	3
UniProt:P21980-2 P219802			0.556	3
UniProt:P13928 ANXA8			0.556	3
UniProt:P46379-2 BAG6			0.556	3
UniProt:Q15049 MLC1			0.556	3
UniProt:Q8N5U6 RNF10			0.556	3
UniProt:Q6P1L5 F117B			0.556	3
UniProt:Q14995 NR1D2	1	NR1D2 [nucleoplasm] (R-HSA-375501)	0.556	3
IntAct:EBI-25839678 CCSB			0.556	3
UniProt:Q9Y3Q8 T22D4			0.556	3
UniProt:Q6ZTN6-2 ANKRD13D			0.556	3
IntAct:EBI-25849442 CCSB			0.556	3
UniProt:Q8NDP9 Q8NDP9			0.556	3
IntAct:EBI-25835866 CCSB			0.556	3
UniProt:Q9H9Q2 COPS7B	2	COPS7B [cytosol] (R-HSA-416966) COPS7B [nucleoplasm] (R-HSA-5697023)	0.556	3
UniProt:Q8N5S9-2 Q8N5S92			0.556	3
UniProt:O00303 EIF3F	1	EIF3F [cytosol] (R-HSA-72540)	0.556	3
UniProt:Q8IUR5-4 TMTC1			0.556	3
UniProt:Q8NA72-3 POC5			0.556	3
IntAct:EBI-25836274 CCSB			0.556	3
UniProt:O75604-3 USP2			0.556	3
UniProt:Q9UNS2 COPS3	2	COPS3 [cytosol] (R-HSA-416973) COPS3 [nucleoplasm] (R-HSA-5697017)	0.556	3
UniProt:Q9NVX7-2 Q9NVX72			0.556	3
UniProt:Q03112-9 Q031129			0.556	3
UniProt:P15976-2 GATA1			0.556	3
UniProt:Q9BPU6 DPYSL5	3	p-Y-DPYSL5 [cytosol] (R-HSA-399786) DPYSL5 [cytosol] (R-HSA-398138) p-S534-DPYSL5 [cytosol] (R-HSA-399793)	0.556	3
UniProt:Q9UF11-2 PLEKHB1			0.556	3
IntAct:EBI-25835770 CCSB			0.556	3
UniProt:O15381-5 O153815			0.556	3
UniProt:Q6RVD6 SPAT8			0.556	3
UniProt:P36639-4 NUDT1	1	NUDT1-4 [cytosol] (R-HSA-2395813)	0.556	3
UniProt:Q6ZR37 PKHG7			0.556	3
UniProt:Q92966 SNAPC3	1	SNAPC3 [nucleoplasm] (R-HSA-83727)	0.556	3
UniProt:O60830 TIMM17B	2	TIMM17B [mitochondrial intermembrane space] (R-HSA-1955371) TIMM17B [mitochondrial inner membrane] (R-HSA-1252138)	0.556	3
UniProt:Q8IYN2 TCAL8			0.556	3
UniProt:Q71RG4-4 Q71RG44			0.556	3
UniProt:Q9UDY8-2 MALT1			0.556	3
UniProt:Q04323-2 UBXN1			0.556	3
UniProt:Q8WVN8 UBE2Q2	2	Ub-C304-UBE2Q2 [cytosol] (R-HSA-8864218) UBE2Q2 [cytosol] (R-HSA-947618)	0.556	3
UniProt:A0A384ME25 A0A384ME25			0.556	3
IntAct:EBI-25861384 CCSB			0.556	3
UniProt:Q9UPM6 LHX6			0.556	3
UniProt:Q8N1A0 KT222			0.556	3
UniProt:Q9HC96 CAPN10	1	CAPN10 [cytosol] (R-HSA-8848640)	0.556	3
UniProt:Q8TCT7-2 SPPL2B			0.556	3
UniProt:Q17RN3 FA98C			0.556	3
UniProt:Q16670 ZSC26			0.556	3
UniProt:Q8IUC2 KRTAP8-1	1	KRTAP8-1 [cytosol] (R-HSA-6810288)	0.556	3
IntAct:EBI-25831516 CCSB			0.556	3
UniProt:Q96PV6 LENG8			0.556	3
IntAct:EBI-25835796 CCSB			0.556	3
UniProt:O77932 DXO			0.556	3
UniProt:Q9NZC7-5 WWOX			0.556	3
UniProt:Q9C004 SPY4			0.556	3
UniProt:O15287 FANCG	2	FANCG [nucleoplasm] (R-HSA-419532) FANCG [cytosol] (R-HSA-420788)	0.556	3
UniProt:Q5VYS8-5 TUT7			0.556	3
UniProt:Q9Y575-3 ASB3			0.556	3
IntAct:EBI-25848398 CCSB			0.556	3
UniProt:Q14005-2 Q140052			0.556	3
IntAct:EBI-25843264 CCSB			0.556	3
UniProt:Q6GQQ9-2 Q6GQQ92			0.556	3
UniProt:P61244-4 MAX			0.556	3
UniProt:Q7Z602 GP141			0.556	3
UniProt:hCG_41307 A0A024R1L7			0.556	3
IntAct:EBI-25851697 CCSB			0.556	3
UniProt:Q9Y4H4 GPSM3	1	GPSM3 [cytosol] (R-HSA-8949486)	0.556	3
UniProt:Q96EW2-2 Q96EW22			0.556	3
UniProt:Q9NUL5-3 SHFL			0.556	3
UniProt:Q9H1D9 POLR3F	2	POLR3F [cytosol] (R-HSA-1964434) POLR3F [nucleoplasm] (R-HSA-83708)	0.556	3
UniProt:Q8N448 LNX2			0.556	3
UniProt:O75925 PIAS1	1	PIAS1 [nucleoplasm] (R-HSA-877307)	0.556	3
UniProt:P47897 QARS1	2	QARS [cytosol] (R-HSA-379615) QARS [mitochondrial matrix] (R-HSA-379592)	0.556	3
UniProt:Q9UIH9 KLF15	1	KLF15 [nucleoplasm] (R-HSA-8878735)	0.556	3
UniProt:Q8TBF4 ZCRB1	2	ZCRB1 [cytosol] (R-HSA-9682010) ZCRB1 [nucleoplasm] (R-HSA-6787853)	0.556	3
UniProt:Q96LC9 BMF	3	p-BMF [mitochondrial outer membrane] (R-HSA-3145026) BMF [plasma membrane] (R-HSA-140209) p-BMF(1-89) [cytosol] (R-HSA-140529)	0.556	3
UniProt:Q6NXG1 ESRP1	3	ESRP1 [nucleoplasm] (R-HSA-6803472) ESRP1(1-606)-p-RAF1(227-648) fusion [cytosol] (R-HSA-6802523) ESRP1(1-606)-RAF1(227-648) fusion [cytosol] (R-HSA-6802312)	0.556	3
UniProt:P62333 PSMC6	2	PSMC6 [nucleoplasm] (R-HSA-174319) PSMC6 [cytosol] (R-HSA-68783)	0.556	3
UniProt:Q8NBJ7 SUMF2	1	SUMF2 [endoplasmic reticulum lumen] (R-HSA-1614305)	0.556	3
UniProt:P62979 RPS27A	20	RPS27A(1-76) [endocytic vesicle membrane] (R-HSA-939208) RPS27A(77-156) [nucleoplasm] (R-HSA-6798734) Ub-33-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783024) Ub-63-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783200) Ub-6-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783040) Ub-11-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783085) Ub-48-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783075) Ub-29-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783146) Ub-27-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783176) N6-glycyl-L-lysine-RPS27A(1-76) [cytosol] (R-HSA-8869045) adenylatedlG76-RPS27A(1-76) [nucleoplasm] (R-HSA-8852078) RPS27A [cytosol] (R-HSA-8853524) adenylatedlG76-RPS27A(1-76) [cytosol] (R-HSA-8852065) Ub-48-RPS27A(1-76) [endoplasmic reticulum membrane] (R-HSA-8943102) Ub-48-RPS27A(1-76) [lysosomal membrane] (R-HSA-9763033) Ub-48-RPS27A(1-76) [endocytic vesicle membrane] (R-HSA-9763012) RPS27A(1-76) [endosome membrane] (R-HSA-939238) RPS27A(1-76) [plasma membrane] (R-HSA-3149457) Ub-29-RPS27A(1-76) [cytosol] (R-HSA-5689223) Ub-6-RPS27A(1-76) [cytosol] (R-HSA-5689098)	0.556	3
UniProt:Q8N5V2 NGEF	2	NGEF [cytosol] (R-HSA-3006800) p-Y179-NGEF [cytosol] (R-HSA-3928441)	0.556	3
UniProt:Q06136 KDSR	1	KDSR [endoplasmic reticulum membrane] (R-HSA-428134)	0.556	3
UniProt:Q96FX8 PERP	1	PERP [plasma membrane] (R-HSA-6800837)	0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:Q86WV5 TEN1	1	TEN1 [nucleoplasm] (R-HSA-9668823)	0.556	3
UniProt:P62244 RPS15A	2	RPS15A [nucleoplasm] (R-HSA-6791191) RPS15A [cytosol] (R-HSA-72345)	0.556	3
UniProt:Q99683 MAP3K5	1	MAP3K5 [cytosol] (R-HSA-167709)	0.556	3
UniProt:Q96DZ5 CLIP3	1	CLIP3 [cytosol] (R-HSA-5212669)	0.556	3
UniProt:Q9BQA1 WDR77	3	WDR77 [nucleoplasm] (R-HSA-5205610) pT5-WDR77 [nucleoplasm] (R-HSA-5205602) WDR77 [cytosol] (R-HSA-191823)	0.556	3
UniProt:Q14457 BECN1	4	K63polyUb-BECN1 [cytosol] (R-HSA-6782989) ISG15-K-BECN1 [cytosol] (R-HSA-9853030) p-S15-BECN1 [cytosol] (R-HSA-5682391) BECN1 [cytosol] (R-HSA-1632841)	0.556	3
UniProt:Q16611 BAK1	2	BAK1 [mitochondrial outer membrane] (R-HSA-139896) BAK1 activated [mitochondrial outer membrane] (R-HSA-50690)	0.556	3
UniProt:P51114 FXR1	2	FXR1(2-784)-BRAF(381-766) fusion [cytosol] (R-HSA-6802326) FXR1(2-784)-p-BRAF(381-766) fusion [cytosol] (R-HSA-6802530)	0.553	2
UniProt:P35813 PPM1A	2	PPM1A [cytosol] (R-HSA-380928) PPM1A [nucleoplasm] (R-HSA-205813)	0.553	2
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.547	3
UniProt:P08473 MME	2	MME [plasma membrane] (R-HSA-2022342) MME [secretory granule membrane] (R-HSA-6806156)	0.537	4
UniProt:O14558 HSPB6			0.527	2
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.527	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.527	3
UniProt:Q14240 EIF4A2	1	EIF4A2 [cytosol] (R-HSA-72575)	0.508	2
UniProt:Q7Z6Z7 HUWE1	4	HUWE1 [secretory granule lumen] (R-HSA-6801481) HUWE1 [extracellular region] (R-HSA-6806466) HUWE1 [ficolin-1-rich granule lumen] (R-HSA-6801467) HUWE1 [cytosol] (R-HSA-975983)	0.508	3
UniProt:P13693 TCTP			0.508	2
UniProt:P02794 FTH1	5	FTH1 [ficolin-1-rich granule lumen] (R-HSA-6801531) FTH1 [tertiary granule lumen] (R-HSA-6801508) FTH1 [cytosol] (R-HSA-434212) FTH1 [endocytic vesicle lumen] (R-HSA-2299670) FTH1 [extracellular region] (R-HSA-2187212)	0.508	2
UniProt:Q9Y657 SPIN1			0.508	2
UniProt:P13010 XRCC5	4	XRCC5 [extracellular region] (R-HSA-6806530) XRCC5 [secretory granule lumen] (R-HSA-6801297) XRCC5 [cytosol] (R-HSA-3134849) XRCC5 [nucleoplasm] (R-HSA-58274)	0.508	2
UniProt:Q8N7H5 PAF1	1	PAF1 [nucleoplasm] (R-HSA-8866689)	0.508	2
UniProt:P78318 IGBP1			0.508	3
UniProt:Q86YS6 RAB43	3	RAB43 [trans-Golgi network membrane] (R-HSA-6814810) GGC-RAB43 [cytosol] (R-HSA-8874038) RAB43 [cytosol] (R-HSA-6813902)	0.508	2
UniProt:Q96G03 PGM2	4	PGM2 [cytosol] (R-HSA-453136) PGM2 [secretory granule lumen] (R-HSA-6801502) PGM2 [extracellular region] (R-HSA-6806446) PGM2 [ficolin-1-rich granule lumen] (R-HSA-6801476)	0.508	2
UniProt:P78417 GSTO1	1	GSTO1 [cytosol] (R-HSA-176043)	0.508	2
UniProt:Q15029 EFTUD2	1	EFTUD2 [nucleoplasm] (R-HSA-71883)	0.508	2
UniProt:P78344 EIF4G2	1	EIF4G2 [cytosol] (R-HSA-1678826)	0.508	3
UniProt:Q12874 SF3A3	1	SF3A3 [nucleoplasm] (R-HSA-71966)	0.508	2
UniProt:O00273 DFFA	6	DFFA [cytosol] (R-HSA-211221) DFFA(1-?) [nucleoplasm] (R-HSA-211228) DFFA(225-331) [nucleoplasm] (R-HSA-211188) DFFA(118-224) [nucleoplasm] (R-HSA-211205) DFFA(118-331) [nucleoplasm] (R-HSA-211199) DFFA(1-117) [nucleoplasm] (R-HSA-211185)	0.508	2
UniProt:P27797 CALR	6	CALR [lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448) CALR [endoplasmic reticulum lumen] (R-HSA-195905) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [phagocytic vesicle membrane] (R-HSA-1236879)	0.508	2
UniProt:Q02790 FKBP4	3	FKBP4 [nucleoplasm] (R-HSA-8939162) FKBP4 [nucleoplasm] (R-HSA-5324621) FKBP4 [cytosol] (R-HSA-5618108)	0.508	2
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 [cytosol] (R-HSA-9841264) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357)	0.483	3
UniProt:Q9UJY1 HSPB8	1	HSPB8 [nucleoplasm] (R-HSA-6806337)	0.454	3

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