Reactome | p-T410,T563-PRKCZ [cytosol]

p-T410,T563-PRKCZ [cytosol]

Stable Identifier

R-HSA-5218698

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

nPKC-zeta

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q05513 PRKCZ

Gene Names

PRKCZ, PKC2

Chain

chain:1-592

Reference Genes

COSMIC (genes):PRKCZ PRKCZ

dbSNP Gene:5590 PRKCZ

ENSEMBL:ENSG00000067606 PRKCZ

Participates

as a member of

p-PKC [cytosol] (Homo sapiens)

Other forms of this molecule

pS, p-T410-PRKCZ [cytosol]

PRKCZ [cytosol]

p-T410-PRKCZ [cytosol]

PRKCZ [cell junction]

Inferred To

phospho-PRKCZ [cytosol] (Gallus gallus)

Homologues of p-T410,T563-PRKCZ [cytosol] (Dictyostelium discoideum)

Homologues of p-T410,T563-PRKCZ [cytosol] (Schizosaccharomyces pombe)

phospho-p-T410,T563-PRKCZ [cytosol] (Bos taurus)

phospho-p-T410,T563-PRKCZ [cytosol] (Caenorhabditis elegans)

phospho-p-T410,T563-PRKCZ [cytosol] (Canis familiaris)

phospho-p-T410,T563-PRKCZ [cytosol] (Dictyostelium discoideum)

phospho-p-T410,T563-PRKCZ [cytosol] (Drosophila melanogaster)

phospho-p-T410,T563-PRKCZ [cytosol] (Mus musculus)

phospho-p-T410,T563-PRKCZ [cytosol] (Rattus norvegicus)

phospho-p-T410,T563-PRKCZ [cytosol] (Saccharomyces cerevisiae)

phospho-p-T410,T563-PRKCZ [cytosol] (Schizosaccharomyces pombe)

phospho-p-T410,T563-PRKCZ [cytosol] (Sus scrofa)

Modified Residues

Name

O-phospho-L-threonine at 410

Coordinate

410

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-threonine at 560

Coordinate

560

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Interactors (27)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BYG5 PARD6B	2	PARD6B [plasma membrane] (R-HSA-418193) PARD6B [cytosol] (R-HSA-419973)	0.949	18
UniProt:Q9NPB6 PARD6A	4	PARD6A [plasma membrane] (R-HSA-418187) PARD6A [cytosol] (R-HSA-420001) PARD6A [cell junction] (R-HSA-2134480) p-S345-PARD6A [plasma membrane] (R-HSA-2134533)	0.906	10
UniProt:Q9BYG4 PARD6G	2	PARD6G [plasma membrane] (R-HSA-418192) PARD6G [cytosol] (R-HSA-419967)	0.886	9
UniProt:P41743 PRKCI	3	PRKCI [nucleoplasm] (R-HSA-9021345) PRKCI [cytosol] (R-HSA-58206) PRKCI [plasma membrane] (R-HSA-420005)	0.886	10
UniProt:Q15334 L2GL1			0.837	9
UniProt:Q6P1M3 L2GL2			0.725	8
UniProt:O75323 GBAS	1	NIPSNAP2 [cytosol] (R-HSA-9714668)	0.725	5
UniProt:Q13501 SQSTM1	7	SQSTM1 [cytosol] (R-HSA-193937) SQSTM1 [nucleoplasm] (R-HSA-210961) ub K420 p-S349 SQSTM1 [cytosol] (R-HSA-9766536) p-S349 SQSTM1 [cytosol] (R-HSA-9766524) K7 ub-SQSTM1 [cytosol] (R-HSA-9759088) SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711954) SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711967)	0.725	6
UniProt:Q07021 C1QBP	3	C1QBP [plasma membrane] (R-HSA-158123) C1QBP [mitochondrial matrix] (R-HSA-9645697) C1QBP [cytosol] (R-HSA-9645690)	0.669	4
UniProt:Q15109 AGER	1	AGER [plasma membrane] (R-HSA-197639)	0.612	6
UniProt:P49757-1 NUMB			0.602	4
UniProt:Q04759 PRKCQ	9	p-Y90,T538,S676,S695-PRKCQ [plasma membrane] (R-HSA-202152) p-Y90-PRKCQ [plasma membrane] (R-HSA-202395) PRKCQ [plasma membrane] (R-HSA-202346) PRKQC closed conformation [cytosol] (R-HSA-202185) PRKCQ [cytosol] (R-HSA-58216) PRKCQ(355-706) [cytosol] (R-HSA-212514) PRKCQ(1-354) [cytosol] (R-HSA-212526) p-Y90,T219,T538,S676,S695-PRKCQ [plasma membrane] (R-HSA-2685606) PRKCQ [photoreceptor disc membrane] (R-HSA-2648997)	0.581	3
UniProt:P14598 NCF1	4	p-S345-NCF1 [cytosol] (R-HSA-9626824) p-6S-NCF1 [cytosol] (R-HSA-9626854) NCF1 [cytosol] (R-HSA-1222296) p-6S-NCF1 [phagolysosome] (R-HSA-1996220)	0.556	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.544	2
UniProt:Q9Y624 F11R	2	F11R [cell junction] (R-HSA-2134498) F11R [plasma membrane] (R-HSA-197845)	0.536	2
UniProt:P40939 HADHA	1	HADHA [mitochondrial inner membrane] (R-HSA-77264)	0.527	2
UniProt:Q9Y5S2 CDC42BPB	1	CDC42BPB [cytosol] (R-HSA-419873)	0.527	2
UniProt:P61289 PSME3	1	PSME3 [cytosol] (R-HSA-68816)	0.527	3
UniProt:P55084 HADHB	1	HADHB [mitochondrial inner membrane] (R-HSA-77266)	0.527	2
UniProt:Q8WV44 TRIM41	1	TRIM41 [cytosol] (R-HSA-5688975)	0.527	2
UniProt:Q8IX03 WWC1	1	WWC1 [cytosol] (R-HSA-2038400)	0.527	4
UniProt:O43852 CALU	3	CALU [extracellular region] (R-HSA-350739) p-CALU [endoplasmic reticulum lumen] (R-HSA-8956931) CALU [endoplasmic reticulum lumen] (R-HSA-350695)	0.527	2
UniProt:O00410 IPO5	1	IPO5 [nucleoplasm] (R-HSA-192675)	0.527	2
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.524	2
UniProt:O95999 BCL10	3	K48polyUb-BCL10 [cytosol] (R-HSA-8939329) BCL10 [cytosol] (R-HSA-202447) p-BCL10 [cytosol] (R-HSA-202488)	0.518	3
UniProt:P40337 VHL	3	monoSUMO1-K159,171,196-VHL [nucleoplasm] (R-HSA-4551697) VHL [nucleoplasm] (R-HSA-1234127) VHL [cytosol] (R-HSA-391423)	0.463	3

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