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CYBB [plasma membrane]
Stable Identifier
R-HSA-5218720
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
gp91phox, NOX2
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of specific granule membrane proteins (Homo sapiens)
Specific granule membrane proteins [plasma membrane] (Homo sapiens)
CYBB [plasma membrane] (Homo sapiens)
Exocytosis of tertiary granule membrane proteins (Homo sapiens)
Tertiary granule membrane proteins [plasma membrane] (Homo sapiens)
CYBB [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
NADPH oxidase 2 (NOX2) complex binds RAC1 (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
Cytochrome b-245 [plasma membrane] (Homo sapiens)
CYBB [plasma membrane] (Homo sapiens)
NOX2 complex:RAC1:GTP [plasma membrane] (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
Cytochrome b-245 [plasma membrane] (Homo sapiens)
CYBB [plasma membrane] (Homo sapiens)
NADPH oxidase 2 generates superoxide from oxygen (Homo sapiens)
NOX2 complex:RAC1:GTP [plasma membrane] (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
Cytochrome b-245 [plasma membrane] (Homo sapiens)
CYBB [plasma membrane] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate NADPH Oxidases (Homo sapiens)
NADPH oxidase 2 (NOX2) complex binds RAC1 (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
Cytochrome b-245 [plasma membrane] (Homo sapiens)
CYBB [plasma membrane] (Homo sapiens)
NOX2 complex:RAC1:GTP [plasma membrane] (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
Cytochrome b-245 [plasma membrane] (Homo sapiens)
CYBB [plasma membrane] (Homo sapiens)
NADPH oxidase 2 generates superoxide from oxygen (Homo sapiens)
NOX2 complex:RAC1:GTP [plasma membrane] (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
Cytochrome b-245 [plasma membrane] (Homo sapiens)
CYBB [plasma membrane] (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 binds effectors at the plasma membrane (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
Cytochrome b-245 [plasma membrane] (Homo sapiens)
CYBB [plasma membrane] (Homo sapiens)
RAC1:GTP:RAC1 effectors [plasma membrane] (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
Cytochrome b-245 [plasma membrane] (Homo sapiens)
CYBB [plasma membrane] (Homo sapiens)
RAC3 GTPase cycle (Homo sapiens)
RAC3 binds effectors at the plasma membrane (Homo sapiens)
RAC3 effectors [cytosol] (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
Cytochrome b-245 [plasma membrane] (Homo sapiens)
CYBB [plasma membrane] (Homo sapiens)
RAC3:GTP:RAC3 effectors [plasma membrane] (Homo sapiens)
RAC3 effectors [cytosol] (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
Cytochrome b-245 [plasma membrane] (Homo sapiens)
CYBB [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P04839 CYBB
Gene Names
CYBB, NOX2
Chain
initiator methionine:, chain:2-570
Reference Genes
BioGPS Gene:1536 CYBB
COSMIC (genes):CYBB CYBB
CTD Gene:1536 CYBB
dbSNP Gene:1536 CYBB
ENSEMBL:ENSG00000165168 CYBB
ENSEMBL_homo_sapiens_GENE:ENSG00000165168.9 CYBB
HGNC:2578 CYBB
KEGG Gene (Homo sapiens):1536 CYBB
Monarch:1536 CYBB
NCBI Gene:1536 CYBB
OMIM:300481 CYBB
UCSC:P04839 CYBB
Reference Transcript
RefSeq:NM_000397.3 CYBB
Other Identifiers
11727876_at
11749827_a_at
11751821_a_at
11758263_s_at
1536
17102538
203922_PM_s_at
203922_s_at
203923_3p_s_at
203923_PM_s_at
203923_s_at
37975_at
3973840
3973841
3973843
3973844
3973846
3973853
3973855
3973859
3973862
3973864
3973865
3973866
3973869
3973870
3973872
3973875
3973876
3973877
3973878
8166730
A_24_P365767
GE59656
GO:0002376
GO:0003824
GO:0005515
GO:0005634
GO:0005635
GO:0005737
GO:0005783
GO:0005789
GO:0005886
GO:0006091
GO:0006801
GO:0006811
GO:0006952
GO:0006954
GO:0007584
GO:0009055
GO:0009410
GO:0016020
GO:0016175
GO:0016491
GO:0020037
GO:0022900
GO:0023052
GO:0030425
GO:0030670
GO:0031410
GO:0032760
GO:0034220
GO:0034702
GO:0035579
GO:0042554
GO:0043020
GO:0043025
GO:0043226
GO:0045087
GO:0045335
GO:0045730
GO:0045766
GO:0046872
GO:0046982
GO:0048856
GO:0050660
GO:0050664
GO:0050665
GO:0055085
GO:0070821
GO:0071276
GO:0071361
GO:0071456
GO:0072593
GO:0097038
GO:0097411
GO:0098542
GO:1904044
GO:1904845
GO:1990776
HMNXSV003025118
Hs.88974.0.S1_3p_a_at
PH_hs_0004967
TC0X000171.hg
X04011_at
g6996020_3p_a_at
Participates
as a component of
Cytochrome b-245 [plasma membrane] (Homo sapiens)
as a member of
Specific granule membrane proteins [plasma membrane] (Homo sapiens)
Tertiary granule membrane proteins [plasma membrane] (Homo sapiens)
Other forms of this molecule
CYBB [specific granule membrane]
CYBB [tertiary granule membrane]
CYBB [endoplasmic reticulum membrane]
CYBB [phagocytic vesicle membrane]
Inferred To
Nox2 [plasma membrane]
(Canis familiaris)
cybb [plasma membrane]
(Xenopus tropicalis)
Homologues of CYBB [plasma membrane]
(Dictyostelium discoideum)
Homologues of CYBB [plasma membrane]
(Saccharomyces cerevisiae)
Cybb [plasma membrane]
(Rattus norvegicus)
zgc:64144 [plasma membrane]
(Danio rerio)
AIM14 [plasma membrane]
(Saccharomyces cerevisiae)
CYBB [plasma membrane]
(Bos taurus)
CYBB [plasma membrane]
(Dictyostelium discoideum)
CYBB [plasma membrane]
(Gallus gallus)
CYBB [plasma membrane]
(Mus musculus)
CYBB [plasma membrane]
(Saccharomyces cerevisiae)
CYBB [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_000388.2
Guide to Pharmacology - Targets
3002
OpenTargets
ENSG00000165168
ZINC - Substances
CY24B_HUMAN
ZINC target
P04839
PRO
P04839
PDB
8GZ3
,
7U8G
,
3A1F
GeneCards
P04839
HPA
ENSG00000165168-CYBB
Ensembl
ENSP00000367851
,
ENSG00000165168
,
ENST00000378588
Pharos - Targets
P04839
ZINC - Predictions - Purchasable
CY24B_HUMAN
Orphanet
15831
HMDB Protein
HMDBP01763
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