Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
CYBA [plasma membrane]
Stable Identifier
R-HSA-5218744
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
p22phox
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Killing mechanisms (Homo sapiens)
WNT5:FZD7-mediated leishmania damping (Homo sapiens)
NOX1 complex:pp-DVL:RAC1:GTP generates superoxide from oxygen (Homo sapiens)
NOX1 complex:WNT5:FZD7:pp-DVL:RAC1:GTP [plasma membrane] (Homo sapiens)
NOX1 Complex [plasma membrane] (Homo sapiens)
CYBA [plasma membrane] (Homo sapiens)
ppDVL:RAC1:GTP binds NOX1 complex (Homo sapiens)
NOX1 Complex [plasma membrane] (Homo sapiens)
CYBA [plasma membrane] (Homo sapiens)
NOX1 complex:WNT5:FZD7:pp-DVL:RAC1:GTP [plasma membrane] (Homo sapiens)
NOX1 Complex [plasma membrane] (Homo sapiens)
CYBA [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of specific granule membrane proteins (Homo sapiens)
Specific granule membrane proteins [plasma membrane] (Homo sapiens)
CYBA [plasma membrane] (Homo sapiens)
Exocytosis of tertiary granule membrane proteins (Homo sapiens)
Tertiary granule membrane proteins [plasma membrane] (Homo sapiens)
CYBA [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
NADPH oxidase 2 (NOX2) complex binds RAC1 (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
Cytochrome b-245 [plasma membrane] (Homo sapiens)
CYBA [plasma membrane] (Homo sapiens)
NOX2 complex:RAC1:GTP [plasma membrane] (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
Cytochrome b-245 [plasma membrane] (Homo sapiens)
CYBA [plasma membrane] (Homo sapiens)
NADPH oxidase 2 generates superoxide from oxygen (Homo sapiens)
NOX2 complex:RAC1:GTP [plasma membrane] (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
Cytochrome b-245 [plasma membrane] (Homo sapiens)
CYBA [plasma membrane] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate NADPH Oxidases (Homo sapiens)
NADPH oxidase 2 (NOX2) complex binds RAC1 (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
Cytochrome b-245 [plasma membrane] (Homo sapiens)
CYBA [plasma membrane] (Homo sapiens)
NOX2 complex:RAC1:GTP [plasma membrane] (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
Cytochrome b-245 [plasma membrane] (Homo sapiens)
CYBA [plasma membrane] (Homo sapiens)
NADPH oxidase 2 generates superoxide from oxygen (Homo sapiens)
NOX2 complex:RAC1:GTP [plasma membrane] (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
Cytochrome b-245 [plasma membrane] (Homo sapiens)
CYBA [plasma membrane] (Homo sapiens)
NOX1 complex:RAC1:GTP generates superoxide from oxygen (Homo sapiens)
NOX1 complex:RAC1:GTP [plasma membrane] (Homo sapiens)
NOX1 Complex [plasma membrane] (Homo sapiens)
CYBA [plasma membrane] (Homo sapiens)
NOX3 complex:RAC1:GTP generates superoxide from oxygen (Homo sapiens)
NOX3 complex:RAC1:GTP [plasma membrane] (Homo sapiens)
NOX3 Complex [plasma membrane] (Homo sapiens)
CYBA [plasma membrane] (Homo sapiens)
RAC1:GTP binds NOX1 complex (Homo sapiens)
NOX1 Complex [plasma membrane] (Homo sapiens)
CYBA [plasma membrane] (Homo sapiens)
NOX1 complex:RAC1:GTP [plasma membrane] (Homo sapiens)
NOX1 Complex [plasma membrane] (Homo sapiens)
CYBA [plasma membrane] (Homo sapiens)
RAC1:GTP binds NOX3 complex (Homo sapiens)
NOX3 Complex [plasma membrane] (Homo sapiens)
CYBA [plasma membrane] (Homo sapiens)
NOX3 complex:RAC1:GTP [plasma membrane] (Homo sapiens)
NOX3 Complex [plasma membrane] (Homo sapiens)
CYBA [plasma membrane] (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 binds effectors at the plasma membrane (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
NOX1 Complex [plasma membrane] (Homo sapiens)
CYBA [plasma membrane] (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
Cytochrome b-245 [plasma membrane] (Homo sapiens)
CYBA [plasma membrane] (Homo sapiens)
NOX3 Complex [plasma membrane] (Homo sapiens)
CYBA [plasma membrane] (Homo sapiens)
RAC1:GTP:RAC1 effectors [plasma membrane] (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
NOX1 Complex [plasma membrane] (Homo sapiens)
CYBA [plasma membrane] (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
Cytochrome b-245 [plasma membrane] (Homo sapiens)
CYBA [plasma membrane] (Homo sapiens)
NOX3 Complex [plasma membrane] (Homo sapiens)
CYBA [plasma membrane] (Homo sapiens)
RAC3 GTPase cycle (Homo sapiens)
RAC3 binds effectors at the plasma membrane (Homo sapiens)
RAC3 effectors [cytosol] (Homo sapiens)
NOX1 Complex [plasma membrane] (Homo sapiens)
CYBA [plasma membrane] (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
Cytochrome b-245 [plasma membrane] (Homo sapiens)
CYBA [plasma membrane] (Homo sapiens)
NOX3 Complex [plasma membrane] (Homo sapiens)
CYBA [plasma membrane] (Homo sapiens)
RAC3:GTP:RAC3 effectors [plasma membrane] (Homo sapiens)
RAC3 effectors [cytosol] (Homo sapiens)
NOX1 Complex [plasma membrane] (Homo sapiens)
CYBA [plasma membrane] (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
Cytochrome b-245 [plasma membrane] (Homo sapiens)
CYBA [plasma membrane] (Homo sapiens)
NOX3 Complex [plasma membrane] (Homo sapiens)
CYBA [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P13498 CYBA
Gene Names
CYBA
Chain
initiator methionine:1, chain:2-195
Reference Genes
BioGPS Gene:1535 CYBA
COSMIC (genes):CYBA CYBA
CTD Gene:1535 CYBA
dbSNP Gene:1535 CYBA
ENSEMBL:ENSG00000051523 CYBA
HGNC:2577 CYBA
KEGG:hsa:1535 CYBA
Monarch:1535 CYBA
NCBI Entrez Gene:1535 CYBA
OMIM:608508 CYBA
UCSC:P13498 CYBA
Reference Transcript
RefSeq:NM_000101.4 CYBA
Other Identifiers
11743968_a_at
1535
16829130
203028_PM_s_at
203028_s_at
229445_PM_at
229445_at
35807_at
3704271
3704272
3704273
3704274
3704275
3704276
3704277
3704278
3704279
3704280
3704281
3704282
3704283
3704284
3704285
3704286
3704287
3704291
3704297
3704298
8003322
91441_at
A_23_P163506
A_23_P315651
A_33_P3372332
GE80157
GO:0001666
GO:0001725
GO:0001938
GO:0002376
GO:0003012
GO:0003106
GO:0005515
GO:0005737
GO:0005768
GO:0005789
GO:0005886
GO:0005925
GO:0006801
GO:0006954
GO:0009055
GO:0009410
GO:0014823
GO:0014895
GO:0016020
GO:0016175
GO:0016324
GO:0016491
GO:0017004
GO:0017124
GO:0020037
GO:0030141
GO:0030307
GO:0030425
GO:0030670
GO:0031667
GO:0032755
GO:0032760
GO:0032930
GO:0034137
GO:0035579
GO:0042554
GO:0043020
GO:0043025
GO:0045087
GO:0045730
GO:0045777
GO:0046872
GO:0046982
GO:0048661
GO:0050665
GO:0050766
GO:0050886
GO:0051279
GO:0051649
GO:0065003
GO:0070254
GO:0070257
GO:0070555
GO:0070821
GO:0071260
GO:0071333
GO:0071356
GO:0071480
GO:0072593
GO:0097038
GO:0098542
GO:1900426
GO:1903428
GO:1904044
GO:1904385
GO:1904628
GO:1904845
HMNXSV003037704
Hs.174074.0.A1_3p_at
Hs.174074.0.A1_3p_x_at
ILMN_1744604
M21186_at
PH_hs_0004090
TC16001339.hg
g4557504_3p_s_at
p25971
Participates
as a member of
Specific granule membrane proteins [plasma membrane] (Homo sapiens)
Tertiary granule membrane proteins [plasma membrane] (Homo sapiens)
as a component of
NOX1 Complex [plasma membrane] (Homo sapiens)
NOX3 Complex [plasma membrane] (Homo sapiens)
Cytochrome b-245 [plasma membrane] (Homo sapiens)
Other forms of this molecule
CYBA [specific granule membrane]
CYBA [tertiary granule membrane]
CYBA [endoplasmic reticulum membrane]
CYBA [phagocytic vesicle membrane]
Inferred To
Cyba [plasma membrane]
(Mus musculus)
Cyba [plasma membrane]
(Rattus norvegicus)
CYBA [plasma membrane]
(Bos taurus)
CYBA [plasma membrane]
(Canis familiaris)
CYBA [plasma membrane]
(Gallus gallus)
CYBA [plasma membrane]
(Sus scrofa)
cyba [plasma membrane]
(Danio rerio)
cyba [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_000092.2
ENSEMBL
ENSG00000051523
,
ENSP00000261623
,
ENST00000261623
OpenTargets
ENSG00000051523
GeneCards
CYBA
HPA
ENSG00000051523-CYBA
PRO
P13498
Pharos - Targets
P13498
Orphanet
CYBA
HMDB Protein
HMDBP02596
PDB
7U8G
,
7YXW
,
1WLP
,
8WEJ
,
8GZ3
,
8X2L
,
8KEI
© 2025
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text