Activated ROCK directly phosphorylates FAK1 on S732. This phosphorylation induces a conformational change that is necessary to trigger the phosphorylation of FAK on Y407 (Le Bouef et al. 2006).
Le Boeuf, F,
protein serine/threonine kinase activity of RHOA:GTP:Mg2+:Activated ROCK1,ROCK2 [cytosol]