NADPH oxidase 2 generates superoxide from oxygen

Stable Identifier
R-HSA-5218841
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane, extracellular region
ReviewStatus
5/5
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NADPH oxidase 2 generates superoxide from oxygen
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The activated NOX2 complex generates superoxide (O2.-) by transferring an electron from NADPH in the cytosol to oxygen on the luminal or extracellular space (Bedard & Krause 2007).
Literature References
PubMed ID Title Journal Year
17237347 The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology

Bedard, K, Krause, KH

Physiol. Rev. 2007
Participants
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Output
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as an event of
Catalyst Activity

superoxide-generating NAD(P)H oxidase activity of NOX2 complex:RAC1:GTP [plasma membrane]

Physical Entity
NOX2 complex:RAC1:GTP [plasma membrane] (Homo sapiens)
Activity
superoxide-generating NAD(P)H oxidase activity (GO:0016175)
Orthologous Events
NADPH oxidase 2 generates superoxide from oxygen (Bos taurus)
NADPH oxidase 2 generates superoxide from oxygen (Canis familiaris)
NADPH oxidase 2 generates superoxide from oxygen (Danio rerio)
NADPH oxidase 2 generates superoxide from oxygen (Gallus gallus)
NADPH oxidase 2 generates superoxide from oxygen (Mus musculus)
NADPH oxidase 2 generates superoxide from oxygen (Rattus norvegicus)
NADPH oxidase 2 generates superoxide from oxygen (Sus scrofa)
NADPH oxidase 2 generates superoxide from oxygen (Xenopus tropicalis)
Cross References
Rhea
Authored
Garapati, P V  (2013-08-30)
Reviewed
Rivero Crespo, F  (2014-12-26)
Ballmer-Hofer, K  (2014-05-12)
Welsh, M  (2014-05-12)
Berger, P  (2014-05-12)
Created
Garapati, P V  (2013-12-19)
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