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p-6Y-VEGFR2 binds PI3K
Stable Identifier
R-HSA-5218852
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
p-6Y-VEGFR2 binds PI3K (Homo sapiens)
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Activation of VEGFR2 results in the activation of phosphatidylinositol 3-kinase (PI3K) which plays an important role in regulating endothelial proliferation, migration and survival (Jiang et al. 2000). Activation of PI3K is also essential for VEGF-stimulated nitric oxide (NO) production from endothelial cells via protein kinase B (PKB/AKT) signaling to eNOS (Nitric oxide synthase, endothelial) (Blanes et al. 2007). Upon stimulation by VEGF the p85 regulatory subunit of PI3K is recruited to phosphorylated tyrosine-801 of VEGFR2 (Dayanir et al. 2001).
Literature References
PubMed ID
Title
Journal
Year
10677529
Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells
Jiang, BH
,
Vogt, PK
,
Aoki, M
,
Zheng, JZ
Proc. Natl. Acad. Sci. U.S.A.
2000
Participants
Input
PI3K [cytosol]
(Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane]
(Homo sapiens)
Output
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K [plasma membrane]
(Homo sapiens)
Participates
as an event of
VEGFA-VEGFR2 Pathway (Homo sapiens)
Inferred From
P85-subuunit of PI3K binds p-6Y-VEGFR2 (Mus musculus)
Authored
Garapati, P V (2013-08-30)
Reviewed
Ballmer-Hofer, K (2014-05-12)
Welsh, M (2014-05-12)
Berger, P (2014-05-12)
Created
Garapati, P V (2013-12-19)
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