Reactome | p-Y420-FYN is phosphorylated on S21

p-Y420-FYN is phosphorylated on S21

Stable Identifier

R-HSA-5218854

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

FYN has multiple phosphorylation sites which can affect its kinase activity. Among these phosphorylation sites, serine 21 (S21) has been identified as a target site for protein kinase A (PKA). The phosphorylation of FYN S21 is critical for both FYN's tyrosine kinase activity and its focal adhesion targeting (Yeo et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
20658524	Phosphorylation of Ser 21 in Fyn regulates its kinase activity, focal adhesion targeting, and is required for cell migration Cho, HS, Marcantonio, EE, Yeo, MG, Song, WK, Chun, JS, Oh, HJ	J. Cell. Physiol.	2011