FYN has multiple phosphorylation sites which can affect its kinase activity. Among these phosphorylation sites, serine 21 (S21) has been identified as a target site for protein kinase A (PKA). The phosphorylation of FYN S21 is critical for both FYN's tyrosine kinase activity and its focal adhesion targeting (Yeo et al. 2007).
Cho, HS, Marcantonio, EE, Yeo, MG, Song, WK, Chun, JS, Oh, HJ
protein serine/threonine kinase activity of Protein kinase A catalytic subunit [cytosol]
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