Reactome | p-S166-RIPK1 [cytosol]

p-S166-RIPK1 [cytosol]

Stable Identifier

R-HSA-5218872

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

receptor interacting protein 1

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Locations in the PathwayBrowser

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Programmed Cell Death (Homo sapiens)

- Regulated Necrosis (Homo sapiens)
  - RIPK1-mediated regulated necrosis (Homo sapiens)
    - MLKL binds PIPs (Homo sapiens)
      - RIP1:RIP3:MLKL oligomer:PIPs [plasma membrane] (Homo sapiens)
        
        p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
        
        p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Homo sapiens)
        
        p-S166-RIPK1 [cytosol] (Homo sapiens)
      - p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
        
        p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Homo sapiens)
        
        p-S166-RIPK1 [cytosol] (Homo sapiens)
      - p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:FLOT1:FLOT2 [plasma membrane] (Homo sapiens)
        
        p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
        
        p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Homo sapiens)
        
        p-S166-RIPK1 [cytosol] (Homo sapiens)
      - p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:PDCD6IP:SDCBP [cytosol] (Homo sapiens)
        
        p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
        
        p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Homo sapiens)
        
        p-S166-RIPK1 [cytosol] (Homo sapiens)
    - MLKL oligomerizes (Homo sapiens)
      - (p-S-RIPK1:p-S199,227-RIPK3) oligomer:4x(MLKL:ATP) [cytosol] (Homo sapiens)
        
        p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Homo sapiens)
        
        p-S166-RIPK1 [cytosol] (Homo sapiens)
      - (p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Homo sapiens)
        
        p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Homo sapiens)
        
        p-S166-RIPK1 [cytosol] (Homo sapiens)
      - p-S-RIPK1:p-S199,227-RIPK3 oligomer:4xMLKL:IP6,IP5, IP4 [cytosol] (Homo sapiens)
        
        (p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Homo sapiens)
        
        p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Homo sapiens)
        
        p-S166-RIPK1 [cytosol] (Homo sapiens)
      - p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
        
        p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Homo sapiens)
        
        p-S166-RIPK1 [cytosol] (Homo sapiens)
    - Microbial modulation of RIPK1-mediated regulated necrosis (Homo sapiens)
      - SARS-CoV-1 3a binds RIPK1:RIPK3 oligomer (Homo sapiens)
        
        SARS-CoV-1 3a:(RIPK1:RIPK3) oligomer [cytosol] (Homo sapiens)
        
        p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Homo sapiens)
        
        p-S166-RIPK1 [cytosol] (Homo sapiens)
        
        p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Homo sapiens)
        
        p-S166-RIPK1 [cytosol] (Homo sapiens)
      - SARS-CoV-1 3a binds the lysosomal membrane (Homo sapiens)
        
        3a tetramer:(RIPK1:RIPK3) oligomer [cytosol] (Homo sapiens)
        
        p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Homo sapiens)
        
        p-S166-RIPK1 [cytosol] (Homo sapiens)
        
        3a tetramer:(RIPK1:RIPK3) oligomer [lysosomal membrane] (Homo sapiens)
        
        p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Homo sapiens)
        
        p-S166-RIPK1 [cytosol] (Homo sapiens)
      - SARS-CoV-1 3a oligomerizes (Homo sapiens)
        
        3a tetramer:(RIPK1:RIPK3) oligomer [cytosol] (Homo sapiens)
        
        p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Homo sapiens)
        
        p-S166-RIPK1 [cytosol] (Homo sapiens)
        
        SARS-CoV-1 3a:(RIPK1:RIPK3) oligomer [cytosol] (Homo sapiens)
        
        p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Homo sapiens)
        
        p-S166-RIPK1 [cytosol] (Homo sapiens)
    - RIPK1 is phosphorylated (Homo sapiens)
      - p-S-RIPK1:RIPK3 [cytosol] (Homo sapiens)
        
        p-S166-RIPK1 [cytosol] (Homo sapiens)
    - RIPK1:RIPK3 oligomer binds MLKL (Homo sapiens)
      - (RIPK1:RIPK3)oligomer:4xMLKL [cytosol] (Homo sapiens)
        
        p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Homo sapiens)
        
        p-S166-RIPK1 [cytosol] (Homo sapiens)
      - p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Homo sapiens)
        
        p-S166-RIPK1 [cytosol] (Homo sapiens)
    - RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Homo sapiens)
      - p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Homo sapiens)
        
        p-S166-RIPK1 [cytosol] (Homo sapiens)
      - p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Homo sapiens)
        
        p-S166-RIPK1 [cytosol] (Homo sapiens)
    - RIPK3 is phosphorylated (Homo sapiens)
      - p-S-RIPK1:RIPK3 [cytosol] (Homo sapiens)
        
        p-S166-RIPK1 [cytosol] (Homo sapiens)
      - p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Homo sapiens)
        
        p-S166-RIPK1 [cytosol] (Homo sapiens)
    - RIPK3 phosphorylates MLKL (Homo sapiens)
      - (RIPK1:RIPK3)oligomer:4xMLKL [cytosol] (Homo sapiens)
        
        p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Homo sapiens)
        
        p-S166-RIPK1 [cytosol] (Homo sapiens)
      - (p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Homo sapiens)
        
        p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Homo sapiens)
        
        p-S166-RIPK1 [cytosol] (Homo sapiens)
    - Regulation of necroptotic cell death (Homo sapiens)
      - ATP binds MLKL (Homo sapiens)
        
        (RIPK1:RIPK3)oligomer:4xMLKL [cytosol] (Homo sapiens)
        
        p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Homo sapiens)
        
        p-S166-RIPK1 [cytosol] (Homo sapiens)
        
        (p-S-RIPK1:p-S199,227-RIPK3) oligomer:4x(MLKL:ATP) [cytosol] (Homo sapiens)
        
        p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Homo sapiens)
        
        p-S166-RIPK1 [cytosol] (Homo sapiens)
      - MLKL binds FLOT1, FLOT2 (Homo sapiens)
        
        p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
        
        p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Homo sapiens)
        
        p-S166-RIPK1 [cytosol] (Homo sapiens)
        
        p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:FLOT1:FLOT2 [plasma membrane] (Homo sapiens)
        
        p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
        
        p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Homo sapiens)
        
        p-S166-RIPK1 [cytosol] (Homo sapiens)
      - MLKL binds IP4, IP5 and IP6 (Homo sapiens)
        
        (p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Homo sapiens)
        
        p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Homo sapiens)
        
        p-S166-RIPK1 [cytosol] (Homo sapiens)
        
        p-S-RIPK1:p-S199,227-RIPK3 oligomer:4xMLKL:IP6,IP5, IP4 [cytosol] (Homo sapiens)
        
        (p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Homo sapiens)
        
        p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Homo sapiens)
        
        p-S166-RIPK1 [cytosol] (Homo sapiens)
      - MLKL binds PDCD6IP and SDCBP (Homo sapiens)
        
        p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
        
        p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Homo sapiens)
        
        p-S166-RIPK1 [cytosol] (Homo sapiens)
        
        p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:PDCD6IP:SDCBP [cytosol] (Homo sapiens)
        
        p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)
        
        p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Homo sapiens)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Homo sapiens)
        
        p-S166-RIPK1 [cytosol] (Homo sapiens)
      - PELI1 binds activated RIPK1:RIPK3 (Homo sapiens)
        
        p-S-RIPK1:p-S199,227-RIPK3:PELI1 [cytosol] (Homo sapiens)
        
        p-S166-RIPK1 [cytosol] (Homo sapiens)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Homo sapiens)
        
        p-S166-RIPK1 [cytosol] (Homo sapiens)
      - PELI1 ubiquitinates RIPK3 at K363 (Homo sapiens)
        
        p-S-RIPK1:p-S199,227, K48pUb-363-RIPK3:PELI1 [cytosol] (Homo sapiens)
        
        p-S166-RIPK1 [cytosol] (Homo sapiens)
        
        p-S-RIPK1:p-S199,227-RIPK3:PELI1 [cytosol] (Homo sapiens)
        
        p-S166-RIPK1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13546 RIPK1

Gene Names

RIPK1, RIP, RIP1

Chain

chain:1-671

Reference Genes

BioGPS Gene:8737 RIPK1

COSMIC (genes):RIPK1 RIPK1

CTD Gene:8737 RIPK1

dbSNP Gene:8737 RIPK1

ENSEMBL:ENSG00000137275 RIPK1

HGNC:10019 RIPK1

KEGG Gene (Homo sapiens):8737 RIPK1

Monarch:8737 RIPK1

NCBI Gene:8737 RIPK1

OMIM:603453 RIPK1

UCSC:Q13546 RIPK1

Reference Transcript

Other Identifiers

0006520154

11737938_a_at

11737939_a_at

11737940_s_at

11750849_a_at

11756807_a_at

17004295

209941_at

226551_at

2892343

2892344

2892345

2892349

2892350

2892352

2892355

2892356

2892357

2892358

2892359

2892363

2892364

2892372

2892373

2892375

2892376

2892377

2892378

2892379

2892383

2892385

2892386

2892387

2892388

2892389

2939062

2939063

40696_at

475_at

51161_at

8116622

8737

A_23_P370005

A_33_P3279059

GO:0000166

GO:0001934

GO:0002376

GO:0002756

GO:0003674

GO:0004672

GO:0004674

GO:0004706

GO:0005123

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005737

GO:0005739

GO:0005768

GO:0005829

GO:0005886

GO:0006464

GO:0006468

GO:0006810

GO:0006915

GO:0006919

GO:0006950

GO:0006954

GO:0007165

GO:0007249

GO:0007256

GO:0007257

GO:0008150

GO:0008219

GO:0009056

GO:0009058

GO:0010008

GO:0010803

GO:0010940

GO:0010942

GO:0012501

GO:0016020

GO:0016032

GO:0016301

GO:0016310

GO:0016579

GO:0016740

GO:0019054

GO:0019899

GO:0022607

GO:0030154

GO:0031264

GO:0031410

GO:0031625

GO:0032757

GO:0032760

GO:0032991

GO:0033209

GO:0034138

GO:0034612

GO:0034641

GO:0035666

GO:0036289

GO:0042802

GO:0042803

GO:0043065

GO:0043066

GO:0043068

GO:0043123

GO:0043124

GO:0043167

GO:0043226

GO:0043235

GO:0044257

GO:0044403

GO:0044877

GO:0045121

GO:0045651

GO:0045944

GO:0046330

GO:0046777

GO:0048856

GO:0050729

GO:0051092

GO:0055085

GO:0060544

GO:0060545

GO:0060546

GO:0062099

GO:0065003

GO:0070105

GO:0070231

GO:0070266

GO:0070301

GO:0070513

GO:0070926

GO:0071356

GO:0071550

GO:0097190

GO:0097191

GO:0097300

GO:0097342

GO:0097343

GO:0097527

GO:0106310

GO:0106311

GO:1902041

GO:1902042

GO:1903800

GO:1905206

GO:1990000

GO:2000379

GO:2001237

GO:2001238

HMNXSV003025407

HMNXSV003028067

Hs.77273.1.A1_3p_at

Hs.77273.1.A1_3p_x_at

ILMN_1657937

ILMN_2119535

PH_hs_0018906

TC06000023.hg

TC06002463.hg

U50062_at

g3426026_3p_at

Participates

as a component of

Other forms of this molecule

K48polyUb-RIPK1 [cytosol]

PolyUb-RIPK1 [cytosol]

RIPK1 D324N [cytosol]

RIPK1 D324Y [cytosol]

RIPK1 D324V [cytosol]

RIPK1 D324H [cytosol]

RIPK1 [plasma membrane]

RIPK1(1-324) [cytosol]

RIPK1(325-671) [cytosol]

K63polyUb-RIPK1 [cytosol]

RIPK1 [endosome membrane]

RIPK1 [cytosol]

Inferred To

phospho-arkA [cytosol] (Dictyostelium discoideum)

phospho-ripk1l [cytosol] (Danio rerio)

phospho-RIPK1 [cytosol] (Bos taurus)

phospho-RIPK1 [cytosol] (Canis familiaris)

phospho-RIPK1 [cytosol] (Sus scrofa)

phospho-drkD [cytosol] (Dictyostelium discoideum)

phospho-p-S166-RIPK1 [cytosol] (Dictyostelium discoideum)

phospho-Ripk1 [cytosol] (Mus musculus)

phospho-Ripk1 [cytosol] (Rattus norvegicus)

Homologues of p-S166-RIPK1 [cytosol] (Dictyostelium discoideum)

phospho-ripk1 [cytosol] (Xenopus tropicalis)

Modified Residues

Name

O-phospho-L-serine at 166

Coordinate

166

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_003795.2, XP_005249514.2

ZINC - World Drugs

RIPK1_HUMAN

Guide to Pharmacology - Targets

2189

OpenTargets

ENSG00000137275

ZINC - FDA approved

RIPK1_HUMAN

ZINC - Substances

RIPK1_HUMAN

ZINC target

Q13546

PRO

Q13546

GlyGen

Q13546

PDB

6NYH, 4ITH, 6RLN, 5TX5, 5V7Z, 5HX6, 6HHO, 6C3E, 6R5F, 6C4D, 4ITJ, 6AC5, 7CJB, 6NW2, 4ITI, 6OCQ, 4NEU

ZINC - Investigational

RIPK1_HUMAN

HPA

ENSG00000137275-RIPK1

GeneCards

Q13546

Ensembl

ENSG00000137275, ENST00000380409, ENSP00000259808, ENSP00000369773, ENST00000259808

Pharos - Targets

Q13546

ZINC - Predictions - Purchasable

RIPK1_HUMAN

HMDB Protein

HMDBP09499

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14790 CASP8	8	CASP8(1-374) [cytosol] (R-HSA-3465404) CASP8(217-374) [mitochondrial outer membrane] (R-HSA-351869) CASP8(385-479) [mitochondrial outer membrane] (R-HSA-351828) CASP8(385-479) [cytosol] (R-HSA-76158) CASP8(375-384) [cytosol] (R-HSA-933460) CASP8(217-374) [cytosol] (R-HSA-75975) CASP8(1-216) [cytosol] (R-HSA-933456) CASP8(1-479) [cytosol] (R-HSA-57031)	0.959	30
UniProt:Q9Y572 RIPK3	7	p-S199,227, K48pUb-363-RIPK3 [cytosol] (R-HSA-9686933) OGlcNAc-T467-RIPK3 [cytosol] (R-HSA-9687819) RIPK3 [cytosol] (R-HSA-450328) p-S199,227-RIPK3 [cytosol] (R-HSA-5218873) Ub-K55,363-RIPK3 [cytosol] (R-HSA-9688825) RIPK3(1-328) [cytosol] (R-HSA-9686917) RIPK3(329-518) [cytosol] (R-HSA-9686937)	0.949	26
UniProt:Q13158 FADD	1	FADD [cytosol] (R-HSA-54639)	0.899	11
UniProt:Q9Y6K9 IKBKG	12	monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG [nucleoplasm] (R-HSA-4755413) IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG 420Wro447 [cytosol] (R-HSA-5262978) K63polyUb-NEMO [cytosol] (R-HSA-202530) Ub-285-IKBKG [cytosol] (R-HSA-741397) IKBKG [cytosol] (R-HSA-168108)	0.893	9
UniProt:Q13546 RIPK1	13	K48polyUb-RIPK1 [cytosol] (R-HSA-6783308) PolyUb-RIPK1 [cytosol] (R-HSA-6783197) RIPK1 D324N [cytosol] (R-HSA-9693930) RIPK1 D324Y [cytosol] (R-HSA-9693931) RIPK1 D324V [cytosol] (R-HSA-9693927) RIPK1 D324H [cytosol] (R-HSA-9693922) RIPK1 [plasma membrane] (R-HSA-937073) RIPK1(1-324) [cytosol] (R-HSA-5212664) RIPK1(325-671) [cytosol] (R-HSA-5212671) p-S166-RIPK1 [cytosol] (R-HSA-5218872) K63polyUb-RIPK1 [cytosol] (R-HSA-937021) RIPK1 [endosome membrane] (R-HSA-450326) RIPK1 [cytosol] (R-HSA-168651)	0.892	11
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.884	10
UniProt:P19438 TNFRSF1A	2	TNFRSF1A(30-45) [plasma membrane] (R-HSA-5675738) TNFRSF1A(41-201) [extracellular region] (R-HSA-6785048)	0.839	6
UniProt:P01375 TNF	5	TNF(52-76) [extracellular region] (R-HSA-8863375) TNF(1-34) [plasma membrane] (R-HSA-8863367) TNF(1-76) [plasma membrane] (R-HSA-8863120) TNF(77-233) [extracellular region] (R-HSA-976821) TNF(1-233) [plasma membrane] (R-HSA-66220)	0.837	9
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.798	8
UniProt:P0DTD1-PRO_0000449629 REP			0.723	5
UniProt:Q13114 TRAF3	4	TRAF3 R118W [cytosol] (R-HSA-5602321) K48polyUb-TRAF3 [cytosol] (R-HSA-936556) TRAF3 [cytosol] (R-HSA-914241) K63polyUb-TRAF3 [cytosol] (R-HSA-936402)	0.703	5
UniProt:Q13490 BIRC2	5	K63polyUb-BIRC2 [cytosol] (R-HSA-5668512) BIRC2(1-372) [cytosol] (R-HSA-202913) BIRC2(373-618) [cytosol] (R-HSA-202931) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2 [cytosol] (R-HSA-50847)	0.697	5
UniProt:Q13489 BIRC3	3	BIRC3 [cytosol] (R-HSA-50845) K48pUb-BIRC3 [cytosol] (R-HSA-5675478) K63polyUb-BIRC3 [cytosol] (R-HSA-5668478)	0.602	3
UniProt:P48729 CSNK1A1	2	CSNK1A1 [cytosol] (R-HSA-195263) CSNK1A1 [cilium] (R-HSA-5632507)	0.602	5
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.589	2
UniProt:Q15628 TRADD	1	TRADD [cytosol] (R-HSA-66376)	0.564	3
UniProt:P04083 ANXA1	2	ANXA1 [cytosol] (R-HSA-5263630) ANXA1 [extracellular region] (R-HSA-444539)	0.556	5
IntAct:EBI-4399559 UBIQ			0.544	3
UniProt:Q8IVM0 CCD50			0.524	2
UniProt:Q13107 USP4	1	USP4 [cytosol] (R-HSA-5212663)	0.524	4
UniProt:O00635 TRIM38	1	TRIM38 [cytosol] (R-HSA-5624325)	0.508	2
UniProt:B7UI21 NLEB1			0.508	4
UniProt:U5TQE9 U5TQE9			0.499	3

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