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MLKL [cytosol]
Stable Identifier
R-HSA-5218901
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Icon
Locations in the PathwayBrowser for interactor ChEBI:63770%20NECROSULFONAMIDE
Expand all
Disease (Homo sapiens)
Diseases of programmed cell death (Homo sapiens)
Defective RIPK1-mediated regulated necrosis (Homo sapiens)
Microbial modulation of RIPK1-mediated regulated necrosis (Homo sapiens)
HCMV UL36 binds MLKL (Homo sapiens)
MLKL [cytosol] (Homo sapiens)
IAV NS1 binds MLKL (Homo sapiens)
MLKL [cytosol] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Regulated Necrosis (Homo sapiens)
RIPK1-mediated regulated necrosis (Homo sapiens)
RIPK1:RIPK3 oligomer binds MLKL (Homo sapiens)
MLKL [cytosol] (Homo sapiens)
Regulation of necroptotic cell death (Homo sapiens)
MLKL binds HSP90:CDC37 (Homo sapiens)
MLKL [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8NB16 MLKL
Gene Names
MLKL
Chain
chain:1-471
Reference Genes
BioGPS Gene:197259 MLKL
COSMIC (genes):MLKL MLKL
CTD Gene:197259 MLKL
dbSNP Gene:197259 MLKL
ENSEMBL:ENSG00000168404 MLKL
ENSEMBL_homo_sapiens_GENE:ENSG00000168404.13 MLKL
HGNC:26617 MLKL
KEGG Gene (Homo sapiens):197259 MLKL
Monarch:197259 MLKL
NCBI Gene:197259 MLKL
OMIM:615153 MLKL
UCSC:Q8NB16 MLKL
Reference Transcript
RefSeq:NM_001142497.2 MLKL
RefSeq:XM_005255834.3 MLKL
RefSeq:NM_152649.3 MLKL
Other Identifiers
11754630_a_at
16828344
197259
238025_PM_at
238025_at
3699083
3699086
3699087
3699090
3699091
3699093
3699104
3699105
3699107
3699108
3699110
3699111
3699114
3699119
3699120
3699121
3699125
3699126
3699127
3699128
3699129
50829_at
8002778
A_23_P61050
A_24_P185044
GE87884
GO:0000166
GO:0003824
GO:0004672
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0006468
GO:0007166
GO:0012501
GO:0016020
GO:0016740
GO:0019901
GO:0023052
GO:0030054
GO:0036211
GO:0042802
GO:0043226
GO:0044877
GO:0051607
GO:0065003
GO:0070207
GO:0070266
GO:0097527
GO:0097528
GO:0098542
GO:0140096
HMNXSV003013902
HMNXSV003026069
Hs.119878.0.A1_3p_at
ILMN_1667825
ILMN_1715863
ILMN_1737498
TC16001270.hg
Participates
as a component of
MLKL:UL36 [cytosol] (Homo sapiens)
MLKL:HSP90:CDC37 [cytosol] (Homo sapiens)
MLKL:ATP [cytosol] (Homo sapiens)
NS1:MLKL [cytosol] (Homo sapiens)
(RIPK1:RIPK3)oligomer:4xMLKL [cytosol] (Homo sapiens)
as an input of
HCMV UL36 binds MLKL (Homo sapiens)
IAV NS1 binds MLKL (Homo sapiens)
MLKL binds HSP90:CDC37 (Homo sapiens)
RIPK1:RIPK3 oligomer binds MLKL (Homo sapiens)
Other forms of this molecule
K63PolyUb-K50,p-T357,S358-MLKL [cytosol]
p-T357,S358-MLKL [cytosol]
Inferred To
MLKL [cytosol]
(Bos taurus)
MLKL [cytosol]
(Dictyostelium discoideum)
MLKL [cytosol]
(Gallus gallus)
MLKL [cytosol]
(Mus musculus)
MLKL [cytosol]
(Sus scrofa)
mlkl [cytosol]
(Xenopus tropicalis)
Mlkl [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
XP_005255891.1
,
NP_689862.1
,
NP_001135969.1
Guide to Pharmacology - Targets
2106
OpenTargets
ENSG00000168404
GeneCards
Q8NB16
HPA
ENSG00000168404-MLKL
Ensembl
ENST00000308807
,
ENSP00000308351
,
ENSP00000303118
,
ENST00000306247
,
ENSG00000168404
PRO
Q8NB16
Pharos - Targets
Q8NB16
HMDB Protein
HMDBP09462
PDB
5KO1
,
6D74
,
6ZLE
,
7NM5
,
7JXU
,
6ZZ1
,
7NM4
,
7JW7
,
6O5Z
,
6LK5
,
6LK6
,
5KNJ
,
6ZVO
,
7NM2
,
6ZPR
,
4MWI
,
6UX8
,
7MON
,
4M67
,
2MSV
,
6BWK
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y572 RIPK3
8
p-S199,227, K48pUb-363-RIPK3 [cytosol]
(R-HSA-9686933)
K33polyUb-K197,302,364-RIPK3 [cytosol]
(R-HSA-9794180)
OGlcNAc-T467-RIPK3 [cytosol]
(R-HSA-9687819)
RIPK3(329-518) [cytosol]
(R-HSA-9686937)
RIPK3 [cytosol]
(R-HSA-450328)
p-S199,227-RIPK3 [cytosol]
(R-HSA-5218873)
Ub-K55,363-RIPK3 [cytosol]
(R-HSA-9688825)
RIPK3(1-328) [cytosol]
(R-HSA-9686917)
0.641
10
ChEBI:63770 NECROSULFONAMIDE
0.591
4
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