Reactome | TET2 [nucleoplasm]

TET2 [nucleoplasm]

Stable Identifier

R-HSA-5221011

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Methylcytosine dioxygenase TET2 ecNumber1.14.11.n2/ecNumber, TET2_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:O15294 OGT

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External Reference Information

External Reference

UniProt:Q6N021 TET2

Gene Names

TET2, KIAA1546, Nbla00191

Chain

chain:1-2002

Reference Genes

BioGPS Gene:54790 TET2

COSMIC (genes):TET2 TET2

CTD Gene:54790 TET2

dbSNP Gene:54790 TET2

ENSEMBL:ENSG00000168769 TET2

HGNC:25941 TET2

KEGG:hsa:54790 TET2

Monarch:54790 TET2

NCBI Gene:54790 TET2

OMIM:612839 TET2

UCSC:Q6N021 TET2

Reference Transcript

Participates

as an output of

Expression of TET2 in primordial germ cells (Homo sapiens)

as a component of

TET2:Fe2+ [nucleoplasm] (Homo sapiens)

Cross References

OpenTargets

ENSG00000168769

ENSEMBL

ENST00000305737, ENST00000265149, ENSP00000265149, ENSP00000369351, ENSP00000442788, ENSP00000306705, ENST00000540549, ENST00000380013, ENSG00000168769

IntEnz

1.14.11.80

HPA

ENSG00000168769-TET2

GeneCards

TET2

PRO

Q6N021

Pharos - Targets

Q6N021

Orphanet

TET2

GlyGen

Q6N021

PDB

7NE3, 7NE6, 4NM6, 5D9Y, 5DEU

HMDB Protein

HMDBP11973

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.68	4
UniProt:O15294 OGT	2	OGT [cytosol] (R-HSA-9687814) OGT [nucleoplasm] (R-HSA-3321845)	0.659	7
UniProt:Q15233 NONO			0.615	4
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.615	3
UniProt:P19544 WT1	1	WT1 [nucleoplasm] (R-HSA-452420)	0.602	9
UniProt:P04279 SEMG1	2	SEMG1 [extracellular region] (R-HSA-977100) hC239-SEMG1 [extracellular region] (R-HSA-6810688)	0.589	2
UniProt:P06396 GSN	7	GSN [cytosol] (R-HSA-350275) GSN(28-403) [cytosol] (R-HSA-201618) GSN(404-782) [cytosol] (R-HSA-350272) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN [extracellular region] (R-HSA-6806510) GSN [secretory granule lumen] (R-HSA-6801486) GSN(200-270) [extracellular region] (R-HSA-976940)	0.556	3
UniProt:P22607 FGFR3	20	FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 805fs*141 [plasma membrane] (R-HSA-1614387) p-6Y-FGFR3 A391E [plasma membrane] (R-HSA-2065835) p-6Y-FGFR3 K650T [plasma membrane] (R-HSA-2032966) p-6Y-FGFR3 G382D [plasma membrane] (R-HSA-2032950) p-6Y-FGFR3 G380R [plasma membrane] (R-HSA-2032946) p-6Y-FGFR3 K650M [plasma membrane] (R-HSA-2032959)	0.556	3
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.483	2
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.483	2

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