Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
BCL6 [nucleoplasm]
Stable Identifier
R-HSA-5223066
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
B-cell lymphoma 6 protein, BCL6_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
FOXO-mediated transcription (Homo sapiens)
FOXO-mediated transcription of cell death genes (Homo sapiens)
BCL6 gene expression is stimulated by FOXO3,FOXO4,(FOXO1) (Homo sapiens)
BCL6 [nucleoplasm] (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Homo sapiens)
TP53 stimulates BCL6 expression (Homo sapiens)
BCL6 [nucleoplasm] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
Expression of STAT3-upregulated nuclear proteins (Homo sapiens)
STAT3-upregulated nuclear proteins [nucleoplasm] (Homo sapiens)
BCL6 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P41182 BCL6
Gene Names
BCL6, BCL5, LAZ3, ZBTB27, ZNF51
Chain
chain:1-706
Reference Genes
BioGPS Gene:604 BCL6
COSMIC (genes):BCL6 BCL6
CTD Gene:604 BCL6
dbSNP Gene:604 BCL6
ENSEMBL:ENSG00000113916 BCL6
HGNC:1001 BCL6
KEGG:hsa:604 BCL6
Monarch:604 BCL6
NCBI Gene:604 BCL6
OMIM:109565 BCL6
UCSC:P41182 BCL6
Reference Transcript
RefSeq:NM_001706.4 BCL6
RefSeq:NM_001134738.1 BCL6
RefSeq:XM_005247694.3 BCL6
RefSeq:NM_001130845.1 BCL6
RefSeq:XM_011513062.2 BCL6
Other Identifiers
11720745_a_at
11720746_s_at
11739841_a_at
11750749_a_at
11759322_at
16962584
203140_PM_at
203140_at
215990_PM_s_at
215990_s_at
228758_PM_at
228758_at
2709777
2709779
2709780
2709781
2709782
2709783
2709784
2709785
2709787
2709788
2709789
2709790
2709792
2709793
2709795
2709798
2709799
2709801
2709802
2709804
2709805
2709806
2709807
2709808
2709809
2709810
2709811
2709818
2709819
40091_at
46584_at
604
8092691
86652_at
978_at
979_g_at
A_23_P57856
GE61240
GO:0000122
GO:0000902
GO:0000977
GO:0000978
GO:0001161
GO:0001222
GO:0001227
GO:0001817
GO:0001953
GO:0002317
GO:0002376
GO:0002467
GO:0002634
GO:0002682
GO:0002829
GO:0002903
GO:0003677
GO:0003682
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005657
GO:0005730
GO:0005794
GO:0006310
GO:0006325
GO:0006351
GO:0006355
GO:0006357
GO:0006366
GO:0006954
GO:0006974
GO:0007010
GO:0007155
GO:0007160
GO:0007266
GO:0007283
GO:0008104
GO:0008283
GO:0021859
GO:0022414
GO:0030036
GO:0030154
GO:0030183
GO:0030308
GO:0030890
GO:0031490
GO:0031507
GO:0032764
GO:0032943
GO:0032945
GO:0035024
GO:0042092
GO:0042100
GO:0042127
GO:0042129
GO:0042382
GO:0042802
GO:0043065
GO:0043066
GO:0043226
GO:0043380
GO:0043565
GO:0045064
GO:0045591
GO:0045595
GO:0045629
GO:0045666
GO:0045746
GO:0045892
GO:0046872
GO:0048289
GO:0048294
GO:0048821
GO:0048856
GO:0048870
GO:0050727
GO:0050776
GO:0140110
GO:0140297
GO:1900099
GO:1903464
GO:1990837
GO:2000147
GO:2000773
HMNXSV003007979
Hs.155024.1.S1_3p_a_at
Hs.63920.0.A1_3p_at
ILMN_1737314
ILMN_1746053
PH_hs_0009331
TC03002096.hg
U00115_at
Z79581_at
g4502382_3p_at
Participates
as a member of
STAT3-upregulated nuclear proteins [nucleoplasm] (Homo sapiens)
as an output of
BCL6 gene expression is stimulated by FOXO3,FOXO4,(FOXO1) (Homo sapiens)
TP53 stimulates BCL6 expression (Homo sapiens)
Cross References
RefSeq
NP_001124317.1
,
XP_005247751.1
,
NP_001697.2
,
NP_001128210.1
,
XP_011511364.1
Guide to Pharmacology - Targets
2957
OpenTargets
ENSG00000113916
ENSEMBL
ENST00000621333
,
ENSP00000384371
,
ENST00000232014
,
ENSP00000413122
,
ENSP00000232014
,
ENSP00000479784
,
ENST00000450123
,
ENST00000406870
HPA
ENSG00000113916-BCL6
PRO
P41182
Pharos - Targets
P41182
Orphanet
BCL6
PDB
6TOM
,
7LZS
,
6C3L
,
7T0T
,
6TOL
,
7LWG
,
6TOF
,
5N21
,
7ZWU
,
7OKE
,
4CP3
,
7OKK
,
8C78
,
2EN2
,
2YRM
,
7OKJ
,
6XYX
,
5MW6
,
6EW7
,
5X4Q
,
7Q7V
,
3BIM
,
7RV4
,
6TBT
,
1R2B
,
7RV7
,
1R28
,
5X4O
,
7ZWO
,
6TCJ
,
7ZWQ
,
7LZQ
,
6TOH
,
6C3N
,
3LBZ
,
5H7H
,
5H7G
,
5X9P
,
5X4N
,
6TOO
,
7OKL
,
7ZWV
,
7OKG
,
7OKF
,
7ZWZ
,
4U2M
,
7LWE
,
5N20
,
5X9O
,
7RV1
,
7RUX
,
7Q7R
,
6XZZ
,
6EW6
,
6Y17
,
7RUW
,
7ZWR
,
7RV5
,
5MW2
,
6ZBU
,
6TOK
,
5X4M
,
3E4U
,
7LZR
,
6XMX
,
7ZWW
,
7OKD
,
6TOJ
,
7RUZ
,
6XWF
,
7QK0
,
5MWD
,
6XXS
,
7OKH
,
7ZWX
,
7RV6
,
7Q7S
,
1R29
,
7RV8
,
7RV9
,
7RV2
,
5N1X
,
7ZWS
,
2EOS
,
6TON
,
6TOG
,
7T0S
,
6CQ1
,
2LCE
,
8AS9
,
7ZWT
,
7OKI
,
7OKM
,
7T0U
,
6TOI
,
7LWF
,
7ZWY
,
7Q7T
,
7Q7U
,
7BDE
,
7RUY
,
7RV0
,
7ZWP
,
7ZWN
,
5X4P
,
7RV3
,
6EW8
,
5N1Z
Interactors (53)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P0CW20 LIMS4
0.718
6
UniProt:Q13077 TRAF1
3
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.696
5
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.696
5
UniProt:Q9H2G9 BLZF1
1
BLZF1 [Golgi membrane]
(R-HSA-2422372)
0.675
4
UniProt:P41182 BCL6
1
BCL6 [nucleoplasm]
(R-HSA-5223066)
0.666
4
UniProt:Q96RU7 TRIB3
3
TRIB3 [plasma membrane]
(R-HSA-199447)
TRIB3 [cytosol]
(R-HSA-162411)
TRIB3 [nucleoplasm]
(R-HSA-9635877)
0.666
4
UniProt:Q86XK2 FBXO11
1
FBXO11 [cytosol]
(R-HSA-8955092)
0.653
9
UniProt:Q9UKV0 HDAC9
1
HDAC9 [nucleoplasm]
(R-HSA-3004554)
0.564
2
UniProt:Q12933 TRAF2
5
TRAF2 [cytosol]
(R-HSA-66370)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
TRAF2 [nucleoplasm]
(R-HSA-8862199)
0.556
3
UniProt:Q8IUQ4 SIAH1
1
SIAH1 [cytosol]
(R-HSA-374563)
0.556
3
IntAct:EBI-16435576 CCSB ORF ID
0.556
3
UniProt:O15156 ZBT7B
0.556
3
UniProt:Q9Y6H3 ATP23
0.556
3
UniProt:Q9BRX9 WDR83
1
WDR83 [endosome membrane]
(R-HSA-5672942)
0.556
3
UniProt:Q04864-2 REL
0.556
3
UniProt:Q8NCR6 SMIP6
0.556
3
UniProt:A8KA13 A8KA13
0.556
3
UniProt:Q9BVG8 KIFC3
0.556
3
UniProt:Q8WW24 TEKT4
0.556
3
UniProt:Q9NZN8 CNOT2
1
CNOT2 [cytosol]
(R-HSA-429902)
0.556
3
UniProt:Q96B67 ARRD3
0.556
3
UniProt:Q8N9V6-2 ANKRD53
0.556
3
UniProt:Q9BYU1 PBX4
0.556
3
UniProt:B2RV13 CF97D
0.556
3
UniProt:Q52LG2 KRTAP13-2
1
KRTAP13-2 [cytosol]
(R-HSA-6810274)
0.556
3
UniProt:Q8N865 SMIP4
0.556
3
UniProt:Q08117 TLE5
1
AES [nucleoplasm]
(R-HSA-4648963)
0.556
3
UniProt:Q8IUB9 KRTAP19-1
1
KRTAP19-1 [cytosol]
(R-HSA-6810285)
0.556
3
UniProt:Q9BS75 Q9BS75
0.556
3
UniProt:Q96LM5 SMIP2
0.556
3
UniProt:Q6P656 CF161
0.556
3
UniProt:Q8NI37 PPTC7
0.556
3
UniProt:Q12888 TP53BP1
3
TP53BP1 [nucleoplasm]
(R-HSA-61175)
p-S25,S1778-TP53BP1 [nucleoplasm]
(R-HSA-5683418)
monoSUMO1-K-TP53BP1 [nucleoplasm]
(R-HSA-2997591)
0.556
3
UniProt:O43257 ZNHI1
0.556
3
UniProt:Q99471 PFDN5
1
PFDN5 [cytosol]
(R-HSA-379548)
0.556
3
UniProt:Q53G59 KLHL12
1
KLHL12 [cytosol]
(R-HSA-1504203)
0.556
3
UniProt:Q8WVV4-1 POF1B
0.556
3
UniProt:Q9NTM9 CUTC
1
CUTC [cytosol]
(R-HSA-5216017)
0.556
3
UniProt:P28070 PSMB4
4
PSMB4 [cytosol]
(R-HSA-68750)
PSMB4 [nucleoplasm]
(R-HSA-174343)
pro-PSMB4 [cytosol]
(R-HSA-9908138)
PSMB4(1-45) [cytosol]
(R-HSA-9908122)
0.556
3
UniProt:Q13616 CUL1
3
CUL1 [cytosol]
(R-HSA-174230)
CUL1 [nucleoplasm]
(R-HSA-187551)
G76-NEDD8-K720-CUL1 [cytosol]
(R-HSA-8952519)
0.527
2
UniProt:P56524 HDAC4
3
polySUMO2,3-K559-HDAC4 [nucleoplasm]
(R-HSA-4616029)
monoSUMO1-K559-HDAC4 [nucleoplasm]
(R-HSA-4616016)
HDAC4 [nucleoplasm]
(R-HSA-351581)
0.499
3
UniProt:Q9ULU4 ZMYD8
0.499
3
UniProt:P15976-2 GATA1
0.488
2
UniProt:Q99750 MDFI
0.488
2
UniProt:Q8IYA8 IHO1
0.488
2
UniProt:Q5JR59-3 MTUS2
0.488
2
UniProt:O43307 ARHGEF9
1
ARHGEF9 [cytosol]
(R-HSA-195067)
0.488
2
UniProt:Q08117-2 TLE5
0.488
2
UniProt:O76003 GLRX3
1
GLRX3 [cytosol]
(R-HSA-5691202)
0.488
2
UniProt:Q9UBB9 TFIP11
1
TFIP11 [nucleoplasm]
(R-HSA-8869310)
0.488
2
IntAct:EBI-11742485 SSX2IP
0.488
2
UniProt:O14641 DVL2
5
DVL2 [cytosol]
(R-HSA-201694)
pp-DVL2 [cytosol]
(R-HSA-3772398)
p-DVL2 [cytosol]
(R-HSA-201706)
p-DVL2 [clathrin-coated endocytic vesicle]
(R-HSA-5138444)
ub-DVL2 [cytosol]
(R-HSA-4652689)
0.488
2
UniProt:P57796-2 CABP4
0.488
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text