Reactome | ABCE1 binds RNASEL, inhibiting it

ABCE1 binds RNASEL, inhibiting it

Stable Identifier

R-HSA-5223305

Type

Reaction [binding]

Species

Homo sapiens

Compartment

mitochondrial matrix

ReviewStatus

5/5

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2-5A-dependent ribonuclease (RNASEL) is an endoribonuclease that is activated in the interferon (IFN) antiviral response. Its anti-viral effects are probably a combination of induction of apoptosis, cleavage of viral mRNA and induction of other anti-viral genes. ATP-binding cassette sub-family E member 1 (ABCE1, aka RNase L inhibitor, RLI) directly interacts with RNASEL and inhibits its endoribonuclease activity, thus antagonising the anti-viral effect of the IFN-regulated 2-5A/RNase L pathway (Martinand et al. 1998, Martinand et al. 1999, Le Roy et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
9660177	RNase L inhibitor (RLI) antisense constructions block partially the down regulation of the 2-5A/RNase L pathway in encephalomyocarditis-virus-(EMCV)-infected cells Martinand, C, Salehzada, T, Silhol, M, Lebleu, B, Bisbal, C	Eur. J. Biochem.	1998
11585831	The 2-5A/RNase L/RNase L inhibitor (RLI) [correction of (RNI)] pathway regulates mitochondrial mRNAs stability in interferon alpha-treated H9 cells Le Roy, F, Bisbal, C, Silhol, M, Martinand, C, Lebleu, B, Salehzada, T	J. Biol. Chem.	2001
9847332	RNase L inhibitor is induced during human immunodeficiency virus type 1 infection and down regulates the 2-5A/RNase L pathway in human T cells Martinand, C, Montavon, C, Salehzada, T, Silhol, M, Lebleu, B, Bisbal, C	J. Virol.	1999