Reactome | PRMT6 [nucleoplasm]

PRMT6 [nucleoplasm]

Stable Identifier

R-HSA-5226884

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Protein arginine N-methyltransferase 6 ecNumber2.1.1.-/ecNumber, ANM6_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q96BD6 SPSB1

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX1 (Homo sapiens)
      - RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Homo sapiens)
        
        RUNX1 binds SIN3A,(SIN3B) co-repressor (Homo sapiens)
        
        PRMT6 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96LA8 PRMT6

Gene Names

PRMT6, HRMT1L6

Chain

chain:1-375

Reference Genes

BioGPS Gene:55170 PRMT6

COSMIC (genes):PRMT6 PRMT6

CTD Gene:55170 PRMT6

dbSNP Gene:55170 PRMT6

ENSEMBL:ENSG00000198890 PRMT6

ENSEMBL_homo_sapiens_GENE:ENSG00000198890.9 PRMT6

HGNC:18241 PRMT6

KEGG Gene (Homo sapiens):55170 PRMT6

Monarch:55170 PRMT6

NCBI Gene:55170 PRMT6

OMIM:608274 PRMT6

UCSC:Q96LA8 PRMT6

Reference Transcript

RefSeq:NM_018137.2 PRMT6

Other Identifiers

11725345_at

11751039_a_at

11751481_a_at

16667918

223275_PM_at

223275_at

2349849

2349850

2349851

2349852

2349853

2349854

55170

64062_at

7903457

A_14_P123271

A_23_P12336

GE55783

GO:0000122

GO:0002376

GO:0003682

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0006281

GO:0006284

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0006974

GO:0007005

GO:0008168

GO:0008469

GO:0010821

GO:0016274

GO:0016740

GO:0018216

GO:0019919

GO:0023052

GO:0030154

GO:0030163

GO:0032259

GO:0035241

GO:0035242

GO:0036211

GO:0042054

GO:0042393

GO:0043226

GO:0044020

GO:0045652

GO:0045892

GO:0048856

GO:0070611

GO:0070612

GO:0090398

GO:0140096

GO:0140938

GO:1901796

GO:2000059

HMNXSV003002786

ILMN_1813834

ILMN_2234229

PH_hs_0002291

TC01000925.hg

g12803778_3p_at

Participates

as a member of

as an input of

RUNX1 binds SIN3A,(SIN3B) co-repressor (Homo sapiens)

as a component of

RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)

Inferred To

Ghost homologue of PRMT6 [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of PRMT6 [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of PRMT6 [nucleoplasm] (Gallus gallus)

Ghost homologue of PRMT6 [nucleoplasm] (Rattus norvegicus)

PRMT6 [nucleoplasm] (Bos taurus)

PRMT6 [nucleoplasm] (Canis familiaris)

PRMT6 [nucleoplasm] (Danio rerio)

PRMT6 [nucleoplasm] (Mus musculus)

PRMT6 [nucleoplasm] (Sus scrofa)

PRMT6 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_060607.2

Guide to Pharmacology - Targets

1257

OpenTargets

ENSG00000198890

GeneCards

Q96LA8

HPA

ENSG00000198890-PRMT6

Ensembl

ENSP00000359095, ENSG00000198890, ENST00000370078

ZINC target

Q96LA8

PRO

Q96LA8

Pharos - Targets

Q96LA8

HMDB Protein

HMDBP11616

PDB

4Y30, 6P7I, 5E8R, 6WAD, 7NR4, 5EGS, 4QPP, 4QQK, 4HC4, 4Y2H, 6W6D, 5WCF, 5HZM

Interactors (38)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96DV4 MRPL38	1	MRPL38 [mitochondrial inner membrane] (R-HSA-5368202)	0.659	3
UniProt:Q9UJU2 LEF1	2	LEF1 [nucleoplasm] (R-HSA-3214972) pT155,S166-LEF1 [nucleoplasm] (R-HSA-4411389)	0.641	3
UniProt:P17096-1 HMGA1			0.632	4
UniProt:A8K932 A8K932			0.556	3
UniProt:Q14011 CIRBP			0.527	3
UniProt:Q9UKB3 DJC12			0.527	2
UniProt:O60293 ZC3H1			0.527	2
UniProt:Q12905 ILF2	5	ILF2 [cytosol] (R-HSA-9836392) ILF2 [tertiary granule lumen] (R-HSA-6800995) ILF2 [extracellular region] (R-HSA-6799684) ILF2 [ficolin-1-rich granule lumen] (R-HSA-6801001) ILF2 [specific granule lumen] (R-HSA-6799611)	0.527	4
UniProt:Q9BQB4 SOST	1	SOST [extracellular region] (R-HSA-3769322)	0.527	3
UniProt:Q9BUQ8 DDX23	1	DDX23 [nucleoplasm] (R-HSA-71879)	0.527	2
UniProt:Q13522 PPR1A			0.527	2
ChEBI:15414 S-ADENOSYL-L-METHIONINE			0.524	6
UniProt:P52926 HMGA2	1	HMGA2 [nucleoplasm] (R-HSA-1629831)	0.524	2
UniProt:Q86SE9 PCGF5	1	PCGF5 [nucleoplasm] (R-HSA-8937962)	0.508	2
UniProt:Q96BD6 SPSB1	1	SPSB1 [cytosol] (R-HSA-976024)	0.508	2
UniProt:Q6P047 CH074			0.508	2
UniProt:Q9BQS8 FYCO1			0.508	2
UniProt:Q9Y2M5 KLHL20	1	KLHL20 [cytosol] (R-HSA-976032)	0.508	2
UniProt:Q9BX10 GTPBP2	2	GTPBP2 [extracellular region] (R-HSA-8863001) GTPBP2 [platelet alpha granule lumen] (R-HSA-8862960)	0.508	2
UniProt:Q96H20 SNF8	1	SNF8 [cytosol] (R-HSA-917711)	0.508	2
UniProt:Q9Y365 STARD10	2	p-S284-STARD10 [cytosol] (R-HSA-8873930) STARD10 [cytosol] (R-HSA-8873867)	0.508	2
UniProt:Q8NEC7 GSTCD			0.508	2
UniProt:P00973 OAS1	1	OAS1 [cytosol] (R-HSA-947486)	0.508	2
UniProt:Q96JB6 LOXL4	3	LOXL4(25-?) [extracellular region] (R-HSA-2022087) LOXL4 [extracellular region] (R-HSA-2022127) LOXL4(?-756) [extracellular region] (R-HSA-2022098)	0.508	2
UniProt:Q9BXL8 CDCA4			0.508	2
UniProt:Q96EY1 DNJA3			0.508	2
UniProt:P50749 RASF2			0.508	2
UniProt:Q9UBX0 HESX1			0.508	2
UniProt:Q9H204 MED28	1	MED28 [nucleoplasm] (R-HSA-6804546)	0.508	2
UniProt:Q9UGK8 SRGEF			0.508	2
UniProt:O15198 SMAD9	3	SMAD9 [cytosol] (R-HSA-201478) p-S465,S467-SMAD9 [nucleoplasm] (R-HSA-201474) p-S465,S467-SMAD9 [cytosol] (R-HSA-201441)	0.508	2
UniProt:Q8TE85 GRHL3			0.508	2
UniProt:O14645 IDLC			0.508	2
UniProt:Q8N1K5 THMS1			0.508	2
UniProt:Q14995 NR1D2	1	NR1D2 [nucleoplasm] (R-HSA-375501)	0.508	2
UniProt:O00231 PSMD11	5	PSMD11 [secretory granule lumen] (R-HSA-6800943) PSMD11 [extracellular region] (R-HSA-6806441) PSMD11 [ficolin-1-rich granule lumen] (R-HSA-6800436) PSMD11 [nucleoplasm] (R-HSA-174327) PSMD11 [cytosol] (R-HSA-68790)	0.508	2
UniProt:Q9Y3A6 TMED5	1	TMED5 [endoplasmic reticulum membrane] (R-HSA-3247761)	0.508	2
UniProt:Q9HAQ2 KIF9	1	KIF9 [cytosol] (R-HSA-984616)	0.508	2

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