AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it

Stable Identifier
R-HSA-5226904
Type
Reaction [binding]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, endoplasmic reticulum lumen
ReviewStatus
5/5
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AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it
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Putative adenosylhomocysteinase 2 (AHCYL1 aka adenosylhomocysteine hydrolase-like protein 1) (Dekker et al. 2002) possesses 50% homology to adenosylhomocysteine hydrolase (AHCY), an enzyme important for metabolizing S-adenosyl-l-homocysteine. AHCYL1 can bind to the inositol 1,4,5-trisphosphate receptor (ITPR1) tetramer, suggesting that AHCYL1 is involved in modulating intracellular calcium release (Cooper et al. 2006).
Literature References
PubMed ID Title Journal Year
11904675 Identification of an S-adenosylhomocysteine hydrolase-like transcript induced during dendritic cell differentiation

Cooper, BJ, Angel, NZ, Budhia, S, Hart, DN, Dekker, JW, Clark, GJ, Kato, M

Immunogenetics 2002
16754674 Suppression and overexpression of adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) influences zebrafish embryo development: a possible role for AHCYL1 in inositol phospholipid signaling

Cooper, BJ, Angel, NZ, Key, B, Hart, DN, Kato, M, Carter, A

J. Biol. Chem. 2006
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Orthologous Events
AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Bos taurus)
AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Canis familiaris)
AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Drosophila melanogaster)
AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Gallus gallus)
AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Mus musculus)
AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Rattus norvegicus)
AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Sus scrofa)
Authored
Jassal, B  (2014-01-09)
Reviewed
D'Eustachio, P  (2015-02-11)
Created
Jassal, B  (2014-01-09)
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