Transcytosis and dissociation of botA:NTNHA:HA

Stable Identifier
R-HSA-5228943
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Clostridium botulinum
Compartment
extracellular region
ReviewStatus
5/5
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Transcytosis and dissociation of botA:NTNHA:HA
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The bacterial botA:NTNHA:HA (BoNT/A:NTNHA:HA) complex, consisting of a Botulinum toxin type A (botA) disulfide bonded heavy chain (HC) - light chain (LC) heterodimer ("dichain") associated with nontoxic nonhemagglutinin protein (NTNHA), three molecules of hemagglutinin (ha) 17, six of ha33, and three of ha70 (Lee et al. 2013), associates with the plasma membrane of a human cell (in vivo, the apical surface of a gut epithelial cell) and undergoes transcytosis. While the molecular details of transcytosis remain to be established definitively, the process enables the toxin heterodimer to cross the epithelial cell layer and enter the circulation (Fujinaga et al. 2013; Simpson 2004).
Literature References
PubMed ID Title Journal Year
23239348 Uptake of botulinum neurotoxin in the intestine

Matsumura, T, Fujinaga, Y, Sugawara, Y

Curr. Top. Microbiol. Immunol. 2013
24130488 Structure of a bimodular botulinum neurotoxin complex provides insights into its oral toxicity

Kruel, AM, Strotmeier, J, Cheng, LW, Lee, K, Rummel, A, Gu, S, Le, TT, Jin, R, Perry, K, Yao, G, Jin, L

PLoS Pathog. 2013
14744243 Identification of the major steps in botulinum toxin action

Simpson, LL

Annu. Rev. Pharmacol. Toxicol. 2004
Participants
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Output
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as an event of
Disease
Name Identifier Synonyms
botulism DOID:11976 Botulism (disorder), Intoxication with Clostridium botulinum toxin, Botulism, Infection due to clostridium botulinum, Botulism, Foodborne botulism, botulism, Botulism, Botulism, Botulism, Food poisoning due to Clostridium botulinum, Botulism poisoning
Authored
Gopinathrao, G  (2006-06-15)
Krupa, S  (2006-06-15)
Reviewed
Ichtchenko, K  (2007-08-03)
Thirunavukkarasu, N  (2014-11-18)
Sharma, S  (2014-11-18)
Created
D'Eustachio, P  (2014-01-15)
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