Reactome | p-S22, S395-LMNA-1 [nucleoplasm]

p-S22, S395-LMNA-1 [nucleoplasm]

Stable Identifier

R-HSA-5229021

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

p-S22, S395-Lamin A

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P02545-1 LMNA

Gene Names

LMNA, LMN1

Participates

as a component of

p-S22, S395-Lamin A dimer [nucleoplasm] (Homo sapiens)

Other forms of this molecule

p-S22, S392-LMNA-1 [nucleoplasm]

p-S395-LMNA-1 [nucleoplasm]

LMNA-1 [cytosol]

LMNA(231-664) [nuclear envelope]

LMNA(1-230) [nuclear envelope]

Lamin A [nucleoplasm]

Inferred To

phospho-p-S22, S395-LMNA-1 [nucleoplasm] (Gallus gallus)

phospho-lmn-1 [nucleoplasm] (Caenorhabditis elegans)

phospho-Lam [nucleoplasm] (Drosophila melanogaster)

phospho-LMNA [nucleoplasm] (Bos taurus)

phospho-LMNA [nucleoplasm] (Canis familiaris)

phospho-LMNA [nucleoplasm] (Sus scrofa)

phospho-lmna [nucleoplasm] (Danio rerio)

phospho-lmna [nucleoplasm] (Xenopus tropicalis)

phospho-Lmna [nucleoplasm] (Mus musculus)

phospho-Lmna [nucleoplasm] (Rattus norvegicus)

Modified Residues

Name

O-phospho-L-serine at 22

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 395

Coordinate

395

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Interactors (90)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P20700 LMNB1	8	LMNB1 [nucleoplasm] (R-HSA-264867) LMNB1(1-231) [nuclear envelope] (R-HSA-352244) LMNB1(232-586) [nuclear envelope] (R-HSA-352248) LMNB1 [cytosol] (R-HSA-2995384) p-S395, S405-LMNB1 [nucleoplasm] (R-HSA-5228738) p-S23, S395, S405-LMNB1 [nucleoplasm] (R-HSA-5229018) LMNB1(2-586) [nuclear envelope] (R-HSA-912402) p-S23,S393-LMNB1 [nucleoplasm] (R-HSA-8868341)	0.933	23
UniProt:Q03252 LMNB2			0.849	10
UniProt:P50402 EMD	4	EMD [nuclear envelope] (R-HSA-201573) EMD [cytosol] (R-HSA-9613988) EMD [endoplasmic reticulum membrane] (R-HSA-9613998) EMD [endosome membrane] (R-HSA-9715092)	0.799	7
UniProt:Q9UII6 DS13B			0.781	7
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.774	23
UniProt:Q9UH99 SUN2	1	SUN2 [nuclear envelope] (R-HSA-912382)	0.723	5
UniProt:O75694 NUP155	2	NUP155 [cytosol] (R-HSA-9634170) NUP155 [nuclear envelope] (R-HSA-157690)	0.672	6
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.666	4
UniProt:P42166 TMPO			0.629	4
UniProt:P16104 H2AFX	7	H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583) Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317)	0.604	3
UniProt:Q0D2I5-5 IFFO1			0.576	4
UniProt:O60684 KPNA6	2	KPNA6 [nucleoplasm] (R-HSA-9734665) KPNA6 [cytosol] (R-HSA-9734672)	0.569	5
UniProt:P42167 TMPO	1	TMPO [cytosol] (R-HSA-9714330)	0.569	4
UniProt:O94901 SUN1	1	SUN1 [nuclear envelope] (R-HSA-912371)	0.564	2
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.564	2
UniProt:P62701 RPS4X	2	RPS4X [cytosol] (R-HSA-72375) RPS4X [nucleoplasm] (R-HSA-6798713)	0.556	3
UniProt:Q3B820 F161A			0.556	3
UniProt:Q7Z699 SPRED1	2	SPRED1 [plasma membrane] (R-HSA-5658225) SPRED1 [cytosol] (R-HSA-5654207)	0.556	3
UniProt:Q96MN9-2 Q96MN92			0.556	3
UniProt:Q7Z698 SPRED2	2	SPRED2 [cytosol] (R-HSA-5654211) SPRED2 [plasma membrane] (R-HSA-5658229)	0.556	3
UniProt:Q96LX8 ZNF597	1	ZNF597 [nucleoplasm] (R-HSA-2127591)	0.556	3
UniProt:Q8WXF7 ATLA1			0.556	3
UniProt:Q86WT6-2 TRIM69			0.556	3
UniProt:Q70EL1-9 USP54			0.556	3
UniProt:Q9C0F3 ZNF436	1	ZNF436 [nucleoplasm] (R-HSA-1247538)	0.556	3
UniProt:P17024 ZNF20	1	ZNF20 [nucleoplasm] (R-HSA-975024)	0.556	3
UniProt:Q9NWB1-5 RBFOX1			0.556	3
UniProt:Q14585 ZN345			0.556	3
UniProt:Q6ZNH5 ZN497			0.556	3
IntAct:EBI-25842396 CCSB			0.556	3
UniProt:P60409 KRTAP10-7	1	KRTAP10-7 [cytosol] (R-HSA-6810279)	0.556	3
UniProt:Q04323-2 UBXN1			0.556	3
IntAct:EBI-10171679 386682			0.556	3
UniProt:Q9BS31 ZNF649	1	ZNF649 [nucleoplasm] (R-HSA-2127585)	0.556	3
UniProt:O43309 ZSC12			0.556	3
UniProt:Q7Z3I7 ZN572			0.556	3
UniProt:Q8IZU1 FAM9A			0.556	3
UniProt:Q9Y4E8-2 USP15			0.556	3
UniProt:Q96EL1 INKA1			0.556	3
UniProt:P46379-2 BAG6			0.556	3
UniProt:Q9HBE1-4 PATZ1			0.556	3
UniProt:Q6H8Q1-8 ABLIM2			0.556	3
UniProt:Q9BZ95-3 Q9BZ953			0.556	3
UniProt:Q8N0Y2-2 ZNF444			0.556	3
UniProt:A6H8Z2-3 A6H8Z23			0.556	3
UniProt:O76041 NEBL			0.556	3
UniProt:Q99612 KLF6			0.556	3
UniProt:Q96GN5-2 CDCA7L			0.556	3
UniProt:Q96KP6 TNIP3	1	TNIP3 [cytosol] (R-HSA-561192)	0.556	3
UniProt:Q8TBE0 BAHD1			0.556	3
UniProt:Q8NEA9 GMCL2			0.556	3
UniProt:Q12986 NFX1			0.556	3
UniProt:Q5VYS8-5 TUT7			0.556	3
UniProt:Q03181-2 PPARD			0.556	3
UniProt:Q8NA54 IQUB			0.556	3
UniProt:Q8WVD3 RNF138	1	RNF138 [cytosol] (R-HSA-976008)	0.556	3
UniProt:Q8TCX5 RHPN1	1	RHPN1 [cytosol] (R-HSA-5667017)	0.556	3
UniProt:Q8TBZ8 ZNF564	1	ZNF564 [nucleoplasm] (R-HSA-1973885)	0.556	3
UniProt:Q14005-2 Q140052			0.556	3
UniProt:Q15776 ZKSCAN8	1	ZKSCAN8 [nucleoplasm] (R-HSA-974985)	0.556	3
UniProt:Q96FA3 PELI1	2	PELI1 [cytosol] (R-HSA-450696) p-PELI1 [cytosol] (R-HSA-450815)	0.556	3
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.556	3
UniProt:Q8WW38 ZFPM2	1	ZFPM2 [nucleoplasm] (R-HSA-996726)	0.556	3
UniProt:O75925 PIAS1	1	PIAS1 [nucleoplasm] (R-HSA-877307)	0.556	3
UniProt:Q9ULD4-2 Q9ULD42			0.556	3
UniProt:Q96DX5 ASB9	1	ASB9 [cytosol] (R-HSA-975424)	0.556	3
UniProt:Q8N488 RYBP	1	RYBP [nucleoplasm] (R-HSA-8937975)	0.556	3
UniProt:Q8IYM2 SLN12			0.556	3
UniProt:Q13123 IK	1	IK [nucleoplasm] (R-HSA-9770239)	0.556	3
UniProt:Q9Y239 NOD1	1	NOD1 [cytosol] (R-HSA-168407)	0.556	3
IntAct:EBI-25851697 CCSB			0.556	3
UniProt:Q3SX64 CMA1D			0.556	3
UniProt:Q6ZN57 ZFP2	1	ZFP2 [nucleoplasm] (R-HSA-975018)	0.556	3
UniProt:Q6X4W1-6 NSMF			0.556	3
UniProt:O75886 STAM2	2	Ub-STAM2 [cytosol] (R-HSA-6782781) STAM2 [cytosol] (R-HSA-182965)	0.556	3
UniProt:Q13133-3 NR1H3			0.556	3
UniProt:P10074 TZAP			0.556	3
UniProt:P58499 FAM3B			0.556	3
UniProt:P54274-2 TERF1			0.556	3
UniProt:P10073 ZSC22			0.556	3
UniProt:Q6ZNE9 RUFY4			0.556	3
UniProt:Q9D666 Sun1	1	Sun1 [nuclear envelope] (R-MMU-912375)	0.528	2
UniProt:O75531 BANF1	4	p-T2,T3,S4-BANF1 [cytosol] (R-HSA-2995375) BANF1 [cytosol] (R-HSA-175371) BANF1 [nucleoplasm] (R-HSA-175030) p-T2,T3,S4-BANF1 [nucleoplasm] (R-HSA-2993896)	0.527	2
UniProt:P17029 ZKSCAN1	1	ZKSCAN1 [nucleoplasm] (R-HSA-975013)	0.527	2
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.527	3
UniProt:P18054 ALOX12	1	ALOX12 [cytosol] (R-HSA-2142768)	0.508	4
UniProt:Q8NC56 LEMD2	1	LEMD2 [nuclear envelope] (R-HSA-3067329)	0.491	2
UniProt:O75937 DNAJC8	1	DNAJC8 [nucleoplasm] (R-HSA-53703)	0.483	3
UniProt:Q9H2H8 PPIL3	1	PPIL3 [nucleoplasm] (R-HSA-8952110)	0.483	2
UniProt:Q8WXH0-1 SYNE2			0.463	3

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