AP4 transports APP from trans-Golgi network to endosome lumen

Stable Identifier
R-HSA-5229111
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
endosome lumen, trans-Golgi network membrane
ReviewStatus
5/5
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AP4 transports APP from trans-Golgi network to endosome lumen
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AP-4 complex subunit mu-1 (AP4M1) can recognise and interact with tyrosine-based (YXXphi) sorting signals found within the cytoplasmic tails of integral membrane proteins such as the amyloid precursor protein (APP), implicated in Alzheimer's disease. Once bound to AP4M1, APP is transported from the trans-Golgi network (TGN) to endosomes, thereby reducing amyloidogenic processing of the protein. Disruption of this interaction decreases localisation of APP to endosomes and enhances gamma-secretase-catalysed cleavage of APP to the pathogenic amyloid-beta peptide (Burgos et al. 2010).
Literature References
PubMed ID Title Journal Year
20230749 Sorting of the Alzheimer's disease amyloid precursor protein mediated by the AP-4 complex

Prabhu, Y, Hurley, JH, Mardones, GA, Burgos, PV, Rojas, AL, Bonifacino, JS, daSilva, LL

Dev. Cell 2010
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein transmembrane transporter activity of AP4:APP [trans-Golgi network membrane]

Physical Entity
AP4:APP [trans-Golgi network membrane] (Homo sapiens)
Activity
protein transmembrane transporter activity (GO:0008320)
Orthologous Events
AP4 transports APP from trans-Golgi network to endosome lumen (Bos taurus)
AP4 transports APP from trans-Golgi network to endosome lumen (Canis familiaris)
AP4 transports APP from trans-Golgi network to endosome lumen (Danio rerio)
AP4 transports APP from trans-Golgi network to endosome lumen (Dictyostelium discoideum)
AP4 transports APP from trans-Golgi network to endosome lumen (Mus musculus)
AP4 transports APP from trans-Golgi network to endosome lumen (Plasmodium falciparum)
AP4 transports APP from trans-Golgi network to endosome lumen (Rattus norvegicus)
AP4 transports APP from trans-Golgi network to endosome lumen (Sus scrofa)
AP4 transports APP from trans-Golgi network to endosome lumen (Xenopus tropicalis)
Authored
Jassal, B  (2014-01-16)
Reviewed
D'Eustachio, P  (2015-02-11)
Created
Jassal, B  (2014-01-16)
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