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PDE4A [cytosol]
Stable Identifier
R-HSA-52383
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
cAMP-specific 3',5'-cyclic phosphodiesterase 4A , DPDE2, PDE46
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Opioid Signalling (Homo sapiens)
DARPP-32 events (Homo sapiens)
PDE4A,C,D hydrolyse cAMP (Homo sapiens)
PDE4A,C,D [cytosol] (Homo sapiens)
PDE4A [cytosol] (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
PDE4A binds PDE4A inhibitors (Homo sapiens)
PDE4A [cytosol] (Homo sapiens)
PDE4A:PDE4A inhibitors [cytosol] (Homo sapiens)
PDE4A [cytosol] (Homo sapiens)
PDE4A hydrolyses cAMP to AMP (Homo sapiens)
PDE4A [cytosol] (Homo sapiens)
cAMP degradation by Phosphodiesterases (Homo sapiens)
cAMP PDEs [cytosol] (Homo sapiens)
Phosphodiesterases, cyclic AMP-selective [cytosol] (Homo sapiens)
PDE4A,C,D [cytosol] (Homo sapiens)
PDE4A [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P27815 PDE4A
Gene Names
PDE4A, DPDE2
Chain
chain:1-886
Reference Genes
BioGPS Gene:5141 PDE4A
COSMIC (genes):PDE4A PDE4A
CTD Gene:5141 PDE4A
dbSNP Gene:5141 PDE4A
ENSEMBL:ENSG00000065989 PDE4A
ENSEMBL_homo_sapiens_GENE:ENSG00000065989.16 PDE4A
HGNC:8780 PDE4A
KEGG Gene (Homo sapiens):5141 PDE4A
Monarch:5141 PDE4A
NCBI Gene:5141 PDE4A
OMIM:600126 PDE4A
UCSC:P27815 PDE4A
Reference Transcript
RefSeq:NM_006202.2 PDE4A
RefSeq:NM_001111309.1 PDE4A
RefSeq:NM_001243121.1 PDE4A
RefSeq:NM_001111308.1 PDE4A
RefSeq:XM_011528054.1 PDE4A
RefSeq:NM_001111307.1 PDE4A
Other Identifiers
11725548_a_at
11725549_a_at
11725550_a_at
11725551_x_at
11738074_a_at
11738075_x_at
11752624_x_at
16858169
204735_PM_at
204735_at
211447_PM_s_at
211447_s_at
211591_PM_s_at
211591_s_at
211901_PM_s_at
211901_s_at
3820502
3820503
3820504
3820507
3820508
3820509
3820514
3820515
3820516
3820517
3820518
3820522
3820523
3820528
3820530
3820531
3820533
3820534
3820535
3820536
3820537
3820539
3820542
3820544
3820545
3820546
3820548
3820549
3820551
3820552
3820553
3820554
3820555
40750_at
47611_at
5141
63677_at
63678_g_at
666_at
8025633
A_24_P322474
A_33_P3395876
GE81609
GO:0003824
GO:0004114
GO:0004115
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005886
GO:0006198
GO:0007165
GO:0007186
GO:0007608
GO:0008081
GO:0010738
GO:0016020
GO:0016787
GO:0019898
GO:0023052
GO:0030552
GO:0032587
GO:0042995
GO:0043226
GO:0046872
GO:0048471
GO:0050877
GO:0055086
GO:0071466
GO:0106070
GO:1901135
HMNXSV003052200
ILMN_1785768
L20965_at
S75213_s_at
TC19000177.hg
TC19001979.hg
TC19001980.hg
U18088_s_at
g12057220_3p_a_at
g347119_3p_a_at
g5453861_3p_at
g604376_3p_s_at
Participates
as a component of
PDE4A:PDE4A inhibitors [cytosol] (Homo sapiens)
as an input of
PDE4A binds PDE4A inhibitors (Homo sapiens)
as a member of
PDE4A,C,D [cytosol] (Homo sapiens)
Inferred To
PDE4A [cytosol]
(Bos taurus)
PDE4A [cytosol]
(Caenorhabditis elegans)
PDE4A [cytosol]
(Canis familiaris)
PDE4A [cytosol]
(Dictyostelium discoideum)
PDE4A [cytosol]
(Drosophila melanogaster)
PDE4A [cytosol]
(Mus musculus)
PDE4A [cytosol]
(Plasmodium falciparum)
PDE4A [cytosol]
(Rattus norvegicus)
PDE4A [cytosol]
(Sus scrofa)
PDE4A [cytosol]
(Xenopus tropicalis)
Homologues of PDE4A [cytosol]
(Dictyostelium discoideum)
Homologues of PDE4A [cytosol]
(Plasmodium falciparum)
Cross References
RefSeq
NP_001104778.1
,
XP_011526356.1
,
NP_001230050.1
,
NP_006193.1
,
NP_001104779.1
,
NP_001104777.1
ZINC - World Drugs
PDE4A_HUMAN
Guide to Pharmacology - Targets
1300
OpenTargets
ENSG00000065989
ZINC - FDA approved
PDE4A_HUMAN
ZINC - Substances
PDE4A_HUMAN
ZINC target
P27815
PRO
P27815
PDB
2QYK
,
3TVX
,
3I8V
ZINC - Investigational
PDE4A_HUMAN
IntEnz
3.1.4.53
HPA
ENSG00000065989-PDE4A
GeneCards
P27815
Ensembl
ENST00000293683
,
ENST00000440014
,
ENSP00000468507
,
ENSP00000394754
,
ENST00000380702
,
ENSG00000065989
,
ENST00000344979
,
ENSP00000341007
,
ENST00000592685
,
ENSP00000293683
,
ENSP00000370078
Pharos - Targets
P27815
ZINC - Predictions - Purchasable
PDE4A_HUMAN
HMDB Protein
HMDBP00650
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