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PDE4D [cytosol]
Stable Identifier
R-HSA-52389
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
cAMP-specific 3',5'-cyclic phosphodiesterase 4D , DPDE3, PDE43
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Opioid Signalling (Homo sapiens)
DARPP-32 events (Homo sapiens)
PDE4A,C,D hydrolyse cAMP (Homo sapiens)
PDE4A,C,D [cytosol] (Homo sapiens)
PDE4D [cytosol] (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
cAMP degradation by Phosphodiesterases (Homo sapiens)
cAMP PDEs [cytosol] (Homo sapiens)
Phosphodiesterases, cyclic AMP-selective [cytosol] (Homo sapiens)
PDE4A,C,D [cytosol] (Homo sapiens)
PDE4D [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q08499 PDE4D
Gene Names
PDE4D, DPDE3
Chain
chain:1-809
Reference Genes
BioGPS Gene:5144 PDE4D
COSMIC (genes):PDE4D PDE4D
CTD Gene:5144 PDE4D
dbSNP Gene:5144 PDE4D
ENSEMBL:ENSG00000113448 PDE4D
ENSEMBL_homo_sapiens_GENE:ENSG00000113448.21 PDE4D
HGNC:8783 PDE4D
KEGG Gene (Homo sapiens):5144 PDE4D
Monarch:5144 PDE4D
NCBI Gene:5144 PDE4D
OMIM:600129 PDE4D
UCSC:Q08499 PDE4D
Reference Transcript
RefSeq:NM_001197219.1 PDE4D
RefSeq:NM_006203.4 PDE4D
RefSeq:NM_001104631.1 PDE4D
RefSeq:XM_017009566.1 PDE4D
RefSeq:XM_011543471.1 PDE4D
RefSeq:NM_001197221.1 PDE4D
RefSeq:NM_001197218.1 PDE4D
RefSeq:NM_001197223.1 PDE4D
RefSeq:NM_001197220.1 PDE4D
RefSeq:XM_005248538.4 PDE4D
RefSeq:XM_011543473.1 PDE4D
RefSeq:NM_001165899.1 PDE4D
RefSeq:NM_001197222.1 PDE4D
Other Identifiers
11724446_a_at
11724447_a_at
11740511_a_at
11740512_x_at
11740513_a_at
11746907_a_at
11760661_at
1554717_PM_a_at
1554717_a_at
204491_PM_at
204491_at
210836_PM_x_at
210836_x_at
210837_PM_s_at
210837_s_at
211840_PM_s_at
211840_s_at
228962_PM_at
228962_at
2858133
2858135
2858136
2858137
2858138
2858139
2858140
2858141
2858142
2858143
2858144
2858145
2858148
2858149
2858150
2858151
2858152
2858154
2858155
2858156
2858166
2858168
2858169
2858174
2858195
2858196
2858209
2858211
2858215
2858221
2858222
2858240
2858241
2858257
2858258
2858290
2858291
2858292
2858345
2858346
2858347
2858368
2858369
2858370
2858384
2858406
2858407
2858408
2858433
38526_at
5144
61634_r_at
77831_at
90755_at
A_23_P124456
A_23_P158406
A_24_P419351
A_24_P944519
A_33_P3389649
A_33_P3389653
A_33_P3389658
GE81610
GO:0002027
GO:0002376
GO:0003012
GO:0003013
GO:0003824
GO:0004114
GO:0004115
GO:0005246
GO:0005515
GO:0005634
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0005891
GO:0006198
GO:0007165
GO:0008081
GO:0010460
GO:0010880
GO:0016020
GO:0016324
GO:0016787
GO:0019899
GO:0019933
GO:0023052
GO:0030154
GO:0030545
GO:0030552
GO:0031698
GO:0032729
GO:0032743
GO:0032754
GO:0033137
GO:0034704
GO:0036211
GO:0043226
GO:0043951
GO:0044325
GO:0045822
GO:0046872
GO:0048471
GO:0048856
GO:0050852
GO:0051117
GO:0055065
GO:0055085
GO:0055086
GO:0061028
GO:0071320
GO:0071872
GO:0071875
GO:0086004
GO:0097110
GO:0098772
GO:1901135
GO:1901363
GO:1901844
GO:1901898
GO:1902514
HMNXSV003051760
Hs.172081.0.S3_3p_at
Hs.28482.0.A1_3p_at
Hs2.172081.3.S1_3p_s_at
ILMN_1791483
PH_hs_0022076
g1236954_3p_a_at
g2735858_3p_a_at
Participates
as a member of
PDE4A,C,D [cytosol] (Homo sapiens)
Inferred To
Homologues of PDE4D [cytosol]
(Dictyostelium discoideum)
Homologues of PDE4D [cytosol]
(Plasmodium falciparum)
PDE4D [cytosol]
(Bos taurus)
PDE4D [cytosol]
(Caenorhabditis elegans)
PDE4D [cytosol]
(Canis familiaris)
PDE4D [cytosol]
(Dictyostelium discoideum)
PDE4D [cytosol]
(Drosophila melanogaster)
PDE4D [cytosol]
(Gallus gallus)
PDE4D [cytosol]
(Mus musculus)
PDE4D [cytosol]
(Plasmodium falciparum)
PDE4D [cytosol]
(Rattus norvegicus)
PDE4D [cytosol]
(Sus scrofa)
PDE4D [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
XP_011541775.1
,
NP_001184149.1
,
NP_001184148.1
,
NP_001184150.1
,
NP_001098101.1
,
XP_005248595.1
,
NP_006194.2
,
XP_016865055.1
,
NP_001184147.1
,
XP_011541773.1
,
NP_001159371.1
,
NP_001184151.1
,
NP_001184152.1
ZINC - World Drugs
PDE4D_HUMAN
Guide to Pharmacology - Targets
1303
OpenTargets
ENSG00000113448
ZINC - FDA approved
PDE4D_HUMAN
ZINC - Substances
PDE4D_HUMAN
ZINC - Biogenic
PDE4D_HUMAN
ZINC target
Q08499
PRO
Q08499
PDB
7AB9
,
1Y2C
,
6FET
,
6LRM
,
7XAB
,
5WQA
,
5K1I
,
6KJZ
,
3IAK
,
6F6U
,
6IMB
,
6FTW
,
1Q9M
,
3G4G
,
6FW3
,
3V9B
,
7XBB
,
6FE7
,
1Y2E
,
2QYN
,
6IM6
,
3SL6
,
6INM
,
5WH5
,
1TBB
,
6F8W
,
1OYN
,
1XOQ
,
1MKD
,
6F8V
,
3G4L
,
6KK0
,
7B9H
,
7F2K
,
3SL3
,
7F2L
,
2FM5
,
6F8T
,
1XOM
,
3G4I
,
1PTW
,
7AY6
,
6NJH
,
6NJI
,
7F2M
,
7ABJ
,
6FEB
,
6RCW
,
6IMD
,
6IND
,
6NJJ
,
6BOJ
,
4WCU
,
3IAD
,
5WH6
,
7AAG
,
7W4Y
,
7A9V
,
3SL4
,
1TB7
,
6IMT
,
1Y2B
,
2PW3
,
7ABE
,
6AKR
,
2FM0
,
6IAG
,
4W1O
,
7CBJ
,
1Y2K
,
1E9K
,
6F8X
,
6ZBA
,
7CBQ
,
6HWO
,
7W4X
,
1Y2D
,
3SL5
,
6IBF
,
7XAA
,
6IMR
,
7YQF
,
6F8U
,
1XON
,
6FDI
,
3G4K
,
7ABD
,
6FT0
,
6FDC
,
1ZKN
,
5TKB
,
4OGB
,
6F8R
,
7A8Q
,
5K32
,
7YSX
,
3K4S
,
5LBO
,
3SL8
,
6IMI
,
6INK
,
3G58
,
6IMO
,
1XOR
,
6FTA
ZINC - Investigational
PDE4D_HUMAN
ZINC - Metabolites
PDE4D_HUMAN
HPA
ENSG00000113448-PDE4D
GeneCards
Q08499
Ensembl
ENST00000503258
,
ENSP00000321739
,
ENST00000502484
,
ENSP00000351800
,
ENST00000317118
,
ENSG00000113448
,
ENSP00000425605
,
ENSP00000384806
,
ENSP00000423094
,
ENST00000507116
,
ENST00000340635
,
ENSP00000353152
,
ENSP00000345502
,
ENSP00000424852
,
ENST00000360047
,
ENST00000502575
,
ENST00000309641
,
ENSP00000308485
,
ENSP00000425917
,
ENST00000358923
,
ENST00000405755
Pharos - Targets
Q08499
Orphanet
21092
ZINC - Predictions - Purchasable
PDE4D_HUMAN
HMDB Protein
HMDBP00636
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P32121 ARRB2
2
ARRB2 [cytosol]
(R-HSA-416464)
PolyUb-ARRB2 [cytosol]
(R-HSA-6783000)
0.564
2
UniProt:Q13077 TRAF1
3
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.556
3
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