Reactome | PDE4D [cytosol]

PDE4D [cytosol]

Stable Identifier

R-HSA-52389

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

cAMP-specific 3',5'-cyclic phosphodiesterase 4D , DPDE3, PDE43

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q08499 PDE4D

Gene Names

PDE4D, DPDE3

Chain

chain:1-809

Reference Genes

BioGPS Gene:5144 PDE4D

COSMIC (genes):PDE4D PDE4D

CTD Gene:5144 PDE4D

dbSNP Gene:5144 PDE4D

ENSEMBL:ENSG00000113448 PDE4D

HGNC:8783 PDE4D

KEGG:hsa:5144 PDE4D

Monarch:5144 PDE4D

NCBI Gene:5144 PDE4D

OMIM:600129 PDE4D

UCSC:Q08499 PDE4D

Reference Transcript

Participates

as a member of

PDE4A,C,D [cytosol] (Homo sapiens)

Inferred To

pde4d [cytosol] (Xenopus tropicalis)

dnc [cytosol] (Drosophila melanogaster)

PDE4D [cytosol] (Bos taurus)

PDE4D [cytosol] (Canis familiaris)

PDE4D [cytosol] (Gallus gallus)

PDE4D [cytosol] (Sus scrofa)

Pde4d [cytosol] (Mus musculus)

Pde4d [cytosol] (Rattus norvegicus)

pde-4 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

XP_047273250.1, XP_054208759.1, XP_011541775.1, XP_011541773.1, XP_047273249.1, NP_001184148.1, NP_001159371.1, NP_001184147.1, NP_001351528.1, XP_054208765.1, XP_054208764.1, XP_054208760.1, XP_005248595.1, XP_054208761.1, NP_001098101.1, NP_001184149.1, XP_054208771.1, XP_054208772.1, XP_054208773.1, NP_006194.2, XP_054208767.1, XP_024301880.1, XP_016865055.1, XP_054208768.1, XP_054208766.1, XP_054208762.1, XP_054208763.1, NP_001184152.1, XP_047273252.1, NP_001184151.1, NP_001184150.1, NP_001351531.1, NP_001351532.1

ZINC - World Drugs

PDE4D_HUMAN

Guide to Pharmacology - Targets

1303

OpenTargets

ENSG00000113448

ENSEMBL

ENST00000502484, ENSG00000113448, ENSP00000321739, ENST00000340635, ENSP00000425605, ENSP00000353152, ENSP00000384806, ENST00000502575, ENST00000503258, ENSP00000345502, ENSP00000308485, ENSP00000425917, ENST00000507116, ENST00000309641, ENST00000360047, ENSP00000351800, ENST00000405755, ENST00000317118, ENSP00000423094, ENST00000358923, ENSP00000424852

ZINC - FDA approved

PDE4D_HUMAN

ZINC - Substances

PDE4D_HUMAN

ZINC - Biogenic

PDE4D_HUMAN

ZINC target

Q08499

PRO

Q08499

GlyGen

Q08499

PDB

6NJH, 8XXS, 8W4R, 3SL3, 6F8W, 6IND, 6FET, 1OYN, 6FTW, 6IBF, 7ABE, 4W1O, 2QYN, 6HWO, 6IMI, 7A9V, 4OGB, 7F2K, 1MKD, 8WDN, 7YQF, 8WDO, 1Y2E, 7CBQ, 1XON, 7AY6, 6F8T, 1ZKN, 1Q9M, 8K4C, 3G4L, 6NJI, 6F8V, 6INK, 8ZQW, 6BOJ, 5WQA, 7AB9, 5TKB, 7ABD, 7W4X, 8YLC, 6IMT, 6FT0, 1TB7, 6ZBA, 7F2L, 3SL5, 6FTA, 6IM6, 6FE7, 5K32, 1PTW, 1XOM, 1Y2C, 7XAA, 3SL8, 3G58, 3IAD, 5K1I, 1TBB, 7YSX, 2FM0, 6IMB, 1Y2K, 7ABJ, 6FDC, 6FDI, 2FM5, 8ZQ1, 7B9H, 7W4Y, 5WH6, 6LRM, 5WH5, 7XBB, 3SL6, 6FW3, 6KJZ, 3V9B, 1Y2B, 1Y2D, 6FEB, 3G4I, 6AKR, 6F8X, 1XOR, 8W4Q, 6NJJ, 3K4S, 8K4H, 5LBO, 8ZQU, 6KK0, 6INM, 6RCW, 4WCU, 8ZQ2, 6IMD, 3IAK, 6IMR, 6IMO, 6F6U, 7F2M, 7CBJ, 6IAG, 7AAG, 7A8Q, 7XAB, 6F8R, 3SL4, 1E9K, 3G4G, 3G4K, 2PW3, 6F8U, 1XOQ

ZINC - Investigational

PDE4D_HUMAN

ZINC - Metabolites

PDE4D_HUMAN

HPA

ENSG00000113448-PDE4D

GeneCards

PDE4D

Pharos - Targets

Q08499

Orphanet

PDE4D

ZINC - Predictions - Purchasable

PDE4D_HUMAN

HMDB Protein

HMDBP00636

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P32121 ARRB2	3	ARRB2 [cytosol] (R-HSA-416464) PolyUb-ARRB2 [cytosol] (R-HSA-6783000) ARRB2 [endocytic vesicle membrane] (R-HSA-9910881)	0.564	2
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.556	3

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