botB:SYT:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane

Stable Identifier
R-HSA-5244402
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Clostridium botulinum
Compartment
ReviewStatus
5/5
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Synaptic vesicles re-form rapidly after exocytosis, carrying vesicle membrane proteins that had been exposed on the cell surface by exocytosis back into the cell (Sudhoff 2004). The botulinum toxin type B disulfide bonded heavy chain - light chain heterodimer (botB HC:LC dimer) bound to ganglioside GT1b and syntagmin 1 or 2 (SYT) is inferred to be taken up as well, delivering it to the re-formed synaptic vesicle.
Literature References
PubMed ID Title Journal Year
15217342 The synaptic vesicle cycle

Südhof, TC

Annu Rev Neurosci 2004
Participants
Participates
Disease
Name Identifier Synonyms
botulism DOID:11976 Botulism (disorder), Intoxication with Clostridium botulinum toxin, Botulism, Infection due to clostridium botulinum, Botulism, Foodborne botulism, botulism, Botulism, Botulism, Botulism, Food poisoning due to Clostridium botulinum, Botulism poisoning
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