Reactome | SETD1B [nucleoplasm]

SETD1B [nucleoplasm]

Stable Identifier

R-HSA-5244714

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Histone-lysine N-methyltransferase SETD1B ecNumber2.1.1.43/ecNumber, SET1B_HUMAN, KMT2G

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Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- Epigenetic regulation of gene expression (Homo sapiens)
  - Formation of WDR5-containing histone-modifying complexes (Homo sapiens)
    - BOD1 binds SET1B complex (Homo sapiens)
      - BOD1:SET1B complex:WDR82:CXXC1 [nucleoplasm] (Homo sapiens)
        
        SET1B complex:WDR82:CXXC1 [nucleoplasm] (Homo sapiens)
        
        SET1B complex [nucleoplasm] (Homo sapiens)
        
        SETD1B [nucleoplasm] (Homo sapiens)
      - SET1B complex:WDR82:CXXC1 [nucleoplasm] (Homo sapiens)
        
        SET1B complex [nucleoplasm] (Homo sapiens)
        
        SETD1B [nucleoplasm] (Homo sapiens)
    - CXXC1 and WDR82 bind SET1B complex (Homo sapiens)
      - SET1B complex [nucleoplasm] (Homo sapiens)
        
        SETD1B [nucleoplasm] (Homo sapiens)
      - SET1B complex:WDR82:CXXC1 [nucleoplasm] (Homo sapiens)
        
        SET1B complex [nucleoplasm] (Homo sapiens)
        
        SETD1B [nucleoplasm] (Homo sapiens)
    - Formation of the SET1B complex (Homo sapiens)
      - SET1B complex [nucleoplasm] (Homo sapiens)
        
        SETD1B [nucleoplasm] (Homo sapiens)
      - SETD1B [nucleoplasm] (Homo sapiens)
- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX1 (Homo sapiens)
      - RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Homo sapiens)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1B complex [nucleoplasm] (Homo sapiens)
        
        SETD1B [nucleoplasm] (Homo sapiens)
        
        H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1B complex [nucleoplasm] (Homo sapiens)
        
        SETD1B [nucleoplasm] (Homo sapiens)
        
        H3K4me3-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1B complex [nucleoplasm] (Homo sapiens)
        
        SETD1B [nucleoplasm] (Homo sapiens)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1B complex [nucleoplasm] (Homo sapiens)
        
        SETD1B [nucleoplasm] (Homo sapiens)
        
        H3K4me2-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1B complex [nucleoplasm] (Homo sapiens)
        
        SETD1B [nucleoplasm] (Homo sapiens)
        
        H3K4me3-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1B complex [nucleoplasm] (Homo sapiens)
        
        SETD1B [nucleoplasm] (Homo sapiens)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Homo sapiens)
        
        H3K4me2-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1B complex [nucleoplasm] (Homo sapiens)
        
        SETD1B [nucleoplasm] (Homo sapiens)
        
        H3K4me3-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1B complex [nucleoplasm] (Homo sapiens)
        
        SETD1B [nucleoplasm] (Homo sapiens)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1B complex [nucleoplasm] (Homo sapiens)
        
        SETD1B [nucleoplasm] (Homo sapiens)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1B complex [nucleoplasm] (Homo sapiens)
        
        SETD1B [nucleoplasm] (Homo sapiens)
        
        H3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1B complex [nucleoplasm] (Homo sapiens)
        
        SETD1B [nucleoplasm] (Homo sapiens)
        
        H3K4me3-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1B complex [nucleoplasm] (Homo sapiens)
        
        SETD1B [nucleoplasm] (Homo sapiens)
        
        GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
        
        H3K4me3-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1B complex [nucleoplasm] (Homo sapiens)
        
        SETD1B [nucleoplasm] (Homo sapiens)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1B complex [nucleoplasm] (Homo sapiens)
        
        SETD1B [nucleoplasm] (Homo sapiens)
        
        ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
        
        H3K4me3-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1B complex [nucleoplasm] (Homo sapiens)
        
        SETD1B [nucleoplasm] (Homo sapiens)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1B complex [nucleoplasm] (Homo sapiens)
        
        SETD1B [nucleoplasm] (Homo sapiens)
        
        MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
        
        H3K4me3-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1B complex [nucleoplasm] (Homo sapiens)
        
        SETD1B [nucleoplasm] (Homo sapiens)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1B complex [nucleoplasm] (Homo sapiens)
        
        SETD1B [nucleoplasm] (Homo sapiens)
        
        RUNX1 and GATA1 bind the promoter of the GP1BA gene (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1B complex [nucleoplasm] (Homo sapiens)
        
        SETD1B [nucleoplasm] (Homo sapiens)
        
        H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1B complex [nucleoplasm] (Homo sapiens)
        
        SETD1B [nucleoplasm] (Homo sapiens)
        
        RUNX1 and GATA1 bind the promoter of the ITGA2B gene (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1B complex [nucleoplasm] (Homo sapiens)
        
        SETD1B [nucleoplasm] (Homo sapiens)
        
        H3K4me2-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1B complex [nucleoplasm] (Homo sapiens)
        
        SETD1B [nucleoplasm] (Homo sapiens)
        
        RUNX1 and GATA1 bind the promoter of the MIR27A gene (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1B complex [nucleoplasm] (Homo sapiens)
        
        SETD1B [nucleoplasm] (Homo sapiens)
        
        H3K4me2-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1B complex [nucleoplasm] (Homo sapiens)
        
        SETD1B [nucleoplasm] (Homo sapiens)
        
        RUNX1 and GATA1 bind the promoter of the THBS1 gene (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1B complex [nucleoplasm] (Homo sapiens)
        
        SETD1B [nucleoplasm] (Homo sapiens)
        
        H3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1B complex [nucleoplasm] (Homo sapiens)
        
        SETD1B [nucleoplasm] (Homo sapiens)
        
        THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
        
        H3K4me3-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1B complex [nucleoplasm] (Homo sapiens)
        
        SETD1B [nucleoplasm] (Homo sapiens)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1B complex [nucleoplasm] (Homo sapiens)
        
        SETD1B [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UPS6 SETD1B

Gene Names

SETD1B, KIAA1076, KMT2G, SET1B

Chain

chain:1-1966

Reference Genes

COSMIC (genes):SETD1B SETD1B

ENSEMBL:ENSG00000139718 SETD1B

ENSEMBL_homo_sapiens_GENE:ENSG00000139718.12 SETD1B

HGNC:29187 SETD1B

OMIM:611055 SETD1B

UCSC:Q9UPS6 SETD1B

Reference Transcript

Other Identifiers

11742418_a_at

16758163

213153_PM_at

213153_at

23067

3434988

3434989

3434990

3434991

3434992

3434993

3434994

3434995

3434996

3434997

3434998

3435003

3435004

3435005

3435007

3435009

3435010

3435011

3435012

3435013

3435016

3435017

3435018

3435019

3435021

3435022

3435023

3435024

3435025

3435026

3435027

3435028

3435032

3435033

3435034

3435035

3435036

3435037

3435038

3435039

38173_at

7959314

A_19_P00809382

A_23_P319895

GE53731

GE538510

GO:0003676

GO:0003723

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0006325

GO:0006338

GO:0008168

GO:0016607

GO:0016740

GO:0032259

GO:0035097

GO:0036211

GO:0042800

GO:0043226

GO:0048188

GO:0051568

GO:0140096

GO:0140938

GO:0140945

GO:0140999

HMNXSV003041149

Hs.154525.0.S1_3p_at

ILMN_1813573

PH_hs_0009302

TC12000963.hg

Participates

as a member of

SUV39H1, SUV39H2, SETDB1, SETDB2 [nucleoplasm] (Homo sapiens)

as an input of

Formation of the SET1B complex (Homo sapiens)

as a component of

SET1B complex [nucleoplasm] (Homo sapiens)

Inferred To

Setd1b [nucleoplasm] (Mus musculus)

Setd1b [nucleoplasm] (Rattus norvegicus)

SETD1B [nucleoplasm] (Bos taurus)

SETD1B [nucleoplasm] (Canis familiaris)

SETD1B [nucleoplasm] (Gallus gallus)

SETD1B [nucleoplasm] (Sus scrofa)

SET1 [nucleoplasm] (Saccharomyces cerevisiae)

setd1b [nucleoplasm] (Xenopus tropicalis)

set1 [nucleoplasm] (Dictyostelium discoideum)

set1 [nucleoplasm] (Schizosaccharomyces pombe)

Set1 [nucleoplasm] (Drosophila melanogaster)

set-2 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

XP_006719359.1, NP_055863.1, XP_005253915.1

Guide to Pharmacology - Targets

2701

OpenTargets

ENSG00000139718

GeneCards

Q9UPS6

HPA

ENSG00000139718-SETD1B

Ensembl

ENST00000619791, ENSP00000481531, ENSP00000474253, ENST00000542440, ENSP00000442924, ENSG00000139718, ENST00000604567

PRO

Q9UPS6

Pharos - Targets

Q9UPS6

Orphanet

29799

HMDB Protein

HMDBP09034

PDB

8ILZ, 3UVO, 4ES0

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.725	4
UniProt:Q9UBL3 ASH2L	1	ASH2L [nucleoplasm] (R-HSA-1629834)	0.527	2

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