Reactome | HSPA4 [nucleoplasm]

HSPA4 [nucleoplasm]

Stable Identifier

R-HSA-5251998

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Heat shock 70 kDa protein 4, HSP74_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P34932 HSPA4

Gene Names

HSPA4, APG2, HSPH2

Chain

chain:1-840

Reference Genes

BioGPS Gene:3308 HSPA4

COSMIC (genes):HSPA4 HSPA4

CTD Gene:3308 HSPA4

dbSNP Gene:3308 HSPA4

ENSEMBL:ENSG00000170606 HSPA4

ENSEMBL_homo_sapiens_GENE:ENSG00000170606.16 HSPA4

HGNC:5237 HSPA4

KEGG Gene (Homo sapiens):3308 HSPA4

Monarch:3308 HSPA4

NCBI Gene:3308 HSPA4

OMIM:601113 HSPA4

UCSC:P34932 HSPA4

Reference Transcript

RefSeq:NM_002154.3 HSPA4

Other Identifiers

11717254_at

11717255_x_at

11751837_a_at

11758770_at

1480_at

16989146

208814_PM_at

208814_at

208815_PM_x_at

208815_x_at

211015_PM_s_at

211015_s_at

211016_PM_x_at

211016_x_at

2828857

2828858

2828861

2828862

2828863

2828865

2828866

2828867

2828871

2828874

2828876

2828878

2828879

2828881

2828882

2828883

2828884

2828885

2828888

2828889

2828892

2828894

2828895

2828896

2828897

2828898

3308

38807_at

8108015

81506_at

A_24_P277511

A_24_P377269

A_24_P377277

GE53658

GO:0000166

GO:0000774

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005739

GO:0005829

GO:0006457

GO:0006886

GO:0006986

GO:0007005

GO:0043226

GO:0044183

GO:0045040

GO:0051131

GO:0061024

GO:0065003

GO:0070062

GO:0098772

GO:0140657

GO:0140662

HMNXSV003040851

Hs.90093.2.S2_3p_at

ILMN_1734814

ILMN_1755134

ILMN_2395043

L12723_at

PH_hs_0005035

TC05000649.hg

g12803406_3p_a_at

g292159_3p_a_at

g4579908_3p_a_at

Participates

as a component of

Other forms of this molecule

HSPA4 [cytosol]

Inferred To

SSE2 [nucleoplasm] (Saccharomyces cerevisiae)

hsp-110 [nucleoplasm] (Caenorhabditis elegans)

HSPA4 [nucleoplasm] (Bos taurus)

HSPA4 [nucleoplasm] (Canis familiaris)

HSPA4 [nucleoplasm] (Sus scrofa)

hspa4 [nucleoplasm] (Xenopus tropicalis)

hspH [nucleoplasm] (Dictyostelium discoideum)

pss1 [nucleoplasm] (Schizosaccharomyces pombe)

Hspa4 [nucleoplasm] (Mus musculus)

Hspa4 [nucleoplasm] (Rattus norvegicus)

SSE1 [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of HSPA4 [nucleoplasm] (Saccharomyces cerevisiae)

hspa4a [nucleoplasm] (Danio rerio)

Cross References

RefSeq

NP_002145.3

OpenTargets

ENSG00000170606

GeneCards

P34932

HPA

ENSG00000170606-HSPA4

Ensembl

ENST00000304858, ENSP00000302961, ENSG00000170606

PRO

P34932

Pharos - Targets

P34932

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P11142 HSPA8	10	Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.787	7
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.668	3
UniProt:Q53H54 TRMT12	1	TRMT12 [cytoplasm] (R-HSA-6782860)	0.527	2
UniProt:Q8WXB1 METTL21A	1	METTL21A [nucleoplasm] (R-HSA-8876682)	0.527	3
UniProt:P07900 HSP90AA1	8	HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.527	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	10

Cite Us!