Reactome | ATP1B4 binds SNW1

ATP1B4 binds SNW1

Stable Identifier

R-HSA-5252001

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nuclear envelope, nucleoplasm

ReviewStatus

5/5

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In fish, amphibian and avian species, ATP1B4 (aka X,K-ATPase subunit beta-m) functions as a subunit of Na/K-ATPase, located in the plasma membrane. In mammals, this functionality is lost and ATP1B4 accumulates on the nuclear envelope where it can interact with SNW domain-containing protein 1 (SNW1 aka Ski-interacting protein, SKIP), a transcriptional regulator. This ATP1B4:SNW1 complex is able to modulate TGF-beta-mediated transcription by increasing mRNA levels of SMAD7, an inhibitor of TGF-beta signalling (Pestov et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17592128	Evolution of Na,K-ATPase beta m-subunit into a coregulator of transcription in placental mammals Radkov, R, Schaer, D, Bibert, S, Geering, K, Roy, S, Ahmad, N, Modyanov, NN, Pestov, NB, Zhao, H, Korneenko, TV	Proc. Natl. Acad. Sci. U.S.A.	2007