ATP6AP1 binds V-ATPase

Stable Identifier
R-HSA-5252133
Type
Reaction [binding]
Species
Homo sapiens
Compartment
early endosome membrane, cytosol
ReviewStatus
5/5
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ATP6AP1 binds V-ATPase
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Vacuolar-type H+-ATPases (V-ATPases) are proton pumps that acidify intracellular cargos and deliver protons across the plasma membrane of many specialised cells. V-type proton ATPase subunit S1 (ATP6AP1) is thought to function as an accessory subunit of the V0 subcomplex of V-ATPase, facilitating acidification (Supek et al. 1994). Experiments with the mouse orthologue reveals a role for Atp6ap1 in osteoclast formation and function (Qin et al. 2011).
Literature References
PubMed ID Title Journal Year
22087256 Versatile roles of V-ATPases accessory subunit Ac45 in osteoclast formation and function

Lin, Z, Dai, KR, Pavlos, NJ, Cheng, TS, Xu, J, Zheng, MH, Jiang, Q, Qin, A

PLoS ONE 2011
7929063 A novel accessory subunit for vacuolar H(+)-ATPase from chromaffin granules

Mandiyan, S, Nelson, H, Supek, F, Nelson, N, Supekova, L, Pan, YC

J. Biol. Chem. 1994
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Orthologous Events
ATP6AP1 binds V-ATPase (Bos taurus)
ATP6AP1 binds V-ATPase (Caenorhabditis elegans)
ATP6AP1 binds V-ATPase (Canis familiaris)
ATP6AP1 binds V-ATPase (Drosophila melanogaster)
ATP6AP1 binds V-ATPase (Mus musculus)
ATP6AP1 binds V-ATPase (Rattus norvegicus)
ATP6AP1 binds V-ATPase (Sus scrofa)
ATP6AP1 binds V-ATPase (Xenopus tropicalis)
Authored
Jassal, B  (2014-02-05)
Reviewed
D'Eustachio, P  (2015-02-11)
Created
Jassal, B  (2014-02-05)
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