Reactome | BAG3 [cytosol]

BAG3 [cytosol]

Stable Identifier

R-HSA-5255451

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

BAG family molecular chaperone regulator 3, BAG3_HUMAN

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to heat stress (Homo sapiens)
    - Regulation of HSF1-mediated heat shock response (Homo sapiens)
      - HSP110s exchange ATP for ADP on HSP70s:ADP (Homo sapiens)
        
        HSP70 NEFs [cytosol] (Homo sapiens)
        
        BAG1-5 [cytosol] (Homo sapiens)
        
        BAG3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O95817 BAG3

Gene Names

BAG3, BIS

Chain

initiator methionine:, chain:2-575

Reference Genes

BioGPS Gene:9531 BAG3

COSMIC (genes):BAG3 BAG3

CTD Gene:9531 BAG3

dbSNP Gene:9531 BAG3

ENSEMBL:ENSG00000151929 BAG3

HGNC:939 BAG3

KEGG:hsa:9531 BAG3

Monarch:9531 BAG3

NCBI Gene:9531 BAG3

OMIM:603883 BAG3

UCSC:O95817 BAG3

Reference Transcript

RefSeq:NM_004281.3 BAG3

Other Identifiers

11757360_s_at

16709856

217911_PM_s_at

217911_s_at

3267315

3267316

3267317

3267318

3267319

3267320

3267324

3267325

3267326

3267328

3267331

3267332

3267333

3267334

3267335

3267336

3267337

48971_at

7930921

9531

A_23_P47077

A_23_P52552

GE81375

GO:0000045

GO:0000774

GO:0001725

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006457

GO:0006886

GO:0006914

GO:0006915

GO:0007018

GO:0008625

GO:0010658

GO:0010664

GO:0012501

GO:0016020

GO:0016235

GO:0030018

GO:0030163

GO:0034605

GO:0034620

GO:0042307

GO:0043066

GO:0043226

GO:0044877

GO:0045296

GO:0045505

GO:0046716

GO:0046827

GO:0050821

GO:0051087

GO:0061684

GO:0070842

GO:0071260

GO:0097192

GO:0098772

GO:0098840

GO:0101031

GO:0140104

GO:0140597

GO:1905337

HMNXSV003051617

ILMN_1659766

PH_hs_0001425

TC10000868.hg

g6631072_3p_s_at

Participates

as a member of

BAG1-5 [cytosol] (Homo sapiens)

Inferred To

bag102 [cytosol] (Schizosaccharomyces pombe)

Homologues of BAG3 [cytosol] (Schizosaccharomyces pombe)

bag3 [cytosol] (Danio rerio)

BAG3 [cytosol] (Bos taurus)

BAG3 [cytosol] (Rattus norvegicus)

BAG3 [cytosol] (Sus scrofa)

Bag3 [cytosol] (Mus musculus)

bag101 [cytosol] (Schizosaccharomyces pombe)

Cross References

ENSEMBL

ENST00000369085, ENSP00000358081

OpenTargets

ENSG00000151929

HPA

ENSG00000151929-BAG3

PRO

O95817

Pharos - Targets

O95817

GlyGen

O95817

Orphanet

BAG3

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.822	7
UniProt:Q9Y5V3 MAGED1	1	MAGED1 [cytosol] (R-HSA-196002)	0.718	6
UniProt:P11142 HSPA8	10	HSPA8 [cytosol] (R-HSA-264476) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217)	0.671	5
UniProt:Q00613 HSF1	11	HSF1 [cytosol] (R-HSA-3371452) p-S326-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082355) hC36,103-HSF1 [nucleoplasm] (R-HSA-3371416) Ac-K80-hC36,103-HSF1 [nucleoplasm] (R-HSA-5097238) p-S230-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082361) hC36,103-HSF1 [cytosol] (R-HSA-4793916) HSF1 [nucleoplasm] (R-HSA-5082385) p-S303,307-HSF1 [cytosol] (R-HSA-4793922) p-S307-HSF1 [cytosol] (R-HSA-4793929) p-S303-HSF1 [cytosol] (R-HSA-4793927) p-S121-HSF1 [cytosol] (R-HSA-4793906)	0.638	3
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.623	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	15
UniProt:P07196 NEFL	1	NEFL [cytosol] (R-HSA-432284)	0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P14373 TRIM27	2	TRIM27 [cytosol] (R-HSA-8851002) TRIM27 [nucleoplasm] (R-HSA-2997690)	0.556	3
UniProt:Q96RU7 TRIB3	3	TRIB3 [plasma membrane] (R-HSA-199447) TRIB3 [cytosol] (R-HSA-162411) TRIB3 [nucleoplasm] (R-HSA-9635877)	0.556	3
UniProt:A8MTQ0 NOTO	1	NOTO [nucleoplasm] (R-HSA-9796216)	0.556	3
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.556	3
UniProt:P50570 DNM2	5	DNM2 [Golgi membrane] (R-HSA-2980842) DNM2 [endocytic vesicle membrane] (R-HSA-2029000) DNM2 [cytosol] (R-HSA-2213180) DNM2 [lysosomal membrane] (R-HSA-2980840) DNM2 [plasma membrane] (R-HSA-2984201)	0.556	3
UniProt:O14641 DVL2	5	DVL2 [cytosol] (R-HSA-201694) pp-DVL2 [cytosol] (R-HSA-3772398) p-DVL2 [cytosol] (R-HSA-201706) p-DVL2 [clathrin-coated endocytic vesicle] (R-HSA-5138444) ub-DVL2 [cytosol] (R-HSA-4652689)	0.553	2
UniProt:Q13501 SQSTM1	7	SQSTM1 [cytosol] (R-HSA-193937) SQSTM1 [nucleoplasm] (R-HSA-210961) ub K420 p-S349 SQSTM1 [cytosol] (R-HSA-9766536) p-S349 SQSTM1 [cytosol] (R-HSA-9766524) K7 ub-SQSTM1 [cytosol] (R-HSA-9759088) SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711954) SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711967)	0.537	3
UniProt:Q8WXB1 METTL21A	1	METTL21A [nucleoplasm] (R-HSA-8876682)	0.527	3
UniProt:Q7Z6Z6 PNPLA5	1	PNPLA5 [cytosol] (R-HSA-8848346)	0.527	2

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