Reactome | CYP1A1 [endoplasmic reticulum membrane]

CYP1A1 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-52623

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

CYPIA1, Cytochrome P450 1A1 , P450-P1, P450 form 6, P450-C

Locations in the PathwayBrowser for interactor UniProt:Q96A49 SYAP1

Expand all

External Reference Information

External Reference

UniProt:P04798 CYP1A1

Gene Names

CYP1A1

Chain

chain:1-512

Reference Genes

BioGPS Gene:1543 CYP1A1

COSMIC (genes):CYP1A1 CYP1A1

CTD Gene:1543 CYP1A1

dbSNP Gene:1543 CYP1A1

ENSEMBL:ENSG00000140465 CYP1A1

ENSEMBL_homo_sapiens_GENE:ENSG00000140465.15 CYP1A1

HGNC:2595 CYP1A1

KEGG Gene (Homo sapiens):1543 CYP1A1

Monarch:1543 CYP1A1

NCBI Gene:1543 CYP1A1

OMIM:108330 CYP1A1

UCSC:P04798 CYP1A1

Reference Transcript

Other Identifiers

1024_at

1025_g_at

11726536_at

11754154_a_at

1543

16811684

205749_PM_at

205749_at

3601834

3633082

3633083

3633084

3633085

3633087

3633089

3633090

3633091

3633092

3633093

3633094

3633095

36767_at

7990391

A_23_P163402

GE57540

GO:0000278

GO:0001666

GO:0001676

GO:0001889

GO:0002933

GO:0003824

GO:0004497

GO:0005506

GO:0005515

GO:0005737

GO:0005739

GO:0005743

GO:0005783

GO:0005789

GO:0006629

GO:0006631

GO:0006694

GO:0006766

GO:0006778

GO:0006805

GO:0008202

GO:0008210

GO:0008391

GO:0008395

GO:0009308

GO:0009404

GO:0009410

GO:0009624

GO:0009635

GO:0009636

GO:0009692

GO:0009804

GO:0009812

GO:0010033

GO:0010041

GO:0014070

GO:0016020

GO:0016491

GO:0016679

GO:0016705

GO:0016711

GO:0016712

GO:0016829

GO:0017143

GO:0018894

GO:0019341

GO:0019373

GO:0019825

GO:0019899

GO:0020037

GO:0022414

GO:0030154

GO:0030544

GO:0032094

GO:0032451

GO:0032496

GO:0033189

GO:0035902

GO:0042359

GO:0042572

GO:0042759

GO:0042904

GO:0043010

GO:0043226

GO:0043231

GO:0046209

GO:0046483

GO:0046685

GO:0046872

GO:0048565

GO:0048771

GO:0048856

GO:0050665

GO:0051879

GO:0055093

GO:0060137

GO:0070330

GO:0070365

GO:0070576

GO:0071280

GO:0071407

GO:0097267

GO:0101020

GO:0101021

GO:0102033

GO:0106256

GO:0120319

GO:1900087

GO:1904681

HMNXSV003001350

PH_hs_0004186

TC15001647.hg

X02612_at

g13325053_3p_at

Participates

as a member of

as an output of

Expression of CYP1A1 (Homo sapiens)

Inferred To

cyp1a [endoplasmic reticulum membrane] (Danio rerio)

CYP1A1 [endoplasmic reticulum membrane] (Bos taurus)

CYP1A1 [endoplasmic reticulum membrane] (Gallus gallus)

CYP1A1 [endoplasmic reticulum membrane] (Mus musculus)

CYP1A1 [endoplasmic reticulum membrane] (Rattus norvegicus)

CYP1A1 [endoplasmic reticulum membrane] (Sus scrofa)

Cross References

RefSeq

NP_001306145.1, NP_001306146.1, NP_000490.1

ZINC - World Drugs

CP1A1_HUMAN

Guide to Pharmacology - Targets

1318

OpenTargets

ENSG00000140465

ZINC - FDA approved

CP1A1_HUMAN

ZINC - Substances

CP1A1_HUMAN

ZINC target

P04798

ZINC - Biogenic

CP1A1_HUMAN

PRO

P04798

PDB

6UDL, 6DWN, 6O5Y, 4I8V, 6UDM, 6DWM

ZINC - Investigational

CP1A1_HUMAN

ZINC - Metabolites

CP1A1_HUMAN

GeneCards

P04798

HPA

ENSG00000140465-CYP1A1

Ensembl

ENSP00000456585, ENSP00000378488, ENSP00000455340, ENSP00000455051, ENST00000564596, ENST00000562201, ENST00000567032, ENST00000569630, ENSP00000457668, ENSG00000140465, ENST00000379727, ENSP00000369050, ENST00000395048

Pharos - Targets

P04798

ZINC - Predictions - Purchasable

CP1A1_HUMAN

Orphanet

24450

HMDB Protein

HMDBP01555

Interactors (25)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96DZ9-2 CMTM5			0.556	3
UniProt:Q96DZ9 CKLF5			0.556	3
UniProt:Q9GZZ1 NAA50			0.527	2
UniProt:Q9Y3A5 SBDS			0.527	2
UniProt:Q00341 HDLBP	1	HDLBP [plasma membrane] (R-HSA-8858026)	0.527	2
UniProt:P29144 TPP2	1	TPP2 [cytosol] (R-HSA-983068)	0.527	2
UniProt:O95202 LETM1	2	LETM1 [endoplasmic reticulum membrane] (R-HSA-9714759) LETM1 [mitochondrial inner membrane] (R-HSA-8949702)	0.527	2
UniProt:P46063 RECQ1			0.527	2
UniProt:Q9UM19 HPCL4			0.527	2
UniProt:Q15813 TBCE	1	TBCE [cytosol] (R-HSA-379539)	0.527	2
UniProt:Q96A49 SYAP1			0.527	2
UniProt:O60493 SNX3	3	SNX3 [cytosol] (R-HSA-3247743) PolyUb-SNX3 [endosome membrane] (R-HSA-6782993) SNX3 [endosome membrane] (R-HSA-6782991)	0.527	2
UniProt:P37235 HPCL1			0.527	2
UniProt:Q92530 PSMF1	2	PSMF1 [nucleoplasm] (R-HSA-174308) PSMF1 [cytosol] (R-HSA-68818)	0.527	2
UniProt:Q8NFH5 NUP35	2	NUP35 [cytosol] (R-HSA-9634171) NUP35 [nuclear envelope] (R-HSA-157748)	0.527	2
UniProt:Q99986 VRK1	2	VRK1 [nucleoplasm] (R-HSA-2528998) VRK1 [cytosol] (R-HSA-2995381)	0.527	2
UniProt:O75822 EIF3J	1	EIF3J [cytosol] (R-HSA-72534)	0.527	2
UniProt:O75844 FACE1			0.527	2
UniProt:P19525 EIF2AK2	5	p-EIF2AK2 [nucleoplasm] (R-HSA-9836332) SUMO-EIF2AK2 [cytosol] (R-HSA-9834829) ISG15-EIF2AK2 [cytosol] (R-HSA-9833968) p-EIF2AK2 [cytosol] (R-HSA-9833834) EIF2AK2 [cytosol] (R-HSA-168699)	0.527	2
UniProt:P62495 ETF1	3	Me-Q185-ETF1 [cytosol] (R-HSA-6800157) 4OHK63-ETF1 [cytosol] (R-HSA-9629948) ETF1 [cytosol] (R-HSA-54433)	0.527	2
UniProt:Q9BY44 EIF2A			0.527	2
UniProt:Q13526 PIN1	2	PIN1 [cytosol] (R-HSA-9626823) PIN1 [nucleoplasm] (R-HSA-936016)	0.527	2
UniProt:Q9NTZ6 RBM12			0.527	2
UniProt:Q562R1 ACTBL			0.527	2
UniProt:O60885 BRD4	1	BRD4 [nucleoplasm] (R-HSA-9680425)	0.527	2

Cite Us!