Reactome | GMPPA [cytosol]

GMPPA [cytosol]

Stable Identifier

R-HSA-532565

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Mannose-1-phosphate guanyltransferase alpha, GMPPA_HUMAN

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        Synthesis of GDP-mannose (Homo sapiens)
        
        Mannose-1-phosphate converted to GDP-Mannose (Homo sapiens)
        
        GMPPA/B [cytosol] (Homo sapiens)
        
        GMPPA [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96IJ6 GMPPA

Gene Names

GMPPA

Chain

chain:1-420

Reference Genes

BioGPS Gene:29926 GMPPA

COSMIC (genes):GMPPA GMPPA

CTD Gene:29926 GMPPA

dbSNP Gene:29926 GMPPA

ENSEMBL:ENSG00000144591 GMPPA

ENSEMBL_homo_sapiens_GENE:ENSG00000144591.20 GMPPA

HGNC:22923 GMPPA

KEGG Gene (Homo sapiens):29926 GMPPA

Monarch:29926 GMPPA

NCBI Gene:29926 GMPPA

OMIM:615495 GMPPA

UCSC:Q96IJ6 GMPPA

Reference Transcript

Other Identifiers

11744114_a_at

11747459_a_at

16891349

17122344

218070_PM_s_at

218070_s_at

2528621

2528622

2528623

2528624

2528625

2528626

2528627

2528630

2528631

2528632

2528633

2528635

2528636

2528637

2528638

2528639

2528640

2528642

2528643

2528644

2528646

2528647

29926

57166_at

8048595

GE55671

GO:0003824

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0009058

GO:0016740

GO:0043226

GO:0070062

HMNXSV003034740

ILMN_1693878

ILMN_1804476

PH_hs_0002398

TC02001329.hg

TC02003843.hg

g11761616_3p_a_at

Participates

as a member of

GMPPA/B [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_016859398.1, XP_005246543.1, XP_016859400.1, NP_995319.1, NP_037467.2, XP_016859399.1

OpenTargets

ENSG00000144591

GeneCards

Q96IJ6

HPA

ENSG00000144591-GMPPA

Ensembl

ENST00000341142, ENST00000622191, ENST00000313597, ENSP00000315925, ENSP00000340760, ENSP00000506941, ENSP00000478700, ENSP00000363016, ENSG00000144591, ENSP00000350949, ENSP00000363027, ENST00000358215, ENST00000373917, ENST00000683946, ENST00000373908

PRO

Q96IJ6

Pharos - Targets

Q96IJ6

Orphanet

22589

HMDB Protein

HMDBP03737

PDB

7D74, 7D72, 7D73

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q01658 DR1	1	DR1 [nucleoplasm] (R-HSA-3662280)	0.556	3
UniProt:Q92917 GPKOW	1	GPKOW [nucleoplasm] (R-HSA-8850839)	0.556	3

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