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CYCS [cytosol]
Stable Identifier
R-HSA-53259
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Cytochrome c
Icon
Locations in the PathwayBrowser
Expand all
Organelle biogenesis and maintenance (Homo sapiens)
Mitochondrial biogenesis (Homo sapiens)
Transcriptional activation of mitochondrial biogenesis (Homo sapiens)
Expression of CYCS (Homo sapiens)
CYCS [cytosol] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Intrinsic Pathway for Apoptosis (Homo sapiens)
Apoptotic factor-mediated response (Homo sapiens)
Cytochrome c-mediated apoptotic response (Homo sapiens)
Activation of caspases through apoptosome-mediated cleavage (Homo sapiens)
Cleavage of Procaspase-3 by the apoptosome (Homo sapiens)
Apoptosome [cytosol] (Homo sapiens)
APAF1:CYCS [cytosol] (Homo sapiens)
CYCS [cytosol] (Homo sapiens)
Cleavage of Procaspase-7 by the apoptosome (Homo sapiens)
Apoptosome [cytosol] (Homo sapiens)
APAF1:CYCS [cytosol] (Homo sapiens)
CYCS [cytosol] (Homo sapiens)
Formation of apoptosome (Homo sapiens)
CYCS binds to APAF1 (Homo sapiens)
APAF1:ATP:CYCS [cytosol] (Homo sapiens)
CYCS [cytosol] (Homo sapiens)
CYCS [cytosol] (Homo sapiens)
CYCS:APAF1 binds procaspase-9 (Homo sapiens)
APAF1:ATP:CYCS [cytosol] (Homo sapiens)
CYCS [cytosol] (Homo sapiens)
APAF1:ATP:CYCS heptamer:CASP9 [cytosol] (Homo sapiens)
APAF1:ATP:CYCS [cytosol] (Homo sapiens)
CYCS [cytosol] (Homo sapiens)
Cleavage of Procaspase‑9 to caspase‑9 (Homo sapiens)
APAF1:CYCS:ATP:CASP9(1-416)dimer [cytosol] (Homo sapiens)
APAF1:CYCS [cytosol] (Homo sapiens)
CYCS [cytosol] (Homo sapiens)
Apoptosome [cytosol] (Homo sapiens)
APAF1:CYCS [cytosol] (Homo sapiens)
CYCS [cytosol] (Homo sapiens)
Procaspase 9 forms dimer (Homo sapiens)
APAF1:ATP:CYCS heptamer:CASP9 [cytosol] (Homo sapiens)
APAF1:ATP:CYCS [cytosol] (Homo sapiens)
CYCS [cytosol] (Homo sapiens)
APAF1:CYCS:ATP:CASP9(1-416)dimer [cytosol] (Homo sapiens)
APAF1:CYCS [cytosol] (Homo sapiens)
CYCS [cytosol] (Homo sapiens)
Regulation of the apoptosome activity (Homo sapiens)
APAF1:CYCS binds APIP (Homo sapiens)
APAF1:ATP:CYCS heptamer:CASP9 [cytosol] (Homo sapiens)
APAF1:ATP:CYCS [cytosol] (Homo sapiens)
CYCS [cytosol] (Homo sapiens)
APAF1:CYCS:ATP:APIP [cytosol] (Homo sapiens)
APAF1:ATP:CYCS heptamer:CASP9 [cytosol] (Homo sapiens)
APAF1:ATP:CYCS [cytosol] (Homo sapiens)
CYCS [cytosol] (Homo sapiens)
CASP9 is phosphorylated at T125 (Homo sapiens)
APAF1:ATP:CYCS heptamer:CASP9 [cytosol] (Homo sapiens)
APAF1:ATP:CYCS [cytosol] (Homo sapiens)
CYCS [cytosol] (Homo sapiens)
APAF1:ATP:CYCS heptamer:p-T125-CASP9 [cytosol] (Homo sapiens)
APAF1:ATP:CYCS [cytosol] (Homo sapiens)
CYCS [cytosol] (Homo sapiens)
UACA binds apoptosome (Homo sapiens)
Apoptosome [cytosol] (Homo sapiens)
APAF1:CYCS:ATP:CASP9(1-416)dimer [cytosol] (Homo sapiens)
APAF1:CYCS [cytosol] (Homo sapiens)
CYCS [cytosol] (Homo sapiens)
Apoptosome [cytosol] (Homo sapiens)
APAF1:CYCS [cytosol] (Homo sapiens)
CYCS [cytosol] (Homo sapiens)
UACA:apoptosome [cytosol] (Homo sapiens)
Apoptosome [cytosol] (Homo sapiens)
APAF1:CYCS:ATP:CASP9(1-416)dimer [cytosol] (Homo sapiens)
APAF1:CYCS [cytosol] (Homo sapiens)
CYCS [cytosol] (Homo sapiens)
Apoptosome [cytosol] (Homo sapiens)
APAF1:CYCS [cytosol] (Homo sapiens)
CYCS [cytosol] (Homo sapiens)
XIAP binds CASP9 (Homo sapiens)
Apoptosome [cytosol] (Homo sapiens)
APAF1:CYCS [cytosol] (Homo sapiens)
CYCS [cytosol] (Homo sapiens)
XIAP:apoptosome [cytosol] (Homo sapiens)
Apoptosome [cytosol] (Homo sapiens)
APAF1:CYCS [cytosol] (Homo sapiens)
CYCS [cytosol] (Homo sapiens)
Release of apoptotic factors from the mitochondria (Homo sapiens)
Release of Cytochrome c from mitochondria (Homo sapiens)
CYCS [cytosol] (Homo sapiens)
SMAC, XIAP-regulated apoptotic response (Homo sapiens)
SMAC (DIABLO) binds to IAPs (Homo sapiens)
SMAC binds XIAP within apoptosome (Homo sapiens)
APAF1:CYCS:CASP9:XIAP:DIABLO [cytosol] (Homo sapiens)
Apoptosome [cytosol] (Homo sapiens)
APAF1:CYCS [cytosol] (Homo sapiens)
CYCS [cytosol] (Homo sapiens)
XIAP:apoptosome [cytosol] (Homo sapiens)
Apoptosome [cytosol] (Homo sapiens)
APAF1:CYCS [cytosol] (Homo sapiens)
CYCS [cytosol] (Homo sapiens)
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes (Homo sapiens)
Dissociation of DIABLO:XIAP from the apoptosome complex (Homo sapiens)
APAF1:CYCS:CASP9:XIAP:DIABLO [cytosol] (Homo sapiens)
Apoptosome [cytosol] (Homo sapiens)
APAF1:CYCS [cytosol] (Homo sapiens)
CYCS [cytosol] (Homo sapiens)
Apoptosome [cytosol] (Homo sapiens)
APAF1:CYCS [cytosol] (Homo sapiens)
CYCS [cytosol] (Homo sapiens)
Regulated Necrosis (Homo sapiens)
Pyroptosis (Homo sapiens)
Release of Cytochrome c from mitochondria (Homo sapiens)
CYCS [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P99999 CYCS
Gene Names
CYCS, CYC
Chain
initiator methionine:1, chain:2-105
Reference Genes
BioGPS Gene:54205 CYCS
COSMIC (genes):CYCS CYCS
CTD Gene:54205 CYCS
dbSNP Gene:54205 CYCS
ENSEMBL:ENSG00000172115.9 CYCS
HGNC:19986 CYCS
KEGG Gene (Homo sapiens):54205 CYCS
Monarch:54205 CYCS
NCBI Gene:54205 CYCS
OMIM:123970 CYCS
UCSC:P99999 CYCS
Reference Transcript
RefSeq:NM_018947.5 CYCS
Other Identifiers
0006770184
11722003_at
11722004_s_at
11753803_x_at
17055970
17124130
208905_PM_at
208905_at
229415_PM_at
229415_at
244546_PM_at
244546_at
2904075
3042002
3042003
3042004
3042005
3042006
3042007
3042008
3042009
3042010
3042011
3130960
3130961
3130962
35818_at
54205
70396_at
8138640
83749_at
A_24_P29665
A_24_P573978
A_32_P174083
GE61580
GO:0005515
GO:0005622
GO:0005634
GO:0005737
GO:0005739
GO:0005743
GO:0005758
GO:0005829
GO:0006091
GO:0006122
GO:0006123
GO:0006915
GO:0008635
GO:0009055
GO:0012501
GO:0016491
GO:0020037
GO:0022900
GO:0023052
GO:0032991
GO:0043226
GO:0043280
GO:0043293
GO:0045333
GO:0046872
GO:0051604
GO:0070469
GO:0097193
GO:0097202
HMNXSV003054060
Hs.157301.0.A1_3p_at
Hs.205711.0.A1_3p_at
ILMN_1730416
M22877_at
PH_hs_0025571
TC07001207.hg
g13529022_3p_at
Participates
as an output of
Expression of CYCS (Homo sapiens)
Release of Cytochrome c from mitochondria (Homo sapiens)
as an input of
CYCS binds to APAF1 (Homo sapiens)
as a component of
APAF1:ATP:CYCS [cytosol] (Homo sapiens)
APAF1:CYCS [cytosol] (Homo sapiens)
Other forms of this molecule
CYCS [mitochondrial intermembrane space]
CYCS [mitochondrial inner membrane]
AcK-CYCS [mitochondrial intermembrane space]
Inferred To
RGD1562558 [cytosol]
(Rattus norvegicus)
cyct [cytosol]
(Xenopus tropicalis)
CYCS [cytosol]
(Bos taurus)
CYCS [cytosol]
(Caenorhabditis elegans)
CYCS [cytosol]
(Canis familiaris)
CYCS [cytosol]
(Danio rerio)
CYCS [cytosol]
(Dictyostelium discoideum)
CYCS [cytosol]
(Drosophila melanogaster)
CYCS [cytosol]
(Gallus gallus)
CYCS [cytosol]
(Plasmodium falciparum)
CYCS [cytosol]
(Rattus norvegicus)
CYCS [cytosol]
(Saccharomyces cerevisiae)
CYCS [cytosol]
(Schizosaccharomyces pombe)
CYCS [cytosol]
(Sus scrofa)
CYCS [cytosol]
(Xenopus tropicalis)
Homologues of CYCS [cytosol]
(Caenorhabditis elegans)
Homologues of CYCS [cytosol]
(Drosophila melanogaster)
Homologues of CYCS [cytosol]
(Gallus gallus)
Homologues of CYCS [cytosol]
(Plasmodium falciparum)
Homologues of CYCS [cytosol]
(Rattus norvegicus)
Homologues of CYCS [cytosol]
(Saccharomyces cerevisiae)
Homologues of CYCS [cytosol]
(Sus scrofa)
Homologues of CYCS [cytosol]
(Xenopus tropicalis)
LOC690675 [cytosol]
(Rattus norvegicus)
Cycs [cytosol]
(Mus musculus)
LOC100519295 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_061820.1
OpenTargets
ENSG00000172115
HPA
ENSG00000172115-CYCS
GeneCards
P99999
Ensembl
ENST00000305786
,
ENSP00000307786
,
ENST00000409409
,
ENST00000409764
,
ENSP00000387279
,
ENSG00000172115
,
ENSP00000386270
PRO
P99999
Pharos - Targets
P99999
Orphanet
17975
HMDB Protein
HMDBP01762
PDB
6XNK
,
2N9J
,
5O10
,
5TY3
,
2N9I
,
1J3S
,
3NWV
,
5EXQ
,
6ECJ
,
6DUJ
,
3ZOO
,
3ZCF
,
2N3Y
Interactors (29)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q6A162 KRT40
1
KRT40 [cytosol]
(R-HSA-6809605)
0.718
6
UniProt:O14727 APAF1
4
APAF1 [secretory granule lumen]
(R-HSA-6801271)
APAF1 [extracellular region]
(R-HSA-6806465)
APAF1 [ficolin-1-rich granule lumen]
(R-HSA-6801301)
APAF1 [cytosol]
(R-HSA-50099)
0.688
6
UniProt:Q9FKS5 CYC1B
0.558
2
UniProt:P37840 SNCA
4
SNCA A30P [cytosol]
(R-HSA-5658569)
SNCA [extracellular region]
(R-HSA-976954)
SNCA [cytosol]
(R-HSA-5658500)
Ub-SNCA [cytosol]
(R-HSA-5660754)
0.556
3
UniProt:Q8N5Z5 KCD17
0.556
3
UniProt:Q8IYG6 LRC56
0.556
3
UniProt:Q3SXR2 CC036
0.556
3
UniProt:Q9BUL5 PHF23
0.556
3
UniProt:Q3SYB3 FX4L6
0.556
3
UniProt:Q6ZMI0-5 PPP1R21
0.556
3
UniProt:Q6XD76 ASCL4
0.556
3
UniProt:A0A0A0MR05 A0A0A0MR05
0.556
3
IntAct:EBI-25835866 CCSB
0.556
3
UniProt:Q9UKG9-2 Q9UKG92
0.556
3
UniProt:O00303 EIF3F
1
EIF3F [cytosol]
(R-HSA-72540)
0.556
3
UniProt:Q6FHY5 Q6FHY5
0.556
3
UniProt:Q9NTN9-3 SEMA4G
0.556
3
UniProt:Q1L5Z9 LONF2
0.556
3
UniProt:O43829 ZBT14
0.556
3
UniProt:Q8IZU1 FAM9A
0.556
3
UniProt:Q96BR5 COA7
0.556
3
UniProt:Q66K80 RUAS1
0.556
3
UniProt:Q92797-2 Q927972
0.556
3
UniProt:Q9NSI6-4 BRWD1
0.556
3
UniProt:P06241 FYN
6
p-S21,Y420-FYN [cytosol]
(R-HSA-5218745)
p-Y531-FYN [cytosol]
(R-HSA-391819)
MyrG2-PalmC3,6-FYN [plasma membrane]
(R-HSA-9606873)
p-Y420-FYN [cytosol]
(R-HSA-391821)
MyrG-p-Y420-FYN [plasma membrane]
(R-HSA-1810410)
FYN [cytosol]
(R-HSA-200917)
0.556
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:Q13573 SNW1
1
SNW1 [nucleoplasm]
(R-HSA-351663)
0.556
3
UniProt:P06429 VE7
0.553
2
UniProt:Q9Y4K3 TRAF6
8
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [endosome membrane]
(R-HSA-450272)
0.536
2
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