Reactome | 80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC

80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC

Stable Identifier

R-HSA-5333615

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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General

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80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC

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The complex consisting of selenocysteinyl (Sec) transfer RNA (tRNA) for Sec (Sec-tRNASec), selenocysteine-specific elongation factor (EEFSEC) aka SelB, selenocysteine insertion sequence-binding protein 2 (SECISBP2) aka SBP2 and GTP interacts with the 80S ribosomal protein complex (80S:Met-tRNAi:mRNA). This triggers the hydrolysis of GTP (to GDP) by EEFSEC and delivery of Sec-tRNASec to the ribosomal A site. Before the Sec residue is inserted into the nascent polypeptide chain, EEFSEC:GDP is released. This reaction is inferred from events occurring in rats.

Literature References

PubMed ID	Title	Journal	Year
15821744	Ribosomal protein L30 is a component of the UGA-selenocysteine recoding machinery in eukaryotes Chavatte, L, Driscoll, DM, Brown, BA	Nat. Struct. Mol. Biol.	2005