TCF7L2 K485fs*25 [nucleoplasm]

Stable Identifier
R-HSA-5334040
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
TCF7L2 K485fs*25 [nucleoplasm] icon
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
10919662 The human T-cell transcription factor-4 gene: structure, extensive characterization of alternative splicings, and mutational analysis in colorectal cancer cell lines

Rolland, S, Duval, A, Thomas, G, Tubacher, E, Hamelin, R, Bui, H

Cancer Res. 2000
16547505 TCF-4 isoforms absent in TCF-4 mutated MSI-H colorectal cancer cells colocalize with nuclear CtBP and repress TCF-4-mediated transcription

Duval, A, El-Bchiri, J, Cuilliere-Dartigues, P, Hamelin, R, Fontanges, P, Buhard, O, Fléjou, JF, Krimi, A

Oncogene 2006
Participates
Other forms of this molecule
Modified Residues
Name
Replacement of residues 485 to 506 by SAFATYKVKAAASAHPLQMEAY
Disease
Name Identifier Synonyms
colorectal cancer DOID:9256
stomach cancer DOID:10534 malignant neoplasm of greater curvature of stomach, unspecified, malignant neoplasm of lesser curvature of stomach, NOS, malignant tumor of body of stomach (disorder), neoplasm of stomach (disorder), Ca lesser curvature - stomach (disorder), malignant neoplasm of greater curve of stomach unspecified (disorder), Ca body - stomach, ca lesser curvature of stomach, ca greater curvature of stomach, malignant neoplasm of lesser curvature of stomach, unspecified, malignant tumor of lesser curve of stomach (disorder), malignant neoplasm of body of stomach, gastric neoplasm, malignant neoplasm of greater curvature of stomach, NOS, Ca body - stomach (disorder), stomach neoplasm, Ca greater curvature - stomach (disorder), malignant neoplasm of lesser curve of stomach unspecified (disorder), malignant tumor of greater curve of stomach (disorder)
Interactors (6)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P35222 CTNNB1  20 0.97 27
 UniProt:Q13761 RUNX3  7 0.656 14
 UniProt:Q08050 FOXM1  3 0.612 7
 UniProt:Q14526 HIC1  2 0.61 6
 UniProt:P09874 PARP1  4 0.597 6
 UniProt:Q9UER7 DAXX  13 0.543 5
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