Reactome | HBEGF(20-208) [endocytic vesicle membrane]

HBEGF(20-208) [endocytic vesicle membrane]

Stable Identifier

R-HSA-5334776

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endocytic vesicle membrane

Synonyms

HBEGF, pro-HBEGF, Proheparin-binding EGF-like growth factor

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External Reference Information

External Reference

UniProt:Q99075 HBEGF

Gene Names

HBEGF, DTR, DTS, HEGFL

Chain

signal peptide:1-19, chain:20-208, propeptide:20-62, chain:63-148, propeptide:149-208

Reference Genes

BioGPS Gene:1839 HBEGF

COSMIC (genes):HBEGF HBEGF

CTD Gene:1839 HBEGF

dbSNP Gene:1839 HBEGF

ENSEMBL:ENSG00000113070 HBEGF

ENSEMBL_homo_sapiens_GENE:ENSG00000113070.8 HBEGF

HGNC:3059 HBEGF

KEGG Gene (Homo sapiens):1839 HBEGF

Monarch:1839 HBEGF

NCBI Gene:1839 HBEGF

OMIM:126150 HBEGF

UCSC:Q99075 HBEGF

Reference Transcript

RefSeq:NM_001945.2 HBEGF

Other Identifiers

11719898_s_at

11755981_a_at

17000724

1839

203821_PM_at

203821_at

2878274

2878275

2878276

2878278

2878281

2878283

2878284

2878285

2878286

38037_PM_at

38037_at

8114572

A_23_P213944

A_24_P140608

GE81091

GO:0003013

GO:0005102

GO:0005154

GO:0005515

GO:0005576

GO:0005615

GO:0005886

GO:0007165

GO:0007173

GO:0007517

GO:0008016

GO:0008083

GO:0008201

GO:0008284

GO:0009986

GO:0016020

GO:0016477

GO:0023052

GO:0030297

GO:0030307

GO:0030335

GO:0030666

GO:0030669

GO:0031410

GO:0035313

GO:0036211

GO:0038134

GO:0038135

GO:0042060

GO:0043226

GO:0048018

GO:0048661

GO:0048856

GO:0048870

GO:0050731

GO:0051545

GO:0051549

GO:0051897

GO:0060326

GO:0090303

GO:0098772

GO:1901135

HMNXSV003003454

ILMN_2121408

M60278_at

PH_hs_0000094

TC05001854.hg

g4503412_3p_s_at

Participates

as an output of

DT fragment B transports DT fragment A from target cell endosome membrane (Homo sapiens)

as a component of

DT:HBEGF:CD9 [endocytic vesicle membrane] (Homo sapiens)

Other forms of this molecule

HBEGF(63-148) [clathrin-coated endocytic vesicle membrane]

HBEGF(20-208) [clathrin-coated endocytic vesicle membrane]

HB-EGF(161-208) [plasma membrane]

HBEGF(20-62) [extracellular region]

HBEGF(149-208) [extracellular region]

HBEGF(20-208) [plasma membrane]

HBEGF(63-148) [extracellular region]

Cross References

RefSeq

NP_001936.1

OpenTargets

ENSG00000113070

HPA

ENSG00000113070-HBEGF

GeneCards

Q99075

Ensembl

ENSP00000230990, ENST00000230990, ENSG00000113070

PRO

Q99075

Pharos - Targets

Q99075

PDB

2M8S, 1XDT

HMDB Protein

HMDBP02701

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.609	3
UniProt:P22607 FGFR3	20	FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 805fs*141 [plasma membrane] (R-HSA-1614387) FGFR3 [plasma membrane] (R-HSA-2038357) FGFR3 S371C [plasma membrane] (R-HSA-1614421) FGFR3 Y373C [plasma membrane] (R-HSA-1614424) FGFR3 G370C [plasma membrane] (R-HSA-1614394) FGFR3 R248C [plasma membrane] (R-HSA-1614419)	0.556	3
UniProt:P06396 GSN	7	GSN(200-270) [extracellular region] (R-HSA-976940) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(404-782) [cytosol] (R-HSA-350272) GSN(28-403) [cytosol] (R-HSA-201618) GSN [cytosol] (R-HSA-350275)	0.556	3

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