Reactome | SUMO-K-CRABP1 [cytosol]

SUMO-K-CRABP1 [cytosol]

Stable Identifier

R-HSA-5334807

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Cellular retinoic acid-binding protein 1, RABP1_HUMAN

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External Reference Information

External Reference

UniProt:P29762 CRABP1

Gene Names

CRABP1, RBP5

Chain

chain:1-137

Reference Genes

BioGPS Gene:1381 CRABP1

COSMIC (genes):CRABP1 CRABP1

CTD Gene:1381 CRABP1

dbSNP Gene:1381 CRABP1

ENSEMBL:ENSG00000166426 CRABP1

ENSEMBL:ENSG00000166426.8 CRABP1

HGNC:2338 CRABP1

KEGG Gene (Homo sapiens):1381 CRABP1

Monarch:1381 CRABP1

NCBI Gene:1381 CRABP1

OMIM:180230 CRABP1

UCSC:P29762 CRABP1

Reference Transcript

RefSeq:NM_004378.2 CRABP1

Other Identifiers

11723047_at

1381

16803492

205350_PM_at

205350_at

3603296

3603297

3603299

3603302

3603304

3603305

49212_at

542_at

543_g_at

7985159

A_33_P3216869

A_33_P3326483

GE58806

GO:0005501

GO:0005504

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0007165

GO:0008289

GO:0015908

GO:0016918

GO:0019841

GO:0023052

GO:0043226

HMNXSV003007730

PH_hs_0016729

S74445_at

TC15000728.hg

g4758051_3p_at

Participates

as an output of

CYP26A1,B1,C1 4-hydroxylate atRA (Homo sapiens)

as a component of

SUMO-CRABP1:atRA [cytosol] (Homo sapiens)

as an input of

CRABP1 binds atRA (Homo sapiens)

Inferred To

crabp1 [cytosol] (Xenopus tropicalis)

Homologues of SUMO-K-CRABP1 [cytosol] (Caenorhabditis elegans)

lbp-8 [cytosol] (Caenorhabditis elegans)

CRABP1 [cytosol] (Sus scrofa)

SUMO-K-CRABP1 [cytosol] (Bos taurus)

SUMO-K-CRABP1 [cytosol] (Caenorhabditis elegans)

SUMO-K-CRABP1 [cytosol] (Danio rerio)

SUMO-K-CRABP1 [cytosol] (Gallus gallus)

SUMO-K-CRABP1 [cytosol] (Mus musculus)

SUMO-K-CRABP1 [cytosol] (Rattus norvegicus)

fabp [cytosol] (Drosophila melanogaster)

lbp-7 [cytosol] (Caenorhabditis elegans)

Modified Residues

Name

sumoylated lysine at unknown position

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

NP_004369.1

Guide to Pharmacology - Targets

2529

OpenTargets

ENSG00000166426

GeneCards

P29762

HPA

ENSG00000166426-CRABP1

Ensembl

ENSG00000166426, ENST00000299529, ENSP00000299529

PRO

P29762

Pharos - Targets

P29762

HMDB Protein

HMDBP01924

PDB

7A9Z, 7A9Y

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O14745 NHRF1			0.556	3
UniProt:P07101-3 TH			0.556	3
UniProt:P27958-PRO_0000037576			0.508	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.508	4

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