Reactome | LRPPRC [mitochondrial matrix]

LRPPRC [mitochondrial matrix]

Stable Identifier

R-HSA-5336174

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

Leucine-rich PPR motif-containing protein, mitochondrial, LPPRC_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P42704 LRPPRC

Gene Names

LRPPRC, LRP130

Chain

transit peptide:1-59, chain:60-1394

Reference Genes

BioGPS Gene:10128 LRPPRC

COSMIC (genes):LRPPRC LRPPRC

CTD Gene:10128 LRPPRC

dbSNP Gene:10128 LRPPRC

ENSEMBL:ENSG00000138095 LRPPRC

ENSEMBL_homo_sapiens_GENE:ENSG00000138095.20 LRPPRC

HGNC:15714 LRPPRC

KEGG Gene (Homo sapiens):10128 LRPPRC

Monarch:10128 LRPPRC

NCBI Gene:10128 LRPPRC

OMIM:607544 LRPPRC

UCSC:P42704 LRPPRC

Reference Transcript

RefSeq:NM_133259.3 LRPPRC

Other Identifiers

10128

11717296_s_at

11717297_at

11717298_s_at

11745328_a_at

16897056

211615_PM_s_at

211615_s_at

211971_PM_s_at

211971_s_at

230194_PM_at

230194_at

2550796

2550797

2550798

2550799

2550800

2550801

2550802

2550803

2550806

2550810

2550812

2550814

2550815

2550816

2550818

2550821

2550825

2550826

2550830

2550832

2550837

2550838

2550840

2550841

2550842

2550843

2550844

2550845

2550846

2550847

2550848

2550849

2550853

2550858

2550860

2550861

2550867

2550869

2550871

2550873

2550875

2550876

2550877

2550878

2550879

2550880

2550885

2550886

41754_at

58758_s_at

8051882

A_24_P26073

A_24_P674924

A_33_P3388855

GE62712

GO:0000228

GO:0000794

GO:0000957

GO:0000961

GO:0003677

GO:0003697

GO:0003723

GO:0003730

GO:0005515

GO:0005634

GO:0005635

GO:0005637

GO:0005640

GO:0005654

GO:0005694

GO:0005737

GO:0005739

GO:0005759

GO:0005856

GO:0005874

GO:0007018

GO:0008017

GO:0008092

GO:0016020

GO:0031625

GO:0042645

GO:0043226

GO:0047497

GO:0048471

GO:0048487

GO:0051028

GO:0070129

GO:0140053

GO:1990904

HMNXSV003001028

HMNXSV003029701

HMNXSV003034655

Hs.182490.0.S1_3p_s_at

Hs.54310.0.A1_3p_at

ILMN_1662417

M92439_at

PH_hs_0010771

TC02001795.hg

g177109_3p_s_at

Participates

as a component of

SLIRP:LRPPRC [mitochondrial matrix] (Homo sapiens)

Cross References

RefSeq

NP_573566.2

OpenTargets

ENSG00000138095

HPA

ENSG00000138095-LRPPRC

GeneCards

P42704

Ensembl

ENSG00000138095, ENSP00000260665, ENST00000260665

PRO

P42704

Pharos - Targets

P42704

Orphanet

16373

PDB

8ANY

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.669	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.584	8
UniProt:P06730 EIF4E	1	EIF4E [cytosol] (R-HSA-72578)	0.576	6
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.564	2
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.527	2
UniProt:Q9NZI8 IGF2BP1	1	IGF2BP1 [cytosol] (R-HSA-428366)	0.527	2
UniProt:Q9UBK2 PPARGC1A	4	monoSUMO1-K184-PPARGC1A [nucleoplasm] (R-HSA-3903023) p-T263,S266,T299-PPARGC1A [nucleoplasm] (R-HSA-1592224) p-T178,S539-PPARGC1A [nucleoplasm] (R-HSA-1592204) PPARGC1A [nucleoplasm] (R-HSA-442481)	0.524	2
UniProt:P63000 RAC1	6	RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) RAC1 [cytosol] (R-HSA-442615) RAC1 [plasma membrane] (R-HSA-351141)	0.508	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	9
UniProt:P05919 vpu	6	VPU (P05919) protein [cytosol] (R-HIV-173223) VPU (P05919) [endoplasmic reticulum membrane] (R-HIV-180550) VPU (P05919) protein [extracellular region] (R-HIV-175522) VPU (P05919) protein [nucleoplasm] (R-HIV-175200) VPU (P05919) [Golgi membrane] (R-HIV-3149439) VPU (P05919) [plasma membrane] (R-HIV-3149423)	0.462	4

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