LIN7, CASK and APBA1 bind

Stable Identifier
R-HSA-5336443
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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LIN7, CASK and APBA1 bind
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In brain, a complex of three proteins form a tripartite complex which may act to couple synaptic vesicle exocytosis to neuronal cell adhesion. Any of the three protein lin7 homologs A, B or C (LIN7A,B or C) can bind to amyloid beta A4 precursor protein-binding family A member 1 (APBA1 aka MINT1) and peripheral plasma membrane protein CASK (aka LIN2) (Butz et al. 1998). All of these proteins contain PDZ domains, not used in complex formation thus able to recruit adhesion molecules, receptors and channels to the complex.
Literature References
PubMed ID Title Journal Year
9753324 A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain

Südhof, TC, Okamoto, M, Butz, S

Cell 1998
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Orthologous Events
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LIN7, CASK and APBA1 bind (Xenopus tropicalis)
Authored
Jassal, B  (2014-03-03)
Reviewed
D'Eustachio, P  (2015-02-11)
Created
Jassal, B  (2014-03-03)
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