Reactome | MMGT1 transports Mg2+ from cytosol to Golgi lumen

MMGT1 transports Mg2+ from cytosol to Golgi lumen

Stable Identifier

R-HSA-5336454

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi lumen, Golgi membrane, cytosol

ReviewStatus

5/5

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MMGT1 transports Mg2+ from cytosol to Golgi lumen

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Magnesium (Mg2+) is required for the catalytic activity of numerous metalloenzymes within a variety of subcellular organelles. Membrane magnesium transporter 1 (MMGT1) mediates the uptake of Mg2+ across the Golgi membrane. The human MMGT1 function is inferred from mouse experiments using the orthologous Mmgt1 and 2 (Goytain & Quamme 2008). MMGT1 is also found on the ER membrane as a component of the ER membrane protein complex (EMC) which functions to degrade incorrectly folded or assembled proteins by a ubiquitin- and proteasome-dependent process known as ER-associated degradation (ERAD). MMGT1 is not implicated in this function of protein quality control (Christianson et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
22119785	Defining human ERAD networks through an integrative mapping strategy Tyler, RE, Bennett, EJ, Christianson, JC, Kopito, RR, Greenblatt, EJ, Sowa, ME, Olzmann, JA, Harper, JW, Richter, CM, Shaler, TA	Nat. Cell Biol.	2012
18057121	Identification and characterization of a novel family of membrane magnesium transporters, MMgT1 and MMgT2 Goytain, A, Quamme, GA	Am. J. Physiol., Cell Physiol.	2008