Reactome | APBA1 [cytosol]

APBA1 [cytosol]

Stable Identifier

R-HSA-5336459

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Amyloid beta A4 precursor protein-binding family A member 1, APBA1_HUMAN, MINT1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q02410 APBA1

Gene Names

APBA1, MINT1, X11

Chain

chain:1-837

Reference Genes

BioGPS Gene:320 APBA1

COSMIC (genes):APBA1 APBA1

CTD Gene:320 APBA1

dbSNP Gene:320 APBA1

ENSEMBL:ENSG00000107282 APBA1

ENSEMBL:ENSG00000107282.9 APBA1

HGNC:578 APBA1

KEGG Gene (Homo sapiens):320 APBA1

Monarch:320 APBA1

NCBI Gene:320 APBA1

OMIM:602414 APBA1

UCSC:Q02410 APBA1

Reference Transcript

Other Identifiers

11725859_at

11725860_at

17094700

206679_PM_at

206679_at

228101_PM_at

228101_at

320

3208773

3208774

3208775

3208776

3208777

3208780

3208790

3208791

3208794

3208798

3208801

3208803

3208806

3208807

3208810

3208823

3208824

3208825

3208826

3208827

3208828

3208839

36698_at

58428_at

8161618

A_33_P3295650

A_33_P3295655

GE54403

GE586029

GO:0001540

GO:0001701

GO:0005515

GO:0005634

GO:0005737

GO:0005794

GO:0005829

GO:0005886

GO:0006886

GO:0007018

GO:0007155

GO:0007268

GO:0007399

GO:0007626

GO:0008021

GO:0008088

GO:0010468

GO:0014047

GO:0014051

GO:0015031

GO:0016020

GO:0023052

GO:0031410

GO:0035264

GO:0043197

GO:0043226

GO:0048471

GO:0048787

GO:0048856

GO:0051649

GO:0065003

GO:0098685

GO:0098978

GO:0099171

HMNXSV003021635

Hs.171939.0.A1_3p_at

ILMN_1668285

ILMN_2182656

L04953_at

PH_hs_0000496

PH_hs_0010294

TC09001193.hg

TC09002585.hg

Participates

as a component of

as a candidate of

MINT1,2,(3) [cytosol] (Homo sapiens)

as an input of

LIN7, CASK and APBA1 bind (Homo sapiens)

Inferred To

Apba1 [cytosol] (Mus musculus)

Apba1 [cytosol] (Rattus norvegicus)

APBA1 [cytosol] (Bos taurus)

APBA1 [cytosol] (Canis familiaris)

APBA1 [cytosol] (Danio rerio)

APBA1 [cytosol] (Gallus gallus)

APBA1 [cytosol] (Sus scrofa)

apba1 [cytosol] (Xenopus tropicalis)

Homologues of APBA1 [cytosol] (Drosophila melanogaster)

X11L [cytosol] (Drosophila melanogaster)

X11Lbeta [cytosol] (Drosophila melanogaster)

lin-10 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001154.2, XP_016870159.1, XP_005252025.1, XP_011516919.1

OpenTargets

ENSG00000107282

GeneCards

Q02410

HPA

ENSG00000107282-APBA1

Ensembl

ENSG00000107282, ENSP00000265381, ENST00000265381

PRO

Q02410

Pharos - Targets

Q02410

PDB

1U38, 1X11, 1U37, 1U39, 1AQC, 1Y7N, 1U3B, 1X45

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.729	5
UniProt:P49768 PSEN1	6	PSEN1(1-467) [plasma membrane] (R-HSA-201606) PSEN1(299-467) [azurophil granule membrane] (R-HSA-6799234) PSEN1(1-467) [azurophil granule membrane] (R-HSA-6799235) PSEN1(1-298) [azurophil granule membrane] (R-HSA-6799209) PSEN1(1-298) [plasma membrane] (R-HSA-2534298) PSEN1(299-467) [plasma membrane] (R-HSA-2534245)	0.697	4