Reactome | GLTP transports GSL from plasma membrane to ER membrane

GLTP transports GSL from plasma membrane to ER membrane

Stable Identifier

R-HSA-5340320

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, endoplasmic reticulum membrane

Synonyms

GLTP transports glycosphingolipids from plasma membrane to ER membrane

ReviewStatus

5/5

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GLTP transports GSL from plasma membrane to ER membrane

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Glycolipid transfer protein (GLTP) is a monomeric, soluble protein that can mediate the intermembrane transport of glycosphingolipids (GSLs) (Malinina et al., 2004; Malinina et al., 2006; Tuuf & Mattjus 2007). GLTPs could be potential regulators of cell processes mediated by GSLs, such as differentiation and proliferation to invasive adhesion, neurodegeneration, and apoptosis (reviewed in Mishra et al., 2020). This reaction shows one example of GSL transfer from the plasma membrane to the ER membrane.

Literature References

PubMed ID	Title	Journal	Year
17980653	Human glycolipid transfer protein--intracellular localization and effects on the sphingolipid synthesis Mattjus, P, Tuuf, J	Biochim. Biophys. Acta	2007
32339554	Emerging roles for human glycolipid transfer protein superfamily members in the regulation of autophagy, inflammation, and cell death Chalfant, CE, Hinchcliffe, EH, Mishra, SK, Gao, YG, Zou, X, Stephenson, DJ, Malinina, L, Brown, RE	Prog Lipid Res	2020
17105344	The liganding of glycolipid transfer protein is controlled by glycolipid acyl structure Abagyan, R, Lu, M, Kanack, AT, Malinina, L, Malakhova, ML, Patel, DJ, Brown, RE	PLoS Biol.	2006
15329726	Structural basis for glycosphingolipid transfer specificity Teplov, A, Malinina, L, Malakhova, ML, Patel, DJ, Brown, RE	Nature	2004