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HAVCR2 [plasma membrane]
Stable Identifier
R-HSA-5340408
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Hepatitis A virus cellular receptor 2, HAVR2_HUMAN
Locations in the PathwayBrowser for interactor UniProt:O00459 PIK3R2
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-2 family signaling (Homo sapiens)
HAVCR2 binds LGALS9 (Homo sapiens)
HAVCR2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8TDQ0 HAVCR2
Gene Names
HAVCR2, TIM3, TIMD3
Chain
signal peptide:1-21, chain:22-301
Reference Genes
BioGPS Gene:84868 HAVCR2
COSMIC (genes):HAVCR2 HAVCR2
CTD Gene:84868 HAVCR2
dbSNP Gene:84868 HAVCR2
ENSEMBL:ENSG00000135077 HAVCR2
ENSEMBL_homo_sapiens_GENE:ENSG00000135077.10 HAVCR2
HGNC:18437 HAVCR2
KEGG Gene (Homo sapiens):84868 HAVCR2
Monarch:84868 HAVCR2
NCBI Gene:84868 HAVCR2
OMIM:606652 HAVCR2
UCSC:Q8TDQ0 HAVCR2
Reference Transcript
RefSeq:NM_032782.4 HAVCR2
Other Identifiers
11728228_at
11728229_a_at
1554285_PM_at
1554285_at
1555628_PM_a_at
1555628_a_at
17002141
235458_PM_at
235458_at
2883350
2883351
2883352
2883353
2883354
2883355
2883356
2883358
2883360
2883361
2883362
2883364
2883369
2883371
2883372
75648_at
8115464
84868
A_23_P18903
A_24_P923370
GE83516
GO:0001772
GO:0001819
GO:0002250
GO:0002281
GO:0002376
GO:0002519
GO:0002652
GO:0002826
GO:0002838
GO:0002859
GO:0005515
GO:0005634
GO:0005768
GO:0005769
GO:0005886
GO:0006351
GO:0006355
GO:0006357
GO:0006954
GO:0007155
GO:0009986
GO:0010629
GO:0016020
GO:0016592
GO:0022414
GO:0023052
GO:0030886
GO:0031410
GO:0032088
GO:0032480
GO:0032687
GO:0032689
GO:0032703
GO:0032712
GO:0032715
GO:0032720
GO:0032722
GO:0032729
GO:0032732
GO:0032753
GO:0032760
GO:0032815
GO:0034138
GO:0034154
GO:0034162
GO:0042102
GO:0042130
GO:0043032
GO:0043226
GO:0045087
GO:0045089
GO:0045824
GO:0046872
GO:0048856
GO:0050830
GO:0060135
GO:0070161
GO:0070374
GO:0071222
GO:0071656
GO:0098542
GO:1900425
GO:1900426
GO:1901224
GO:2000521
GO:2001189
HMNXSV003037666
Hs.155111.0.A1_3p_at
Hs2.155111.2.S1_3p_at
Hs2.155111.3.A1_3p_a_at
ILMN_1693826
PH_hs_0009342
PH_hs_0031885
TC05003434.hg
Participates
as a component of
HAVCR2:LGALS9 [plasma membrane] (Homo sapiens)
as an input of
HAVCR2 binds LGALS9 (Homo sapiens)
Cross References
RefSeq
NP_116171.3
Guide to Pharmacology - Targets
2940
OpenTargets
ENSG00000135077
HPA
ENSG00000135077-HAVCR2
GeneCards
Q8TDQ0
Ensembl
ENST00000696899
,
ENSP00000512960
,
ENSG00000135077
,
ENSP00000312002
,
ENST00000307851
PRO
Q8TDQ0
Pharos - Targets
Q8TDQ0
Orphanet
28031
PDB
6TXZ
,
7M41
,
5F71
,
7M3Z
,
6DHB
,
7M3Y
,
8HGJ
,
7KQL
,
5DZL
Interactors (48)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P27986 PIK3R1
16
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 [cytosol]
(R-HSA-74789)
PIK3R1 [plasma membrane]
(R-HSA-198365)
0.597
3
UniProt:P13688 CEACAM1
3
CEACAM1 [specific granule membrane]
(R-HSA-6799528)
CEACAM1 [plasma membrane]
(R-HSA-197701)
CEACAM1 [tertiary granule membrane]
(R-HSA-6800953)
0.591
4
UniProt:Q96IW7 SEC22A
3
SEC22A [ER to Golgi transport vesicle membrane]
(R-HSA-5688560)
SEC22A [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5688562)
SEC22A [endoplasmic reticulum membrane]
(R-HSA-5216111)
0.556
3
UniProt:Q8N2M4 TM86A
0.556
3
UniProt:P36894 BMPR1A
2
BMPR1A [plasma membrane]
(R-HSA-201480)
p-4S-BMPR1A [plasma membrane]
(R-HSA-201448)
0.527
2
UniProt:O14939 PLD2
2
PLD2 [plasma membrane]
(R-HSA-2029075)
PLD2 [endoplasmic reticulum membrane]
(R-HSA-1498791)
0.527
2
UniProt:P42338 PIK3CB
1
PIK3CB [cytosol]
(R-HSA-74788)
0.527
2
UniProt:P0C7P0 CISD3
0.527
2
UniProt:Q8TCG2 PI4K2B
1
PI4K2B [cytosol]
(R-HSA-1604675)
0.527
2
UniProt:Q643R3 LPCAT4
1
LPCAT4 [endoplasmic reticulum membrane]
(R-HSA-1498768)
0.527
2
UniProt:Q96S97 MYADM
0.527
3
UniProt:O00459 PIK3R2
3
PIK3R2 [cytosol]
(R-HSA-74791)
K63polyUb-PIK3R2 [cytosol]
(R-HSA-3080554)
p-Y464-PIK3R2 [cytosol]
(R-HSA-9860512)
0.527
2
UniProt:O94955 RHOBTB3
1
RHOBTB3 [trans-Golgi network membrane]
(R-HSA-6813908)
0.527
2
UniProt:Q9Y2I1 NISCH
1
NISCH [cytosol]
(R-HSA-9691384)
0.527
2
UniProt:Q08357 SLC20A2
7
SLC20A2 V195Lfs*61 [plasma membrane]
(R-HSA-5625150)
SLC20A2 L170* [plasma membrane]
(R-HSA-5625074)
SLC20A2 [plasma membrane]
(R-HSA-427661)
SLC20A2 G498R [plasma membrane]
(R-HSA-5625140)
SLC20A2 S601L [plasma membrane]
(R-HSA-5625095)
SLC20A2 T595M [plasma membrane]
(R-HSA-5625111)
SLC20A2 S610Afs*17 [plasma membrane]
(R-HSA-5625137)
0.527
2
UniProt:O94832 MYO1D
0.527
2
UniProt:O95789 ZMYM6
0.527
2
UniProt:Q96BI1 SLC22A18
3
SLC22A18 [plasma membrane]
(R-HSA-561110)
SLC22A18 S233F [plasma membrane]
(R-HSA-5625564)
SLC22A18 R286H [plasma membrane]
(R-HSA-5625583)
0.527
2
UniProt:Q8NB78 KDM1B
1
KDM1B [nucleoplasm]
(R-HSA-5423072)
0.527
2
UniProt:P27037 ACVR2A
1
ACVR2A [plasma membrane]
(R-HSA-201659)
0.527
2
UniProt:Q8TCT0 CERK
1
CERK [plasma membrane]
(R-HSA-1631584)
0.527
2
UniProt:Q92569 PIK3R3
2
PIK3R3 [cytosol]
(R-HSA-205223)
K63polyUb-PIK3R3 [cytosol]
(R-HSA-3080574)
0.527
2
UniProt:Q969X6 UTP4
1
CIRH1A [nucleoplasm]
(R-HSA-6790662)
0.527
2
UniProt:Q14680 MELK
0.527
2
UniProt:Q6P5Z2 PKN3
2
p-T718-PKN3 [cytosol]
(R-HSA-5623654)
PKN3 [cytosol]
(R-HSA-5623611)
0.527
2
UniProt:P52824 DGKQ
1
DGKQ [plasma membrane]
(R-HSA-426062)
0.527
2
UniProt:Q53EQ6 TIGD5
0.527
2
UniProt:Q8IWF6 DENND6A
1
DENND6A [cytosol]
(R-HSA-8876587)
0.527
2
UniProt:Q7Z5G4 GOLGA7
3
GOLGA7 [extracellular region]
(R-HSA-6800449)
GOLGA7 [tertiary granule lumen]
(R-HSA-6800164)
GOLGA7 [Golgi membrane]
(R-HSA-9647777)
0.527
2
UniProt:A6NFQ2 TCAF2
0.527
2
UniProt:Q5TCX8 M3K21
0.527
2
UniProt:Q9P265 DIP2B
0.527
2
UniProt:Q16513 PKN2
2
p-T816-PKN2 [cytosol]
(R-HSA-5623652)
PKN2 [cytosol]
(R-HSA-5623612)
0.527
2
UniProt:O60346 PHLPP1
1
PHLPP1 [cytosol]
(R-HSA-199421)
0.527
2
UniProt:P78357 CNTNAP1
1
CNTNAP1 [plasma membrane]
(R-HSA-373626)
0.527
2
UniProt:O00443 PIK3C2A
3
PIK3C2A [Golgi membrane]
(R-HSA-432679)
PIK3C2A [cytosol]
(R-HSA-1604624)
PIK3C2A [cytoplasmic vesicle membrane]
(R-HSA-432683)
0.527
2
UniProt:P23458 JAK1
6
p-Y1034,Y1035-JAK1 [cytosol]
(R-HSA-9005335)
JAK1 [endosome]
(R-HSA-8983168)
p-JAK1 [cytosol]
(R-HSA-8950711)
p-Y1034-JAK1 [cytosol]
(R-HSA-1112543)
JAK1 [cytosol]
(R-HSA-451898)
p-Y-JAK1 [cytosol]
(R-HSA-451921)
0.527
2
UniProt:Q99943 AGPAT1
1
AGPAT1 [endoplasmic reticulum membrane]
(R-HSA-61803)
0.527
3
UniProt:P29597 TYK2
5
p-TYK2 [cytosol]
(R-HSA-8950424)
p-Y-TYK2 [cytosol]
(R-HSA-6784366)
TYK2 [cytosol]
(R-HSA-877348)
p-Y1054,Y1055-TYK2 [cytosol]
(R-HSA-909682)
p-Y1054-TYK2 [cytosol]
(R-HSA-1112598)
0.527
2
UniProt:P41732 TSPAN7
1
TSPAN7 [plasma membrane]
(R-HSA-400337)
0.527
2
UniProt:P42336 PIK3CA
20
PIK3CA H1047L [cytosol]
(R-HSA-1500714)
PIK3CA H1047R [cytosol]
(R-HSA-1500716)
PIK3CA M1043I [cytosol]
(R-HSA-1500719)
PIK3CA M1043T [cytosol]
(R-HSA-2395934)
PIK3CA M1043V [cytosol]
(R-HSA-2395932)
PIK3CA H1047Y [cytosol]
(R-HSA-1500720)
PIK3CA E542K [cytosol]
(R-HSA-1500701)
PIK3CA Q546K [cytosol]
(R-HSA-1500705)
PIK3CA E545A [cytosol]
(R-HSA-2362355)
PIK3CA E545K [cytosol]
(R-HSA-1500706)
PIK3CA E545Q [cytosol]
(R-HSA-2362362)
PIK3CA Q546E [cytosol]
(R-HSA-2362383)
PIK3CA E545V [cytosol]
(R-HSA-2362365)
PIK3CA E542V [cytosol]
(R-HSA-2328074)
PIK3CA Q546L [cytosol]
(R-HSA-2362375)
PIK3CA E545G [cytosol]
(R-HSA-1500709)
PIK3CA Q546H [cytosol]
(R-HSA-2362374)
PIK3CA Q546R [cytosol]
(R-HSA-2362373)
PIK3CA Q546P [cytosol]
(R-HSA-1500695)
PIK3CA E542Q [cytosol]
(R-HSA-2328003)
0.527
2
UniProt:P0DTD8 NS7B
0.488
2
UniProt:P06239 LCK
4
p-Y394-LCK [plasma membrane]
(R-HSA-8857940)
p-Y505-LCK [plasma membrane]
(R-HSA-202159)
p-Y394-LCK [cytosol]
(R-HSA-202308)
LCK [cytosol]
(R-HSA-167609)
0.462
2
UniProt:P19174 PLCG1
6
p-Y-PLCG1 [cytosol]
(R-HSA-9029082)
p-4Y-PLCG1 [plasma membrane]
(R-HSA-167679)
PLCG1 [cytosol]
(R-HSA-202320)
PLCG1 [plasma membrane]
(R-HSA-167682)
p-Y771,Y783,Y1254-PLCG1 [cytosol]
(R-HSA-202357)
p-Y771,Y783-PLCG1 [plasma membrane]
(R-HSA-1169084)
0.462
3
UniProt:P43403 ZAP70
3
ZAP70 [cytosol]
(R-HSA-202397)
p-Y493-ZAP70 [cytosol]
(R-HSA-202368)
p-Y315,Y493-ZAP70 [cytosol]
(R-HSA-202252)
0.462
2
UniProt:P43405 SYK
6
p-Y-SYK [cytosol]
(R-HSA-9705732)
p-Y-SYK [plasma membrane]
(R-HSA-429432)
SYK [plasma membrane]
(R-HSA-139844)
p-6Y-SYK [cytosol]
(R-HSA-1861712)
p-Y348-SYK [cytosol]
(R-HSA-437953)
SYK [cytosol]
(R-HSA-58268)
0.462
3
UniProt:Q9NP31 SH2D2A
1
SH2D2A [cytosol]
(R-HSA-4420125)
0.462
3
UniProt:P06241 FYN
6
p-S21,Y420-FYN [cytosol]
(R-HSA-5218745)
p-Y531-FYN [cytosol]
(R-HSA-391819)
MyrG2-PalmC3,6-FYN [plasma membrane]
(R-HSA-9606873)
p-Y420-FYN [cytosol]
(R-HSA-391821)
MyrG-p-Y420-FYN [plasma membrane]
(R-HSA-1810410)
FYN [cytosol]
(R-HSA-200917)
0.462
2
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