Reactome | DDB2 [nucleoplasm]

DDB2 [nucleoplasm]

Stable Identifier

R-HSA-53491

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

DDB2, DNA damage binding protein 2, DNA damage binding protein 2, Damage-specific DNA binding protein 2, DDB p48 subunit, DDBb, UV-damaged DNA-binding protein 2, UV-DDB 2

Locations in the PathwayBrowser

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DNA Repair (Homo sapiens)

- Nucleotide Excision Repair (Homo sapiens)
  - Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
    - DNA Damage Recognition in GG-NER (Homo sapiens)
      - PARP1 or PARP2 PARylates DDB2 and autoPARylates (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB:PARP1,PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Homo sapiens)
        
        UV-DDB [nucleoplasm] (Homo sapiens)
        
        DDB1:DDB2 [nucleoplasm] (Homo sapiens)
        
        DDB2 [nucleoplasm] (Homo sapiens)
      - PARP1 or PARP2 binds DDB2 at GG-NER site (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Homo sapiens)
        
        UV-DDB [nucleoplasm] (Homo sapiens)
        
        DDB1:DDB2 [nucleoplasm] (Homo sapiens)
        
        DDB2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB:PARP1,PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Homo sapiens)
        
        UV-DDB [nucleoplasm] (Homo sapiens)
        
        DDB1:DDB2 [nucleoplasm] (Homo sapiens)
        
        DDB2 [nucleoplasm] (Homo sapiens)
      - UV-DDB ubiquitinates XPC (Homo sapiens)
        
        UV-DDB [nucleoplasm] (Homo sapiens)
        
        DDB1:DDB2 [nucleoplasm] (Homo sapiens)
        
        DDB2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Homo sapiens)
        
        UV-DDB [nucleoplasm] (Homo sapiens)
        
        DDB1:DDB2 [nucleoplasm] (Homo sapiens)
        
        DDB2 [nucleoplasm] (Homo sapiens)
        
        XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Homo sapiens)
        
        UV-DDB [nucleoplasm] (Homo sapiens)
        
        DDB1:DDB2 [nucleoplasm] (Homo sapiens)
        
        DDB2 [nucleoplasm] (Homo sapiens)
      - XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Homo sapiens)
        
        UV-DDB:COP9 Signalosome [nucleoplasm] (Homo sapiens)
        
        UV-DDB [nucleoplasm] (Homo sapiens)
        
        DDB1:DDB2 [nucleoplasm] (Homo sapiens)
        
        DDB2 [nucleoplasm] (Homo sapiens)
        
        XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Homo sapiens)
        
        UV-DDB [nucleoplasm] (Homo sapiens)
        
        DDB1:DDB2 [nucleoplasm] (Homo sapiens)
        
        DDB2 [nucleoplasm] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of DNA Repair Genes (Homo sapiens)
        
        TP53 stimulates DDB2 expression (Homo sapiens)
        
        DDB2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q92466 DDB2

Gene Names

DDB2

Chain

chain:1-427

Reference Genes

BioGPS Gene:1643 DDB2

COSMIC (genes):DDB2 DDB2

CTD Gene:1643 DDB2

dbSNP Gene:1643 DDB2

ENSEMBL:ENSG00000134574 DDB2

HGNC:2718 DDB2

KEGG:hsa:1643 DDB2

Monarch:1643 DDB2

NCBI Gene:1643 DDB2

OMIM:600811 DDB2

UCSC:Q92466 DDB2

Reference Transcript

Other Identifiers

11717397_a_at

11750080_a_at

1243_at

1643

16724471

203409_PM_at

203409_at

3327739

3329650

3329651

3329652

3329653

3329654

3329655

3329656

3329658

3329659

3329663

3329664

3329665

3329666

3329667

3329668

3329669

3329670

3329671

3329672

3329673

3329674

3329675

3329676

3329677

3329678

3329679

3329680

3329681

3329682

3329683

3329684

7939738

A_14_P111520

A_23_P52610

A_33_P3383955

GE58979

GO:0000209

GO:0000785

GO:0003677

GO:0003684

GO:0003824

GO:0004842

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0006281

GO:0006289

GO:0006290

GO:0006974

GO:0009411

GO:0016567

GO:0016740

GO:0030054

GO:0031464

GO:0031465

GO:0032991

GO:0034644

GO:0044877

GO:0051865

GO:0070914

GO:0080008

GO:0090734

GO:0140096

HMNXSV003042721

ILMN_1660817

PH_hs_0034842

TC11000404.hg

U18300_at

g4557514_3p_at

Participates

as a component of

as a member of

DCAF protein [nucleoplasm] (Homo sapiens)

as an output of

TP53 stimulates DDB2 expression (Homo sapiens)

Other forms of this molecule

PAR-DDB2 [nucleoplasm]

PolyUb-DDB2 [nucleoplasm]

Inferred To

Ddb2 [nucleoplasm] (Mus musculus)

Ddb2 [nucleoplasm] (Rattus norvegicus)

DDB2 [nucleoplasm] (Bos taurus)

DDB2 [nucleoplasm] (Canis familiaris)

DDB2 [nucleoplasm] (Gallus gallus)

DDB2 [nucleoplasm] (Sus scrofa)

Ghost homologue of DDB2 [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of DDB2 [nucleoplasm] (Dictyostelium discoideum)

Ghost homologue of DDB2 [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of DDB2 [nucleoplasm] (Plasmodium falciparum)

Ghost homologue of DDB2 [nucleoplasm] (Schizosaccharomyces pombe)

ddb2 [nucleoplasm] (Danio rerio)

ddb2 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001386807.1, NP_001386803.1, NP_001386805.1, XP_047282443.1, XP_054223851.1, NP_001386804.1, NP_000098.1, NP_001287663.1

OpenTargets

ENSG00000134574

ENSEMBL

ENST00000378603, ENST00000378600, ENSP00000478411, ENST00000378601, ENST00000256996, ENSP00000367866, ENSP00000367864, ENSP00000367863, ENSP00000256996, ENST00000616278, ENSG00000134574

GeneCards

DDB2

HPA

ENSG00000134574-DDB2

PRO

Q92466

Pharos - Targets

Q92466

GlyGen

Q92466

Orphanet

DDB2

HMDB Protein

HMDBP10931

PDB

6R91, 6R92, 4E5Z, 6R90, 3I7L, 3EI4, 6R8Y, 4E54, 6R8Z

Interactors (33)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16531 DDB1	1	DDB1 [nucleoplasm] (R-HSA-53489)	0.967	23
UniProt:Q13619 CUL4A	2	CUL4A [nucleoplasm] (R-HSA-976006) G76-NEDD8-K705-CUL4A [nucleoplasm] (R-HSA-8952514)	0.899	13
UniProt:Q92905 COPS5	3	CSN5 [cytosol] (R-HSA-9929354) COPS5 [nucleoplasm] (R-HSA-5697019) COPS5 [cytosol] (R-HSA-416963)	0.877	11
UniProt:Q13620 CUL4B	2	CUL4B [nucleoplasm] (R-HSA-975973) G76-NEDD8-K859-CUL4B [nucleoplasm] (R-HSA-8952522)	0.837	13
UniProt:Q7L5N1 COPS6	2	COPS6 [nucleoplasm] (R-HSA-5697026) COPS6 [cytosol] (R-HSA-416961)	0.788	9
UniProt:Q9BT78 COPS4	2	COPS4 [nucleoplasm] (R-HSA-5697020) COPS4 [cytosol] (R-HSA-416965)	0.725	5
UniProt:Q9BW61 DDA1	1	DDA1 [nucleoplasm] (R-HSA-8863297)	0.725	4
UniProt:Q99832 CCT7	1	CCT7 [cytosol] (R-HSA-390451)	0.725	5
UniProt:P78371 CCT2	3	CCT2 [cytosol] (R-HSA-390464) CCT2 [azurophil granule lumen] (R-HSA-6799356) CCT2 [extracellular region] (R-HSA-6806220)	0.725	6
UniProt:Q9UBW8 COPS7A	2	COPS7A [nucleoplasm] (R-HSA-5697011) COPS7A [cytosol] (R-HSA-416964)	0.725	6
UniProt:P62877 RBX1	2	RBX1 [nucleoplasm] (R-HSA-1234142) RBX1 [cytosol] (R-HSA-180582)	0.643	3
UniProt:Q9UNS2 COPS3	2	COPS3 [nucleoplasm] (R-HSA-5697017) COPS3 [cytosol] (R-HSA-416973)	0.643	4
UniProt:P48643 CCT5	1	CCT5 [cytosol] (R-HSA-390447)	0.643	4
UniProt:Q9NQP4 PFDN4	1	PFDN4 [cytosol] (R-HSA-379542)	0.643	4
UniProt:Q9H9Q2 COPS7B	2	COPS7B [nucleoplasm] (R-HSA-5697023) COPS7B [cytosol] (R-HSA-416966)	0.643	4
UniProt:Q99627 COPS8	2	COPS8 [cytosol] (R-HSA-416962) COPS8 [nucleoplasm] (R-HSA-5697014)	0.643	4
UniProt:O60232 ZNRD2			0.643	4
UniProt:Q9UHV9 PFDN2	1	PFDN2 [cytosol] (R-HSA-379544)	0.643	4
UniProt:Q99471 PFDN5	1	PFDN5 [cytosol] (R-HSA-379548)	0.643	3
UniProt:Q01831-1 XPC			0.576	4
UniProt:Q3U1J4	1	Ddb1 [nucleoplasm] (R-MMU-53489)	0.564	2
UniProt:P40337-2 VHL			0.556	3
UniProt:Q01094 E2F1	2	E2F1 [nucleoplasm] (R-HSA-68639) p-E2F1 [nucleoplasm] (R-HSA-187911)	0.544	2
UniProt:Q9NYZ3 GTSE1	4	GTSE1 [cytosol] (R-HSA-8852264) p-S435-GTSE1 [cytosol] (R-HSA-8852316) p-S435-GTSE1 [nucleoplasm] (R-HSA-8852332) p-T513,T526-GTSE1 [cytosol] (R-HSA-8852308)	0.527	2
UniProt:P53673 CRBA4			0.527	3
UniProt:Q9UBZ4 APEX2			0.527	2
UniProt:Q13098 GPS1	2	GPS1 [nucleoplasm] (R-HSA-5697010) GPS1 [cytosol] (R-HSA-416972)	0.527	4
UniProt:P61201 COPS2	2	COPS2 [nucleoplasm] (R-HSA-5697012) COPS2 [cytosol] (R-HSA-416971)	0.527	3
UniProt:Q8NBX0 SCCPDH	2	SCCPDH [extracellular region] (R-HSA-8862997) SCCPDH [platelet alpha granule lumen] (R-HSA-8862982)	0.527	3
UniProt:Q08830 FGL1			0.527	2
UniProt:P49368 CCT3	1	CCT3 [cytosol] (R-HSA-390463)	0.527	2
UniProt:Q6B0B8 TIGD3			0.527	2
UniProt:Q9NWH7 SPAT6			0.499	2